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Thrombosis and Hemostasis in Cancer pp 159–178Cite as

Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms

Part of the Cancer Treatment and Research book series (CTAR,volume 179)

Abstract

The myeloproliferative neoplasms (MPNs) are clonal stem cell-derived diseases. This chapter focuses on the subcategory of Philadelphia (Ph) chromosome-negative classical MPNs, polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). These MPNs are associated with both microvascular and macrovascular thrombosis, which may occur in the venous and arterial circulation. Erythrocytosis, leukocytosis, and increased JAK2V617F allele burden are known to be risk factors. In this chapter, we review the thrombotic and hemostatic manifestations of the Philadelphia (Ph) chromosome-negative classical MPNs, including the clinical manifestations, the pathophysiology, as well as management.

Keywords

  • Myeloproliferative neoplasms
  • Polycythemia vera
  • Essential thrombocythemia
  • Myelofibrosis
  • Microvascular thrombosis
  • Macrovascular thrombosis
  • JAK2V617F

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Authors and Affiliations

  1. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Kamya Sankar

  2. Department of Medicine/Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Brady L. Stein

  3. Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA

    Brady L. Stein

  4. Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Raajit K. Rampal

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  1. Kamya Sankar
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  2. Brady L. Stein
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  3. Raajit K. Rampal
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Correspondence to Raajit K. Rampal .

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Editors and Affiliations

  1. Medicine/Hematology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Dr. Gerald Soff

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Sankar, K., Stein, B.L., Rampal, R.K. (2019). Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms. In: Soff, G. (eds) Thrombosis and Hemostasis in Cancer. Cancer Treatment and Research, vol 179. Springer, Cham. https://doi.org/10.1007/978-3-030-20315-3_11

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  • DOI: https://doi.org/10.1007/978-3-030-20315-3_11

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