Recurrent Sepsis-Like Episodes

  • Purificacion Gonzalez-Delgado
  • Javier FernandezEmail author

Practical Points

  • Food-protein induced enterocolitis syndrome (FPIES) is a non-IgE mediated allergic disorder that typically occurs in infancy, characterized by profuse vomiting and diarrhea and even lethargy

  • Symptoms appear 1–4 h after food intake

  • Cow’s milk, soy and grains are the most common triggers for FPIES

  • Most patients recover at 2 or 3 years of age, but the development of specific IgE and solid-food FPIES report of a poor prognosis and prolonged course

  • Diagnosis is based on clinical history, exclusion of other causes and oral food challenge

  • Differential diagnoses include sepsis, acute gastrointestinal infection, surgical emergencies, metabolic and neurological disorders and other types of food allergy

  • Although FPIES is considered to be a result of T-cell-mediated disorder, the pathophysiology is not well known

  • The acute phase of severe FPIES must be treated with aggressive fluid resuscitation as a state of shock


Food-protein induced enterocolitis syndrome Specific IgE Oral food challenge Adrenaline 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Purificacion Gonzalez-Delgado
    • 1
  • Javier Fernandez
    • 1
    • 2
    Email author
  1. 1.Allergy SectionAlicante University General Hospital-ISABIALAlicanteSpain
  2. 2.Department of Clinical MedicineMiguel Hernandez UniversityAlicanteSpain

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