Skip to main content
SpringerLink
Log in

Spinal Canal Involvement in Peripheral Neuroblastic Tumors

  • Chapter
  • First Online:
Book cover Neuroblastoma

Abstract

Approximately 15% of children with peripheral neuroblastic tumors (PNTs) present with spinal canal involvement (SCI) by the tumor, and half of them develop important related symptoms. Symptomatic SCI requires prompt treatment: chemotherapy, neurosurgical intervention and radiation therapy may all be effective, but there is no consent on which should be given first in the different clinical presentations. The literature regarding PNT with SCI does not provide convincing guidelines, thus encouraging the establishment of a specific International Registry to provide data that could lead to the definition of a suitable therapeutic and follow-up algorithm.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

MRI:

Magnetic resonance imaging

NB:

Neuroblastoma

PNT:

Peripheral neuroblastic tumor

SCI:

Spinal canal invasion

SDI:

Symptom-diagnosis interval

SIOPEN:

International Society of Paediatric Oncology Europe Neuroblastoma

References

  1. Luksch R, Castellani MR, Collini P, et al. Neuroblastoma (Peripheral neuroblastic tumors). Crit Rev Oncol Hematol. 2016;107:106–81.

    Article  Google Scholar 

  2. Punt J, Pritchard J, Pincott JR, Till K. Neuroblastoma: a review of 21 cases presenting with spinal cord compression. Cancer. 1980;45:3095–101.

    Article  CAS  Google Scholar 

  3. Hayes FA, Thompson EI, Hvizdala E, O’Connor D, Green AA. Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor. J Pediatr. 1984;104:221–4.

    Article  CAS  Google Scholar 

  4. Plantaz D, Rubie H, Michon J, et al. The treatment of neuroblastoma with intraspinal extension with chemotherapy followed by surgical removal of residual disease: A prospective study of 42 patients—Results of the NBL 90 study of the French Society of Pediatric Oncology. Cancer. 1996;78:311–319.

    Article  CAS  Google Scholar 

  5. De Bernardi B, Pianca C, Pistamiglio P, et al. Neuroblastoma with symptomatic spinal cord compression at diagnosis: treatment and results with 76 cases. J Clin Oncol. 2001;19:183–90.

    Article  Google Scholar 

  6. Katzenstein HM, Kent PM, London WB, Cohn SL. Treatment and outcome of 83 children with intraspinal neuroblastoma: the Pediatric Oncology Group experience. J Clin Oncol. 2001;19:1047–55.

    Article  CAS  Google Scholar 

  7. Hoover M, Bowman LC, Crawford SE, et al. Long-term outcome of patients with intraspinal neuroblastoma. Med Pediatr Oncol. 1999;32:353–9.

    Article  CAS  Google Scholar 

  8. Angelini P, Plantaz D, De Bernardi B, et al. Late sequelae of symptomatic epidural compression in children with localized neuroblastoma. Pediatr Blood Cancer. 2011;57:473–80.

    Article  Google Scholar 

  9. Simon T, Niemann CA, Hero B, et al. Short- and long-term outcome of patients with symptoms of spinal cord compression by neuroblastoma. Dev Med Child Neurol. 2012;54:347–52.

    Article  Google Scholar 

  10. Kraal K, Blom T, Tytgat L, et al. Neuroblastoma with intraspinal extension: health problems in long-term survivors. Pediatr Blood Cancer. 2016;63:990–6.

    Article  Google Scholar 

  11. De Bernardi B, Balwierz W, Bejent J, et al. Epidural compression in neuroblastoma: diagnostic and therapeutic aspects. Cancer Lett. 2005;228:283–99.

    Article  Google Scholar 

  12. Sandberg DI, Bilsky MH, Kushner BH, et al. Treatment of spinal involvement in neuroblastoma patients. Pediatr Neurosurg. 2003;39:291–8.

    Article  Google Scholar 

  13. Yiin JJ, Chang CS, Jan YJ, Wang YC. Treatment of neuroblastoma with intraspinal extensions. J Clin Neurosci. 2003;10:579–83.

    Article  Google Scholar 

  14. De Bernardi B, Quaglietta L, Haupt R, et al. Neuroblastoma with symptomatic epidural compression in the infant: the AIEOP experience. Pediatr Blood Cancer. 2014;61:1369–75.

    Article  Google Scholar 

  15. Fawzy M, El-Beltagy M, Shafei ME, et al. Intraspinal neuroblastoma: treatment options and neurological outcome of spinal cord compression. Oncol Lett. 2015;9:907–11.

    Article  Google Scholar 

  16. Trahair T, Sorrentino S, Russell SJ, et al. Spinal canal involvement in neuroblastoma. J Pediatr. 2017;188:294–8.

    Article  Google Scholar 

  17. Hoffer FA. Magnetic resonance imaging of abdominal masses in the pediatric patient. Semin Ultrasound CT MR. 2005;26:212–23.

    Article  Google Scholar 

  18. Yoshioka K, Tanaka R, Takagi H, et al. Ultra-high-resolution CT angiography of the artery of Adamkiewicz: a feasibility study. Neuroradiology. 2018;60:109–15.

    Article  Google Scholar 

  19. Boglino C, Martins AG, Ciprandi G, Sousinha M, Inserra A. Spinal cord vascular injuries following surgery and advanced thoracic neuroblastoma: an unusual catastrophic complication. Med Pediatr Oncol. 1999;35:349–52.

    Article  Google Scholar 

  20. Sainte-Rose C, Roux FX, Pierre-Kahn A, Renier D, Hirsch JF. Congenital intraspinal neuroblastomas. A propos of 7 cases treated surgically. Neurochirurgie. 1982;28:409–15.

    CAS  PubMed  Google Scholar 

  21. Sundaresan N, Sachdev VP, Holland JF, et al. Surgical treatment of spinal cord compression from epidural metastasis. J Clin Oncol. 1995;13:2330–5.

    Article  CAS  Google Scholar 

  22. Meyer NJ, Flatley TJ, Dunn DK. Superiorly based laminoplasty in children. J Spin Disor Techn. 2003;16:156–62.

    Article  Google Scholar 

  23. Ozerov SS, Samarin AE, Andreev ES, et al. Neurosurgical aspects of the treatment of neuroblastoma patients. Zh Vopr Neirokhir Im N N Burdenko. 2016;80:50–7.

    Article  CAS  Google Scholar 

  24. McGirt MJ, Chaichana KL, Atiba A, et al. Incidence of spinal deformity after resection of intramedullary spinal cord tumors in children who underwent laminectomy compared with laminoplasty. J Neurosurg Pediatr. 2008;1:57–62.

    Article  Google Scholar 

  25. Fischer JP, Tweddle DA. Neonatal neuroblastoma. Semin Fetal Neonatal Med. 2012;17:207–15.

    Article  Google Scholar 

  26. Asabe K, Handa N, Tamai Y, Kajiwara M, Hide T. A case of congenital intraspinal neuroblastoma. J Pediatr Surg. 1997;32:1371–6.

    Article  CAS  Google Scholar 

  27. Blackman SC, Evenson A, Voss SD, et al. Prenatal diagnosis and subsequent treatment of an intermediate-risk paraspinal neuroblastoma: case report and review of the literature. Fetal Diagn Ther. 2008;24:119–25.

    Article  Google Scholar 

  28. Walter KN, Kratz C, Uhl M, Niemeyer C. Chemotherapy as a therapeutic option for congenital neuroblastoma complicated by paraplegia. Klin Padiatr. 2008;220:175–7.

    Article  CAS  Google Scholar 

  29. Suffia C, Sorrentino S, Vetrella S, et al. Neuroblastoma presenting with symptoms of epidural compression at birth: a case report. Ital J Pediatr. 2016;42:52.

    Article  Google Scholar 

  30. Gigliotti AR, De Ioris MA, De Grandis E, et al. Congenital neuroblastoma with symptoms of epidural compression at birth. Pediatr Hematol Oncol. 2016;33:94–101.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Schneider Children’s Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikvah, Israel

    Shifra Ash

  2. Paediatric Oncology, IRCCS Istituto Giannina Gaslini, Genova, Italy

    Stefania Sorrentino & Bruno De Bernardi

  3. Emma Children’s Hospital/Academic Medical Centre (EKZ/AMC), Amsterdam, The Netherlands

    Kathelijne Kraal

  4. Princess Máxima Centre, Utrecht, The Netherlands

    Kathelijne Kraal

Authors
  1. Shifra Ash
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefania Sorrentino
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kathelijne Kraal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bruno De Bernardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bruno De Bernardi .

Editor information

Editors and Affiliations

  1. Department of Pediatric Surgery, Necker - Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, University of Paris, Paris, France

    Sabine Sarnacki

  2. Department of Pediatric Surgery, Necker - Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, University of Paris, Paris, France

    Luca Pio

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ash, S., Sorrentino, S., Kraal, K., De Bernardi, B. (2020). Spinal Canal Involvement in Peripheral Neuroblastic Tumors. In: Sarnacki, S., Pio, L. (eds) Neuroblastoma. Springer, Cham. https://doi.org/10.1007/978-3-030-18396-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-18396-7_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18395-0

  • Online ISBN: 978-3-030-18396-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation