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Charged-Particle Proton Radiosurgery

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Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy

Abstract

Proton intracranial radiosurgery (SRS) and fractionated stereotactic (FSRT) treatments have a long history, dating back to the 1960s. Proton SRS/FSRT treatments have predominantly focused on benign intracranial conditions such as meningioma, arteriovenous malformation (AVM), pituitary adenoma, and vestibular schwannoma. Dosimetric comparisons between proton and photon SRS delivery have revealed superior normal tissue-sparing effect of protons, predominantly seen with large and irregularly shaped lesions, and most obvious in the low isodose regions. Clinical data demonstrate that proton SRS achieves control rates comparable to those achieved with photon techniques. These excellent outcomes are achieved with minimal acute and few late toxicities. These results therefore support the use of proton SRS/FSRT, especially in patients who will likely be long-term survivors.

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Author information

Authors and Affiliations

  1. Central Connecticut Radiation Oncology, PC, Department of Radiation Oncology, Middletown, CT, USA

    Arpit M. Chhabra

  2. Rush University Medical Center, Department of Radiation Oncology, Chicago, IL, USA

    Mudit Chowdhary

  3. Miami Cancer Institute—Baptist Health South Florida, Department of Radiation Oncology, Miami, FL, USA

    Minesh P. Mehta

Authors
  1. Arpit M. Chhabra
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  2. Mudit Chowdhary
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  3. Minesh P. Mehta
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Correspondence to Minesh P. Mehta .

Editor information

Editors and Affiliations

  1. Mayo Clinic, Radiation Oncology, Mayo Clinic School of Medicine Radiation Oncology, Jacksonville, FL, USA

    Daniel M. Trifiletti

  2. Department of Radiation Oncology, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA

    Samuel T. Chao

  3. Sunnybrook Odette Cancer Centre, Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada

    Arjun Sahgal

  4. University of Virginia, Departments of Neurological Surgery and Radiation Oncology, Charlottesville, VA, USA

    Jason P. Sheehan

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Chhabra, A.M., Chowdhary, M., Mehta, M.P. (2019). Charged-Particle Proton Radiosurgery. In: Trifiletti, D., Chao, S., Sahgal, A., Sheehan, J. (eds) Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-16924-4_9

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  • DOI: https://doi.org/10.1007/978-3-030-16924-4_9

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