RENET: A Deep Learning Approach for Extracting Gene-Disease Associations from Literature

  • Ye Wu
  • Ruibang Luo
  • Henry C. M. Leung
  • Hing-Fung Ting
  • Tak-Wah LamEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11467)


Over one million new biomedical articles are published every year. Efficient and accurate text-mining tools are urgently needed to automatically extract knowledge from these articles to support research and genetic testing. In particular, the extraction of gene-disease associations is mostly studied. However, existing text-mining tools for extracting gene-disease associations have limited capacity, as each sentence is considered separately. Our experiments show that the best existing tools, such as BeFree and DTMiner, achieve a precision of 48% and recall rate of 78% at most. In this study, we designed and implemented a deep learning approach, named RENET, which considers the correlation between the sentences in an article to extract gene-disease associations. Our method has significantly improved the precision and recall rate to 85.2% and 81.8%, respectively. The source code of RENET is available at


Literature mining Relation Extraction Gene-disease association Deep learning 



This work was supported by Hong Kong ITF Grant ITS/331/17FP and General Research Fund No. 27204518.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ye Wu
    • 1
  • Ruibang Luo
    • 1
  • Henry C. M. Leung
    • 1
  • Hing-Fung Ting
    • 1
  • Tak-Wah Lam
    • 1
    Email author
  1. 1.Department of Computer ScienceThe University of Hong KongPokfulamHong Kong

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