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Occult Primary Breast Cancer with Axillary Metastases

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Breast Disease

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Abstract

Occult primary cancer is defined as the presence of metastatic cancer with an undetectable primary at the time of presentation. Occult breast cancer remains controversial. The low incidence of this cancer precludes prospective trials, and thus evidence-based conclusions must be based on retrospective data.

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References

  1. Ellerbroek N, Holmes F, Singletary E, Evans H, Oswald M, McNeese M. Treatment of patients with isolated axillary nodal metastases from an occult primary carcinoma consistent with breast origin. Cancer. 1990;66:1461–7.

    Article  CAS  PubMed  Google Scholar 

  2. Galimberti V, Bassani G, Monti S, Simsek S, Villa G, Renne G, Luini A. Clinical experience with axillary presentation breast cancer. Breast Cancer Res Treat. 2004;88:43–7.

    Article  PubMed  Google Scholar 

  3. Masinghe SP, Faluyi OO, Kerr GR, Kunkler IH. Breast radiotherapy for occult breast cancer with axillary nodal metastases-does it reduce the local recurrence rate and increase overall survival? Clin Oncol. 2011;23:95–100.

    Article  CAS  Google Scholar 

  4. Merson M, Andreola S, Galimberti V, Bufalino R, Marchini S, Veronesi U. Breast carcinoma presenting as axillary metastases without evidence of a primary tumor. Cancer. 1992;70(2):504–8.

    Article  CAS  PubMed  Google Scholar 

  5. Montagna E, Bagnardi V, Rotmensz N, Viale G, Cancello G, Mazza M, et al. Immunohistochemically defined subtypes and outcome in Occult Breast Carcinoma with axillary presentation. Breast Cancer Res Treat. 2011;129:867–75.

    Article  CAS  PubMed  Google Scholar 

  6. Surveillance Epidemiology and End Results (SEER) Database. Available at http://seer.cancer.gov/statistics/.

  7. Siegel R, Naishadham D, Jemal A. Cancer statistics. Cancer J Clin. 2012;62:10–29.

    Article  Google Scholar 

  8. Varadarajan R, Edge SB, Yu J, et al. Prognosis of occult breast carcinoma presenting as isolated axillary nodal metastasis. Oncology. 2006;71:456–9.

    Article  PubMed  Google Scholar 

  9. Baron PL, Moore MP, Kinne DW, Candela FC, Osborne MP, Petrek JA. Occult breast cancer presenting with axillary metastases. Arch Surg. 1990;125:210–4.

    Article  CAS  PubMed  Google Scholar 

  10. Cameron HC. Some clinical facts regarding mammary cancer. Br Med J. 1909;1:577–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology. Breast Cancer. v2.2015. Available at http://www.nccn.org.

  12. Barton SR, Smith IE, Kirby AM, Ashley S, Walsh G, Parton M. The role of ipsilateral breast radiotherapy in management of occult primary breast cancer presenting as axillary lymphadenopathy. Eur J Cancer. 2011;47:2099–106.

    Article  PubMed  Google Scholar 

  13. Green FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, et al. American joint committee on cancer: cancer staging handbook. 6th ed. New York: Springer; 2002. p. 255–81.

    Google Scholar 

  14. Khandelwal AK, Garguilo GA. Therapeutic options for occult breast cancer: a survey of the American Society of Breast Surgeons and Review of the Literature. Am J Surg. 2005;190:609–13.

    Article  PubMed  Google Scholar 

  15. Walker GV, Smith GL, Perkins GH, Oh JL, Woodward W, Yu TK, et al. Population-based analysis of occult primary breast cancer with axillary lymph node metastasis. Cancer. 2010;116:4000–6.

    Article  PubMed  Google Scholar 

  16. Wang X, Zhao Y, Cao X. Clinical benefits of mastectomy on treatment of occult breast carcinoma presenting axillary metastases. Breast J. 2010;16(1):32–7.

    Article  PubMed  Google Scholar 

  17. Giuliano AE, McCall L, Beitsch P, Whitworth PW, Blumencranz P, Leitch AM, et al. Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial. Ann Surg. 2010;252(3):426–32.

    PubMed  Google Scholar 

  18. Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, et al. Alliance for Clinical Trials in Oncology. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA. 2013;310(14):1455–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC, USA

    Lejla Hadzikadic Gusic

  2. Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA

    Lejla Hadzikadic Gusic

  3. Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA

    Lejla Hadzikadic Gusic

  4. Division of Surgical Oncology, Department of Surgery, Magee-Womens Hospital, UPMC, Pittsburgh, PA, USA

    Ronald Johnson

Authors
  1. Lejla Hadzikadic Gusic
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  2. Ronald Johnson
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Editor information

Editors and Affiliations

  1. Oncology Institute, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Adnan Aydiner

  2. Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Abdullah Igci

  3. Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Magee-Women’s Hospital of UPMC, Pittsburgh, PA, USA

    Atilla Soran

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Gusic, L.H., Johnson, R. (2019). Occult Primary Breast Cancer with Axillary Metastases. In: Aydiner, A., Igci, A., Soran, A. (eds) Breast Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-16792-9_20

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  • DOI: https://doi.org/10.1007/978-3-030-16792-9_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16791-2

  • Online ISBN: 978-3-030-16792-9

  • eBook Packages: MedicineMedicine (R0)

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