Exercise (Prong-5)

  • Nicholas L. DePace
  • Joseph Colombo


“Exercise” covers a range of activities. However, the essential component is an “active lifestyle.” “Exercise” is not a bad word! It does not have to be drudgery. Exercise should reflect the lifestyles of people before automobiles, elevators, television remotes, and cell phones. It can be a single (preferably daily) acute bout of physical exertion or muscular activity that expends energy above one’s basal or resting level. Exercise can also be a daylong habit of activity, included but not limited to household chores, taking the stairs, shopping, gardening, walking, and playing with children. The physiologic and psychologic benefits of exercise are numerous.

The lack of exercise may place a patient on an accelerated track to autonomic neuropathy, accelerating the aging effect, keeping moving, and helping to keep joints, muscles, and nerves healthy. The Rostral Ventrolateral Medulla (RVLM) is a brain stem nucleus that receives a wide variety of inputs, including cardiovascular and exercise-related inputs from both central and peripheral sources, regulating sympathetic control over baroreceptor reflex and thereby blood pressure and under abnormal conditions, hypertension. Directly and indirectly, through the nervous system, exercise affects sleep, cognition, and memory; immune function; cardiovascular and endothelial function; GI function; endocrine and exocrine function; in fact, all systems of the body are positively impacted by appropriate levels of exercise. Exercise may be the most powerful antioxidant available. Further, it helps to elevate mood and relieve depression and, at the same time, relieve stress and potentially anxiety. Always consult your physician before starting an exercise regimen.


Active lifestyle Antioxidant Anxiety Blood pressure Depression Endothelial function Exercise Immune function Nervous system Rostral ventrolateral medulla 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nicholas L. DePace
    • 1
  • Joseph Colombo
    • 2
  1. 1.Franklin Cardiovascular Associates, PA and Autonomic Dysfunction and POTS CenterSewellUSA
  2. 2.TMCAMS, Inc.Franklin Cardiovascular Associates, PA and Autonomic Dysfunction and POTS CenterRichboroUSA

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