Abstract
Human bioastronautic programs have grown during the last 50 years. Medical and physiological findings from these missions have demonstrated that spaceflight impacts almost all physiological systems, including bone demineralization and reduced immunological competence. These adaptive responses can affect crew health and performance. Indeed, about half of the astronauts encountered immune dysregulations during space travels. Developing efficient countermeasures to preserve the astronaut’s immune system is therefore a prerequisite before undertaking future long-duration space missions. In this chapter, we present promising pharmacological countermeasures to mitigate that risk.
Keywords
- Immunosuppression
- Countermeasures
- Antioxidants
- Nucleotides
- AHCC
- DHEA
- Osteoporosis treatment
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Acknowledgments
JPF team was supported by CNES and the “Impact Biomolecules” project of the “Lorraine Université d’Excellence” (Investissements d’avenir—ANR 15-004), AS team by Amino Up Chemical, NASA, NuVue therapeutics and National Science Foundation, BC team by NASA and AC team by the DLR on behalf of the Federal Ministry of Economics and Technology (BMWi 50WB0719 and 50WB0919, 50WB1319) and the European Space Agency (ESA’s ELIPS 3 and 4 programs, and E3P).
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Le, T.T., Ropars, A., Sundaresan, A., Crucian, B., Choukér, A., Frippiat, JP. (2020). Pharmacological Countermeasures to Spaceflight-Induced Alterations of the Immune System. In: Choukèr, A. (eds) Stress Challenges and Immunity in Space. Springer, Cham. https://doi.org/10.1007/978-3-030-16996-1_35
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