Abstract
The oncologic care of the transgender patient is an area of increasing interest as this patient cohort continues to grow. Caring for these patients may be challenging due to limited literature on this topic and a lack of standard screening recommendations. It is critical that providers have a thorough knowledge of the transgender patients’ surgical and medical history related to the affirmation process to guide their care. The following chapter describes the known oncologic concerns in these patients based on the limited available literature.
Keywords
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Kiran T, Davie S, Singh D, Hranilovic S, Pinto AD, Abramovich A, et al. Cancer screening rates among transgender adults: Cross-sectional analysis of primary care data. Can Fam Physician. 2019;65(1):e30–e7.
Joint R, Chen ZE, Cameron S. Breast and reproductive cancers in the transgender population: a systematic review. BJOG. 2018;125(12):1505–12.
Deutsch M. Guidelines for the primary and gender-affirming care of transgender and gender nonbinary people. 2nd ed: University of California San Francisco, Center of Excellence for Transgender Health, Department of Family and Community Medicine; 2016.
Ceres M, Quinn GP, Loscalzo M, Rice D. Cancer screening considerations and cancer screening uptake for lesbian, gay, bisexual, and transgender persons. Semin Oncol Nurs. 2018;34(1):37–51.
Feldman J, Deutsch M. Primary care of transgender individuals UpToDate2019 [updated October 2018; cited 2018].
James SE, Herman JL, Rankin S, Keisling M, Mottet L, Anafi M. The report of the 2015 U.S. transgender survey. National Center for Transgender Equality: Washinton, DC; 2016.
Grant JM, Mottet LA, Tanis J, Herman JL, Harrison J, Keisling M. National transgender discrimination survey report on health and health care. Washington, DC: National Center for Transgender Equality and the National Gay and Lesbian Task Force; 2010.
Gatos KC. A literature review of cervical cancer screening in transgender men. Nurs Womens Health. 2018;22(1):52–62.
Unger CA. Care of the transgender patient: a survey of gynecologists' current knowledge and practice. J Womens Health (Larchmt). 2015;24(2):114–8.
Rebbeck TR. Prostate cancer genetics: variation by race, ethnicity, and geography. Semin Radiat Oncol. 2017;27(1):3–10.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.
Grady D, Gebretsadik T, Kerlikowske K, Ernster V, Petitti D. Hormone replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynecol. 1995;85(2):304–13.
Smith RA, Andrews KS, Brooks D, Fedewa SA, Manassaram-Baptiste D, Saslow D, et al. Cancer screening in the United States, 2019: a review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 2019;69(3):184–210.
Kent MA, Winoker JS, Grotas AB. Effects of feminizing hormones on sperm production and malignant changes: microscopic examination of post orchiectomy specimens in transwomen. Urology. 2018;121:93–6.
Bizic M, Kojovic V, Duisin D, Stanojevic D, Vujovic S, Milosevic A, et al. An overview of neovaginal reconstruction options in male to female transsexuals. Sci World J. 2014;2014:638919.
Yamada K, Shida D, Kato T, Yoshida H, Yoshinaga S, Kanemitsu Y. Adenocarcinoma arising in sigmoid colon neovagina 53 years after construction. World J Surg Oncol. 2018;16(1):88.
Webster T, Appelbaum H, Weinstein TA, Rosen N, Mitchell I, Levine JJ. Simultaneous development of ulcerative colitis in the colon and sigmoid neovagina. J Pediatr Surg. 2013;48(3):669–72.
McEvenue G, Xu FZ, Cai R, McLean H. Female-to-male gender affirming top surgery: a single surgeon’s 15-year retrospective review and treatment algorithm. Aesthet Surg J. 2017;38(1):49–57.
Deutsch MB, Radix A, Wesp L. Breast Cancer screening, management, and a review of case study literature in transgender populations. Semin Reprod Med. 2017;35(5):434–41.
Gooren L, Morgentaler A. Prostate cancer incidence in orchidectomised male-to-female transsexual persons treated with oestrogens. Andrologia. 2014;46(10):1156–60.
Markland C. Transexual surgery. Obstet Gynecol Annu. 1975;4:309–30.
Thurston AV. Carcinoma of the prostate in a transsexual. Br J Urol. 1994;73(2):217.
van Haarst EP, Newling DW, Gooren LJ, Asscheman H, Prenger DM. Metastatic prostatic carcinoma in a male-to-female transsexual. Br J Urol. 1998;81(5):776.
Miksad RA, Bubley G, Church P, Sanda M, Rofsky N, Kaplan I, et al. Prostate cancer in a transgender woman 41 years after initiation of feminization. JAMA. 2006;296(19):2316–7.
Dorff TB, Shazer RL, Nepomuceno EM, Tucker SJ. Successful treatment of metastatic androgen-independent prostate carcinoma in a transsexual patient. Clin Genitourin Cancer. 2007;5(5):344–6.
Turo R, Jallad S, Prescott S, Cross WR. Metastatic prostate cancer in transsexual diagnosed after three decades of estrogen therapy. Can Urol Assoc J. 2013;7(7–8):E544–6.
Ellent E, Matrana MR. Metastatic prostate cancer 35 years after sex reassignment surgery. Clin Genitourin Cancer. 2016;14(2):e207–9.
Sharif A, Malhotra NR, Acosta AM, Kajdacsy-Balla AA, Bosland M, Guzman G, et al. The development of prostate adenocarcinoma in a transgender male to female patient: could estrogen therapy have played a role? Prostate. 2017;77(8):824–8.
Deebel NA, Morin JP, Autorino R, Vince R, Grob B, Hampton LJ. Prostate Cancer in transgender women: incidence, etiopathogenesis, and management challenges. Urology. 2017;110:166–71.
Morgentaler A, Rhoden EL. Prevalence of prostate cancer among hypogonadal men with prostate-specific antigen levels of 4.0 ng/mL or less. Urology. 2006;68(6):1263–7.
Hoffman MA, DeWolf WC, Morgentaler A. Is low serum free testosterone a marker for high grade prostate cancer? J Urol. 2000;163(3):824–7.
Wolf-Gould CS, Wolf-Gould CH. A transgender woman with testicular cancer: a new twist on an old problem. LGBT Health. 2016;3(1):90–5.
Gooren LJ, van Trotsenburg MA, Giltay EJ, van Diest PJ. Breast cancer development in transsexual subjects receiving cross-sex hormone treatment. J Sex Med. 2013;10(12):3129–34.
Brown GR, Jones KT. Incidence of breast cancer in a cohort of 5,135 transgender veterans. Breast Cancer Res Treat. 2015;149(1):191–8.
Harder Y, Erni D, Banic A. Squamous cell carcinoma of the penile skin in a neovagina 20 years after male-to-female reassignment. Br J Plast Surg. 2002;55(5):449–51.
Fernandes HM, Manolitsas TP, Jobling TW. Carcinoma of the neovagina after male-to-female reassignment. J Low Genit Tract Dis. 2014;18(2):E43–5.
Lawrence A. Vaginal neoplasia in a male-to-female transsexual: case report, review of the literature, and recommendations for cytological screening. Int J Transgender. 2001;5(1).
Grosse A, Grosse C, Lenggenhager D, Bode B, Camenisch U, Bode P. Cytology of the neovagina in transgender women and individuals with congenital or acquired absence of a natural vagina. Cytopathology. 2017;28(3):184–91.
Braun H, Nash R, Tangpricha V, Brockman J, Ward K, Goodman M. Cancer in transgender people: evidence and methodological considerations. Epidemiol Rev. 2017;39(1):93–107.
American College of Obstetricians and Gynecologists. Committee opinion: health care for transgender individuals. Obstet Gynecol. 2011;118(6):1454–8.
Peitzmeier SM, Khullar K, Reisner SL, Potter J. Pap test use is lower among female-to-male patients than non-transgender women. Am J Prev Med. 2014;47(6):808–12.
Peitzmeier SM, Reisner SL, Harigopal P, Potter J. Female-to-male patients have high prevalence of unsatisfactory Paps compared to non-transgender females: implications for cervical cancer screening. J Gen Intern Med. 2014;29(5):778–84.
Schenck TL, Holzbach T, Zantl N, Schuhmacher C, Vogel M, Seidl S, et al. Vaginal carcinoma in a female-to-male transsexual. J Sex Med. 2010;7(8):2899–902.
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Scott, K., Bratslavsky, G., Ferry, E. (2021). Care of Transgender Patients: Oncological Concerns. In: Nikolavsky, D., Blakely, S.A. (eds) Urological Care for the Transgender Patient. Springer, Cham. https://doi.org/10.1007/978-3-030-18533-6_14
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