Abstract
Approximately 15% of children with peripheral neuroblastic tumors (PNTs) present with spinal canal involvement (SCI) by the tumor, and half of them develop important related symptoms. Symptomatic SCI requires prompt treatment: chemotherapy, neurosurgical intervention and radiation therapy may all be effective, but there is no consent on which should be given first in the different clinical presentations. The literature regarding PNT with SCI does not provide convincing guidelines, thus encouraging the establishment of a specific International Registry to provide data that could lead to the definition of a suitable therapeutic and follow-up algorithm.
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Abbreviations
- MRI:
-
Magnetic resonance imaging
- NB:
-
Neuroblastoma
- PNT:
-
Peripheral neuroblastic tumor
- SCI:
-
Spinal canal invasion
- SDI:
-
Symptom-diagnosis interval
- SIOPEN:
-
International Society of Paediatric Oncology Europe Neuroblastoma
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Ash, S., Sorrentino, S., Kraal, K., De Bernardi, B. (2020). Spinal Canal Involvement in Peripheral Neuroblastic Tumors. In: Sarnacki, S., Pio, L. (eds) Neuroblastoma. Springer, Cham. https://doi.org/10.1007/978-3-030-18396-7_9
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