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Considerations for Development and Application of Health Monitoring Tools in Space

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Stress Challenges and Immunity in Space

Abstract

Health maintenance and disease prevention in astronauts are of high priority during space missions. To achieve this aim, basic science of molecular biology has to be joined with modern noninvasive tools allowing high-fidelity research on diagnosing and monitoring of the astronauts’ health status. Experts from biology, medicine, and engineering should merge their expertise to enable additive effects for development and improvement of stress and immune-monitoring tools under extreme environmental conditions. This will hereby ensure not only the success of space missions, especially when leaving the Earth orbit in the future, but also will provide important impetus for many other applications on Earth as well.

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References

  • Andaloussi SE, Mager I, Breakefield XO, Wood MJ (2013) Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 12:347–357

    Article  Google Scholar 

  • Antoniou M, Jorgensen AL, Kolamunnage-Dona R (2016) Biomarker-guided adaptive trial designs in phase II and phase III: a methodological review. PLoS One 11(2):e0149803

    Article  Google Scholar 

  • Ballantyne C (2007) Fact or fiction? Stress causes gray hair. Sci Am. http://www.scientificamerican.com/article.cfm?id=fact-or-fiction-stress-causes-gray-hair

  • Baumgartner C, Lewis GD, Netzer M, Pfeifer B, Gerszten RE (2010) A new data mining approach for profiling and categorizing kinetic patterns of metabolic biomarkers after myocardial injury. Bioinformatics 26(14):1745–1751

    Article  CAS  Google Scholar 

  • Brassard D, Clime L, Geissler M, Veres T (2015) Combining active pneumatic pumping and centrifugal forces : a new paradigm for the integration of bioanalytical assays. Proceedings of the 19th international conference on miniturized systems for chemistry and life sciences, MicroTAS, p 191

    Google Scholar 

  • Brassard D, Clime L, Mounier M, Veres T (2016) Programmable aliquots in passive microfluidic devices using a centrifugal platform with active pneumatic pumping. Proceedings of 20th international conference on miniaturized systems for chemistry and life sciences, MicroTAS, p 857

    Google Scholar 

  • Brassard D et al (2017) Advanced centrifugal microfluidic platform for the automation of clinical assays. American Association for Clinical Chemistry (AACC) annual meeting

    Google Scholar 

  • Brassard D et al (2018a) High-yield automated extraction of nucleic acids from whole blood using a centrifugal microfluidic platform with active pneumatic pumping. Proceedings of the 22th international conference on miniaturized systems for chemistry and life sciences, MicroTAS, p 141

    Google Scholar 

  • Brassard D et al (2018b) Microfluidic-based platform for universal sample preparation and biological assays automation for life-sciences research and remote medical applications. Deep space gateway science workshop (2018) LPI Contrib. No. 2063

    Google Scholar 

  • Clime L, Brassard D, Veres T (2014) Centrifugal microfluidic chip platform. PCT/IB2015/051591-US20170036208A1

    Google Scholar 

  • Clime L, Brassard D, Geissler M, Veres T (2015) Active pneumatic control of centrifugal microfluidic flows for lab-on-a-chip applications. Lab Chip 15:2400–2411

    Article  CAS  Google Scholar 

  • Cui F, Rhee M, Singh A, Tripathi A (2015) Microfluidic sample preparation for medical diagnostics. Annu Rev Biomed Eng 17:11.1–11.20

    Article  Google Scholar 

  • Erickson D, O'Dell L, Jiang L, Oncescu V, Gumus A, Lee S, Mancuso M, Mehta S (2014) Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics. Lab Chip 14:3159–3167

    Article  CAS  Google Scholar 

  • Gidlow CJ, Randall J, Gillman J, Silk S, Jones MV (2016) Hair cortisol and self-reported stress in healthy, working adults. Psychoneuroendocrinology 63:163–169

    Article  CAS  Google Scholar 

  • Hurst VW, Peterson S, Garcia K, Ebert D, Ham D, Amponsah D, Dulchavsky S (2015) Concept of operations evaluation for using remote-guidance ultrasound for exploration spaceflight. Aerosp Med Hum Perform 86(12):1034–1038

    Article  Google Scholar 

  • Kirkpatrick AW, Blaivas M, Sargsyan AE, McBeth PB, Patel C, Xiao Z, Pian L, Panebianco N, Hamilton DR, Ball CG, Dulchavsky SA (2013) Enabling the mission through trans-atlantic remote mentored musculoskeletal ultrasound: case report of a portable hand-carried tele-ultrasound system for medical relief missions. Telemed J E Health 19(7):530–534

    Article  Google Scholar 

  • Kottnerus JA, van Weel C, Muris JWM (2002) Evaluation of diagnostic procedures. BMJ 324:477–480

    Article  Google Scholar 

  • Kraft NO, Lyons TJ, Binder H (2003) Intercultural crew issues in long-duration spaceflight. Aviat Space Environ Med 74:575–578

    PubMed  Google Scholar 

  • Manzey D (2004) Human missions to Mars: new psychological challenges and research issues. Acta Astronaut 55:781–790

    Article  Google Scholar 

  • Mielczarek WS, Obaje EA, Bachmann TT, Kersaudy-Kerhoas M (2016) Microfluidic blood plasma separation for medical diagnostics: is it worth it? Lab Chip 16:3441–3448

    Article  CAS  Google Scholar 

  • Muzet A, Werner S, Fuchs G, Roth T, Saoud JB, Viola AU, Schaffhauser JY, Luthringer R (2016) Assessing sleep architecture and continuity measures through the analysis of heart rate and wrist movement recordings in healthy subjects: comparison with results based on polysomnography. Sleep Med 21:47–56

    Article  Google Scholar 

  • Nagrath S, Sequist L, Maheswaran S, Bell D, Irimia D, Ulkus L, Smith M, Kwak E, Digumarthy S, Muzikansky A, Ryan P, Balis U, Tompkins R, Haber D, Toner M (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450:1235–1239

    Article  CAS  Google Scholar 

  • Nicogossian AE, Pober DF, Roy SA (2001) Evolution of telemedicine in the space program and earth applications. Telemed J E Health 7(1):1–15

    Article  CAS  Google Scholar 

  • Otto C, Hamilton DR, Levine BD, Hare C, Sargsyan AE, Altshuler P, Dulchavsky SA (2009) Into thin air: extreme ultrasound on Mt Everest. Wilderness Environ Med 20(3):283–289

    Article  Google Scholar 

  • Otto C, Comtois JM, Sargsyan A, Dulchavsky A, Rubinfeld I, Dulchavsky S (2010) The Martian chronicles: remotely guided diagnosis and treatment in the Arctic Circle. Surg Endosc 24(9):2170–2177

    Article  Google Scholar 

  • Patabadige DEW, Jia S, Sibbitts J, Sadeghi J, Sellens K, Culbertson CT (2016) Micro total analysis systems: Fundamental advances and applications. Anal Chem 88:320–338

    Article  CAS  Google Scholar 

  • Ratajczak MZ, Ratajczak J (2016) Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later. Clin Transl Med 5:7

    Article  Google Scholar 

  • Sackmann EK, Fulton AL, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507:181–189

    Article  CAS  Google Scholar 

  • Stalder T, Steudte-Schmiedgen S, Alexander N, Klucken T, Vater A, Wichmann S, Kirschbaum C, Miller R (2017) Stress-related and basic determinants of hair cortisol in humans: A meta-analysis. Psychoneuroendocrinology 77:261–274

    Article  CAS  Google Scholar 

  • Tan SJ, Yobas L, Lee GY, Ong CN, Lim CT (2009) Microdevice for the isolation and enumeration of cancer cells from blood. Biomed Microdevices 11:883–892

    Article  Google Scholar 

  • Tkach M, Thery C (2016) Communication by extracellular vesicles: where we are and where we need to go. Cell 164:1226–1232

    Article  CAS  Google Scholar 

  • Turner ME, Pratkanis AR (1998) Twenty-five years of groupthink theory and research: lessons from the evaluation of a theory. Organ Behav Hum Decis Process 73:105–115

    Article  CAS  Google Scholar 

  • Ushakov IB, Karpov AA, Kryuchkov BI, Poliakov AV, Usov VM (2015) Promising options for medical robotics application in support of crew life activities and mitigation of medical risks during space flight. Aviakosm Ekolog Med 49(6):76–78

    PubMed  Google Scholar 

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Correspondence to Ines Kaufmann .

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Kaufmann, I., Veres, T., Buchheim, JI., Choukér, A. (2020). Considerations for Development and Application of Health Monitoring Tools in Space. In: Choukèr, A. (eds) Stress Challenges and Immunity in Space. Springer, Cham. https://doi.org/10.1007/978-3-030-16996-1_21

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  • DOI: https://doi.org/10.1007/978-3-030-16996-1_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16995-4

  • Online ISBN: 978-3-030-16996-1

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