Skip to main content

Ruta graveolens L. (Rutaceae)

(Syn.: R. hortensis Mill.)

  • Chapter
  • First Online:
Handbook of 200 Medicinal Plants

Abstract

Native to the Mediterranean region but distributed throughout the world and cultivated as medicinal and ornamental herb. The herb was held in high esteem by the Greeks and Romans. Aristotle mentioned that the weasel rubs itself against this plant before fighting with serpents. Hippocrates considered it resolvent and diuretic, while Pliny called it one of the best medicinal herbs. Rue has been called the “Herb of Grace ” because its bitterness makes it the symbol of repentance. Among the Muslims it is highly revered, for it was blessed by the grateful Prophet after it had cured him of an illness. In superstitious practices of the time, the plant was hung round the neck as a charm against vertigo and epilepsy; it was considered emblematic of good luck, and a protection against sorcery, an herb dear to women. Dioscorides described rue injurious to pregnant women, as it was regarded antaphrodisiac and to cause abortion in pregnant women. Arab physicians regarded it attenuant, vesicant and stimulant, and used it to increase mental powers, to act as a tonic and digestive, and to increase urinary and menstrual excretions. Old European physicians considered it antispasmodic, emmenagogue, and stimulant, and prescribed it in hysteria and flatulent colic. In Taiwan its decoction is used for cardioprotection, and to treat various rheumatological and skin diseases in Spain. Traditionally it is used by the Jordanian population for its diuretic, antispasmodic, sedative and analgesic effects, and externally as an antirheumatic, and was used in medieval Persian medicine as a male contraceptive. It has frequently been used with success to procure abortion, starting with pain in the back bearing down, and frequent micturition, followed by pains and abortion about ten days after starting administration of the herb. Roots yielded coumarin derivative, naphthoherniarin, furanoacridone and dihydrofuroacridone alkaloids. Aerial parts contain simple coumarins, furanocoumarins, dihydrofuranocoumarins, quinoline and quinolone alkaloids, phenolic compounds, glycosides, and ketones. Potential anticonception activity of powdered root, aerial parts and the aqueous extract of aerial parts was reported in rats. Reduced spermatogenesis in rats was also reported of ethanol extract after 20-days treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Tayyab M: Personal Communication.

References

  1. Adsersen A, Gauguin B, Gudiksen L, Jäger AK. Screening of plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity. J Ethnopharmacol. 2006;104:418–22.

    Article  Google Scholar 

  2. Águila L, Ruedlinger J, Mansilla K, et al. Relaxant effects of a hydroalcoholic extract of Ruta graveolens on isolated rat tracheal rings. Biol Res. 2015;48:28.

    Google Scholar 

  3. Al-Okbi SY, El-Sayed EM, Ammar NM, et al. Effect of Ruta graveolens L. and Euphorbia peplus L. anti-inflammatory extracts on nutritional status of rats and the safety of their use. Indian J Exp Biol. 2002;40:45–8.

    Google Scholar 

  4. Arias-Santiago SA, Fernández-Pugnaire MA, Almazán-Fernández FM, et al. Phytophotodermatitis due to Ruta graveolens prescribed for fibromyalgia. Rheumatology (Oxford). 2009;48:1401.

    Google Scholar 

  5. Atta AH, Alkofahi A. Antinociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol. 1998;60:117–24.

    Article  CAS  Google Scholar 

  6. Chen CC, Huang YL, Huang FI, et al. Water-soluble glycosides from Ruta graveolens. J Nat Prod. 2001;64:990–2.

    Article  CAS  Google Scholar 

  7. Chiu KW, Fung AY. The cardiovascular effects of green beans (Phaseolus aureus), common rue (Ruta graveolens), and kelp (Laminaria japonica) in rats. Gen Pharmacol. 1997;29:859–62.

    Article  CAS  Google Scholar 

  8. Ciganda C, Laborde A. Herbal infusions used for induced abortion. J Toxicol Clin Toxicol. 2003;41:235–9.

    Article  Google Scholar 

  9. Conway GA, Slocumb JC. Plants used as abortifacients and emmenagogues by Spanish New Mexicans. J Ethnopharmacology. 1979;1:241–61.

    Article  CAS  Google Scholar 

  10. De Feo V, De Simone F, Senatore F. Potential allelochemicals from the essential oil of Ruta graveolens. Phytochemistry. 2002;61:573–8.

    Article  Google Scholar 

  11. de Freitas TG, Augusto PM, Montanari T. Effect of Ruta graveolens L. on pregnant mice. Contraception. 2005;71:74–7.

    Google Scholar 

  12. Dubakiene R, Kupriene M. Scientific problems of photosensitivity. Medicina (Kaunas). 2006;42:619–24 (Review).

    Google Scholar 

  13. Eickhorst K, DeLeo V, Csaposs J. Rue the herb: Ruta graveolens—associated phytophototoxicity. Dermatitis. 2007;18:52–5.

    Article  CAS  Google Scholar 

  14. Fadlalla K, Watson A, Yehualaeshet T, et al. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res. 2011;31:233–41.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Freyer G, You B, Villet S, et al. Open-label uncontrolled pilot study to evaluate complementary therapy with Ruta graveolens 9c in patients with advanced cancer. Homeopathy. 2014;103:232–8.

    Article  Google Scholar 

  16. Gandhi M, Lal R, Sankaranarayanan A, Sharma PL. Postcoital antifertility action of Ruta graveolens in female rats and hamsters. J Ethnopharmacol. 1991;34:49–59.

    Article  CAS  Google Scholar 

  17. Gawkrodger DJ, Savin JA. Phytophotodermatitis due to common rue (Ruta graveolens). Contact Derm. 1983;9:224.

    Article  CAS  Google Scholar 

  18. Gentile MT, Russo R, Pastorino O, et al. Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via MEK-ERK1/2 pathway. Exp Cell Res. 2018;364:50–8.

    Article  CAS  Google Scholar 

  19. Ghosh S, Sikdar S, Mukherjee A, Khuda-Bukhsh AR. Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo. J Integr Med. 2015;13:34–44.

    Article  Google Scholar 

  20. Guarrera PM. Traditional antihelmintic, antiparasitic and repellent uses of plants in Central Italy. J Ethnopharmacol. 1999;68:183–92.

    Article  CAS  Google Scholar 

  21. Gutiérrez-Pajares JL, Zúñiga L, Pino J. Ruta graveolens aqueous extract retards mouse preimplantation embryo development. Reprod Toxicol. 2003;17:667–72.

    Article  Google Scholar 

  22. Hale AL, Meepagala KM, Oliva A, et al. Phytotoxins from the leaves of Ruta graveolens. J Agric Food Chem. 2004;52:3345–9.

    Article  CAS  Google Scholar 

  23. Harat ZN, Sadeghi MR, Sadeghipour HR, et al. Immobilization effect of Ruta graveolens L. on human sperm: a new hope for male contraception. J Ethnopharmacol. 2008;115:36–41.

    Google Scholar 

  24. Harat ZN, Lakpour N, Sadeghipoor HR, et al. Immobilising effect of Ruta graveolens L. on human spermatozoa: coumarin compounds are involved. Andrologia. 2015;47:1183–9.

    Google Scholar 

  25. Heskel NS, Amon RB, Storrs FJ, White CR Jr. Phytophotodermatitis due to Ruta graveolens. Contact Dermatitis. 1983;9:278–80.

    Article  CAS  Google Scholar 

  26. Kannan R, Babu UV. Identity and pharmacognosy of Ruta graveolens Linn. Anc Sci Life. 2012;32:16–9.

    Article  CAS  Google Scholar 

  27. Karp JC, Sanchez C, Guilbert P, et al. Treatment with Ruta graveolens 5CH and Rhus toxicodendron 9CH may reduce joint pain and stiffness linked to aromatase inhibitors in women with early breast cancer: results of a pilot observational study. Homeopathy. 2016;105:299–308.

    Article  Google Scholar 

  28. Khori V, Nayebpour M, Semnani S, et al. Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts. Potential role as an antiarrhythmic agent. Saudi Med J. 2008;29:357–63.

    Google Scholar 

  29. Khouri NA, El-Akawi Z. Antiandrogenic activity of Ruta graveolens L in male albino rats with emphasis on sexual and aggressive behavior. Neuro Endocrinol Lett. 2005;26:823–9.

    PubMed  Google Scholar 

  30. Kikalishvili BIu, Zurabishvili DZ, Turabelidze DG, Shanidze LA, Nikolaĭshvili MN. The fatty acid composition of Ruta graveolens seed oil and its byological activity. Georgian Med News. 2013;224:82–4 (Russian).

    Google Scholar 

  31. Kong YC, Lau CP, Wat KH, et al. Antifertility principle of Ruta graveolens. Planta Med. 1989;55:176–8.

    Article  CAS  Google Scholar 

  32. Lans C. Ethnomedicines used in Trinidad and Tobago for reproductive problems. J Ethnobiol Ethnomed. 2007;3:13.

    Google Scholar 

  33. Loonat F, Amabeoku GJ. Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats. Afr J Tradit Complement Altern Med. 2014;11:173–81.

    Google Scholar 

  34. Mancuso G, Borgonovo G, Scaglioni L, Bassoli A. Phytochemicals from Ruta graveolens activate TAS2R bitter taste receptors and TRP channels involved in gustation and nociception. Molecules. 2015;20:18907–22.

    Article  CAS  Google Scholar 

  35. Mascolo N, Autore G, Capasso F. Biological screening of Italian medicinal plants for anti-inflammatory activity. Phytother Res. 1987;1:28–31.

    Article  Google Scholar 

  36. Naghibi Harat Z, Lakpour N, Sadeghipoor HR, et al. Immobilising effect of Ruta graveolens L. on human spermatozoa: coumarin compounds are involved. Andrologia, 2015;47:1183–9.

    Google Scholar 

  37. Nieschulz O, Schneider G. Pharmacological findings on alkaloids from Ruta graveolens L. Naturwissenschaften. 1965;52:394–5 (German).

    Google Scholar 

  38. Novak I, Buzas G, Minker E, et al. Active constituents of Ruta graveolens. Pharmazie. 1965;20:738.

    CAS  PubMed  Google Scholar 

  39. Oliva A, Meepagala KM, Wedge DE, et al. Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. J Agric Food Chem. 2003;51:890–6.

    Google Scholar 

  40. Orlita A, Sidwa-Gorycka M, Paszkiewicz M, et al. Application of chitin and chitosan as elicitors of coumarins and fluoroquinolone alkaloids in Ruta graveolens L. (common rue). Biotechnol Appl Biochem. 2008;51:91–6.

    Google Scholar 

  41. Paulini H, Popp R, Schimmer O, et al. Isogravacridonchlorine: a potent and direct acting frameshift mutagen from the roots of Ruta graveolens. Planta Med. 1991;57:59–61.

    Article  CAS  Google Scholar 

  42. Paulini H, Waibel R, Kiefer J, Schimmer O. Gravacridondiol acetate, a new dihydrofuroacridone alkaloid from Ruta graveolens. Planta Med. 1991;57:82–3.

    Article  CAS  Google Scholar 

  43. Prakash AO, Saxena V, Shukla S, et al. Anti-implantation activity of some indigenous plants in rats. Acta Europaea Fertilitatis. 1985;16:441–8.

    CAS  PubMed  Google Scholar 

  44. Preethi KC, Kuttan G, Kuttan R. Antitumour activity of Ruta graveolens extract. Asian Pac J Cancer Prev. 2006;7:439–43.

    CAS  PubMed  Google Scholar 

  45. Ratheesh M, Shyni GL, Helen A. Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats. Inflammopharmacology. 2009;17:100–5.

    Google Scholar 

  46. Ratheesh M, Helen A. Oral administration of alkaloid fraction from Ruta graveolens inhibits oxidative stress and inflammation in hypercholesterolemic rabbits. Pharm Biol. 2013;51:1552–8.

    Article  CAS  Google Scholar 

  47. Ratheesh M, Shyni GL, Sindhu G, Helen A. Inhibitory effect of Ruta graveolens L. on oxidative damage, inflammation and aortic pathology in hypercholesteromic rats. Exp Toxicol Pathol. 2011;63:285–90.

    Google Scholar 

  48. Ratheesh M, Shyni GL, Sindhu G, Helen A. Protective effects of isolated polyphenolic and alkaloid fractions of Ruta graveolens L. on acute and chronic models of inflammation. Inflammation. 2010;33:18–24.

    Google Scholar 

  49. Ratheesh M, Sindhu G, Helen A. Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L. Inflamm Res. 2013;62:367–76.

    Article  CAS  Google Scholar 

  50. Rózsa Z, Mester I, Reisch J, Szendrei K. Naphthoherniarin: an unusual coumarin derivative from Ruta graveolens1. Planta Med. 1989;55:68–9.

    Article  Google Scholar 

  51. Saeidinia A, Keihanian F, Delavar SF, et al. Lack of antibacterial activity of Ruta graveolens extracts against Enterococcus fecalis. Pak J Pharm Sci. 2016;29(4 Suppl):1371–4.

    CAS  PubMed  Google Scholar 

  52. Sailani MR, Moeini H. Effect of Ruta graveolens and Cannabis sativa alcoholic extract on spermatogenesis in the adult Wistar male rats. Indian J Urol. 2007;23:257–60.

    Article  CAS  Google Scholar 

  53. Salib JY, El-Toumy SA, Hassan EM, et al. New quinoline alkaloid from Ruta graveolens aerial parts and evaluation of the antifertility activity. Nat Prod Res. 2014;28:1335–42.

    Article  CAS  Google Scholar 

  54. Schempp CM, Schöpf E, Simon JC. Bullous phototoxic contact dermatitis caused by Ruta graveolens L. (garden rue), Rutaceae. Case report and review of literature. Hautarzt 1999;50:432–34 (German).

    Google Scholar 

  55. Seak CJ, Lin CC. Ruta graveolens intoxication. Clin Toxicol (Phila). 2007;45:173–5.

    Google Scholar 

  56. Tarique M, Siddiqui HH, Khushtar M, Rahman MA. Protective effect of hydroalcoholic extract of Ruta graveolens Linn. leaves on indomethacin and pylorus ligation-induced gastric ulcer in rats. J Ayurveda Integr Med. 2016;7:38–43.

    Google Scholar 

  57. Thring TS, Weitz FM. Medicinal plant use in the Bredasdorp/Elim region of the Southern Overberg in the Western Cape Province of South Africa. J Ethnopharmacol. 2006;103:261–75.

    Article  CAS  Google Scholar 

  58. Ueng YF, Chen CC, Huang YL, et al. Effects of aqueous extract of Ruta graveolens and its ingredients on cytochrome P450, uridine diphosphate (UDP)-glucuronosyltransferase, and reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-quinone oxidoreductase in mice. J Food Drug Anal. 2015;23:516–28.

    Article  CAS  Google Scholar 

  59. Van Cauwenberge H, Franchimont P. Anti-inflammatory activity of Z 6000 (trihydroxyethylrutoside) in rats. Arch Int Pharmacodyn Ther. 1977;170:74.

    Google Scholar 

  60. Wehr K. Criminal abortion using ruta roots (Ruta graveolens L.). Beitr Gerichtl Med. 1974;32:126–31 (German, Eng. Abstr).

    Google Scholar 

  61. Zaidi SF, Muhammad JS, Shahryar S, et al. Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells. J Ethnopharmacol. 2012;141:403c10.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahid Akbar .

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Akbar, S. (2020). Ruta graveolens L. (Rutaceae). In: Handbook of 200 Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-16807-0_162

Download citation

Publish with us

Policies and ethics