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Analysis of the Behavior of the Red Blood Cell Model in a Tapered Microchannel

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Bioinformatics and Biomedical Engineering (IWBBIO 2019)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 11466))

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Abstract

Red blood cells are flexible during their movement in microchannels, they adapt easily to their immediate environment and eventually return to their relaxed shape as soon as the environment exerts no forces on the cell. This behaviour is determined by elastic properties of red cell’s membrane which must be carefully taken in consideration when creating the computational model of red blood cell.

In our work we use previously developed model of red blood cell that employs five basic elastic moduli, each representing a different part of the overall elastic properties. The aim of this work is to assess the validity of such model. To this end we analyse behaviour of cells in tapered channels. By adapting to the flow conditions, cell begins to perform a certain type of repetitive motion. We focus on tank-treading and stretching. In this article we show that the model of red blood cell is capable of reconstruction these motions and we show quantitative and qualitative measures comparing the experimental and simulation data. We provide the analysis and description of these movements, and we study the effect of the cell’s initial position on the type of motion to be performed Query ID="Q3" Text="The affiliation “1” has been split into two different affiliations. And also check and confirm if the author and their affiliations are identified correctly." .

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Acknowledgements

This work was supported by the Slovak Research and Development Agency (contract number APVV-15-0751) and by the Ministry of Education, Science, Research and Sport of the Slovak Republic under the contract No. VEGA 1/0643/17.

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Correspondence to Mariana Ondrusova .

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Ondrusova, M., Cimrak, I. (2019). Analysis of the Behavior of the Red Blood Cell Model in a Tapered Microchannel. In: Rojas, I., Valenzuela, O., Rojas, F., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2019. Lecture Notes in Computer Science(), vol 11466. Springer, Cham. https://doi.org/10.1007/978-3-030-17935-9_37

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  • DOI: https://doi.org/10.1007/978-3-030-17935-9_37

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  • Print ISBN: 978-3-030-17934-2

  • Online ISBN: 978-3-030-17935-9

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