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Direct Oral Anticoagulants

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Hemostasis and Thrombosis

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Abstract

This chapter reviews the new direct oral anticoagulants – thrombin and Xa inhibitors. The specific drugs are reviewed as well as the specific indications – prevention and treatment of deep venous thrombosis, stroke prevention in atrial fibrillation, and acute coronary syndrome. Finally, common issues such as monitoring and choosing the appropriate patient to use the drugs in are reviewed.

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Suggested Reading

  • Barnes GD, Kurtz B. Direct oral anticoagulants: unique properties and practical approaches to management. Heart. 2016;102(20):1620–6.

    Article  CAS  Google Scholar 

  • Barr D, Epps QJ. Direct oral anticoagulants: a review of common medication errors. J Thromb Thrombolysis. 2019;47(1):146–54.

    Article  Google Scholar 

  • López-López JA, Sterne JAC, Thom HHZ, Higgins JPT, Hingorani AD, Okoli GN, Davies PA, Bodalia PN, Bryden PA, Welton NJ, Hollingworth W, Caldwell DM, Savović J, Dias S, Salisbury C, Eaton D, Stephens-Boal A, Sofat R. Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis. BMJ. 2017;359:j5058.

    Article  Google Scholar 

  • Samuelson BT, Cuker A, Siegal DM, Crowther M, Garcia DA. Laboratory assessment of the anticoagulant activity of direct oral anticoagulants: a systematic review. Chest. 2017;151(1):127–38.

    Article  Google Scholar 

  • van Es N, Coppens M, Schulman S, Middeldorp S, Büller HR. Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. Blood. 2014;124(12):1968–75.

    Article  Google Scholar 

  • Weber J, Olyaei A, Shatzel J. The efficacy and safety of direct oral anticoagulants in patients with chronic renal insufficiency: a review of the literature. Eur J Haematol. 2019;102(4):312–8.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Hematology/Medical Oncology, Department of Medicine, Pathology, and Pediatrics, Oregon Health & Sciences University, Portland, OR, USA

    Thomas G. DeLoughery

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  1. Thomas G. DeLoughery
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Correspondence to Thomas G. DeLoughery .

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Editors and Affiliations

  1. Division of Hematology/Medical Oncology, Oregon Health & Sciences University, Portland, OR, USA

    Thomas G. DeLoughery

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DeLoughery, T.G. (2019). Direct Oral Anticoagulants. In: DeLoughery, T. (eds) Hemostasis and Thrombosis. Springer, Cham. https://doi.org/10.1007/978-3-030-19330-0_24

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  • DOI: https://doi.org/10.1007/978-3-030-19330-0_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-19329-4

  • Online ISBN: 978-3-030-19330-0

  • eBook Packages: MedicineMedicine (R0)

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