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Roles of Interactions Between Cells and Extracellular Matrices for Cell Migration and Matrix Remodeling

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Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 23))

Abstract

Cells can sense mechanical properties of surrounding environments and also structurally remodel the environments. Interactions between cells and extracellular matrix (ECM) play a crucial role in diverse cellular behaviors, including migration, growth, and differentiation. Advances in experimental and computational methods enabled us to better understand the molecular bases and underlying mechanisms of the cell-ECM interactions. This chapter provides a comprehensive review regarding how cells sense and remodel ECMs and why such capabilities are of great importance for cell migration. First, the molecular structure, dynamics, and functions of focal adhesions (FAs) formed between cells and ECM are discussed, followed by a brief review about the significance of interactions between FAs and the actin cytoskeleton occurring in the intracellular space. Then, it is discussed how cells remodel surrounding ECMs mechanically and biochemically. Additionally, various experimental and computational methods designed for studying cell migration facilitated by cell-ECM interactions and ECM remodeling are summarized, and findings obtained using these methods are discussed.

Jing Li and Wonyeong Jung are equal contribution.

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Authors and Affiliations

  1. Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN, 47907, USA

    Jing Li, Wonyeong Jung & Taeyoon Kim

  2. Department of Mechanical Engineering, Stanford University, 440 Escondido Mall, Stanford, CA, 94305, USA

    Sungmin Nam & Ovijit Chaudhuri

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  1. Jing Li
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  2. Wonyeong Jung
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  3. Sungmin Nam
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  4. Ovijit Chaudhuri
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  5. Taeyoon Kim
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Correspondence to Taeyoon Kim .

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  1. Department of Mechanical Engineering, Department of Biomedical Engineering and Division of Materials Science & Engineering, Boston University, Boston, MA, USA

    Yanhang Zhang

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Li, J., Jung, W., Nam, S., Chaudhuri, O., Kim, T. (2020). Roles of Interactions Between Cells and Extracellular Matrices for Cell Migration and Matrix Remodeling. In: Zhang, Y. (eds) Multi-scale Extracellular Matrix Mechanics and Mechanobiology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 23. Springer, Cham. https://doi.org/10.1007/978-3-030-20182-1_8

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