Urticaria and Facial Angioedema

  • Elena Camelia Berghea

Practical Points

  • Chronic urticaria is less common in children than it is in adults [3]

  • The underlying cause of chronic urticaria in children do not appear to differ from those seen in adults [4]

  • The treatment algorithm recommended in children with chronic urticaria is the same like in adults

  • NSAIDs hypersensitivity is common in pediatric population and may precede the onset of chronic spontaneous urticaria by years [5]

  • Ibuprofen and paracetamol are among frequent causes of NSAID hypersensitivity in children

  • Oral drug provocation test is the gold standard for diagnosis of oral hypersensitivity reactions and allow identification of a safe alternative NSAID [6]


Drug-provocation test Chronic spontaneous urticaria Chronic inducible urticaria NSAIDs-exacerbated cutaneous disease 


  1. 1.
    Maurer M, Church MK, Goncalo M, Sussman G, Sanchez-Borges M. Management and treatment of chronic urticaria (CU). J Eur Acad Dermatol Venereol. 2015;29(Suppl 3):16–32.CrossRefGoogle Scholar
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    Zambonino MA, Torres MJ, Muñoz C, Requena G, Mayorga C, Posadas T, Urda A, Blanca M, Corzo JL. Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children. Pediatr Allergy Immunol. 2013;24(2):151–9.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elena Camelia Berghea
    • 1
    • 2
  1. 1.Emergency Clinical Hospital for Children M.S. CurieBucharestRomania
  2. 2.University of Medicine and Pharmacy Carol DavilaBucharestRomania

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