Abstract
Previous chapters have provided some insight into the regulation of immune responses under spaceflight conditions which correspond to a unique combination of psychosocial and physical stressors. This multitude of factors affect almost all components of the immune system, potentially leading to compromised host defense against infections, and could consequently have an immediate impact on mission performance. This chapter introduces some strategies that are potentially helpful to mitigate the risk of immune dysfunction under conditions of long-duration spaceflight. Indeed, in a foreseeable time frame, man may voyage and explore the surfaces of solid bodies whose surface conditions are not too hostile for humans such as those of the Moon, Mars, phobos, and deimos (the two satellites of Mars).
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Acknowledgments
The authors wish to thank all participants of the 2017 meeting of the European Space Agency’s “Topical Team Stress Challenges and Immunity in Space.” This international meeting was funded by the European Space Agency and focused on countermeasures for immune dysregulation during space missions. The authors highly appreciate also all the discussions and inputs that cannot be reflected or attributed to each meeting participant in this introduction but are reflected due to given limitations. The authors also wish to acknowledge support provided by the NASA Human Research Program, Human Health and Countermeasures Element to BC. SP is supported by the program of fundamental research (theme 65.1) of the Institute for Biomedical Problems (IBMP), JPF and his team are supported by CNES (DAR 4800000894 and DAR 4800000950), AC and MH are funded under the German National Space Program (DLR) on behalf of the German Ministry of Economics and Energy (for AC BMWi 50WB1622).
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Frippiat, JP., Ponomarev, S.A., Heer, M., Crucian, B., Choukér, A. (2020). Preventive and Therapeutic Strategies to Counter Immune System Dysfunctioning During Spaceflight. In: Choukèr, A. (eds) Stress Challenges and Immunity in Space. Springer, Cham. https://doi.org/10.1007/978-3-030-16996-1_30
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DOI: https://doi.org/10.1007/978-3-030-16996-1_30
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