Abstract
Chitosan is a deacetylated derivative of chitin. This polysaccharide has received a great attention due to its biocompatibility, low toxicity, biodegradable, furthermore can be used into different shapes, such as beads, hydrogels, powders, films and membranes. Chitosan hydrogels may be formed by different mechanisms, as physical association or chemically cross-linked, thus can vary its geometries, formulations and shapes. Usually, hydrogels are prepared using a conventional sol-gel process, where polymer is dissolved in dilute acid to form an aqueous solution, after complete dissolution the cross-linking agents are subsequently incorporated, and the solution/gel transition depends on the number cross-links between the polymer chains and the cross-linking agents, and these should be enough until reaching the formation of a network. The chitosan hydrogels are formed from cross-linking of hydrogen bonds, hydrophilic interactions and crystalline groups of chitosan present in the sol-gel.
Chitosan hydrogels have been largely used in drug delivery systems, wastewater and dye remediation, and tissue engineering supporting cell attachment and growth. In the food industry, chitosan hydrogels are used to maintain and/or improve the perception of flavor, release of fragrance compounds and increase shelf life. In the biomedical and biotechnological fields, these are used for controlled release formulations, for example, of compounds chemicals, volatiles, or proteins. Chitosan hydrogels can be used in dressing to adsorb the secretion of the injured area and release water on the wound surface, thus keeping it hydrated. Thus, the researches for employment of this material have been increasingly developed due to its favorable properties, such as durability, permeability, flexibility and its wide applicability.
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References
Abd El-Malek FF, Yousef AS, El-Assar SA (2017) Hydrogel film loaded with new formula from manuka honey for treatment of chronic wound infections. J Glob Antimicrob Resist 11:171–176. https://doi.org/10.1016/j.jgar.2017.08.007
Afshari MJ, Sheikh N, Afarideh H (2015) PVA/CM-chitosan/honey hydrogels prepared by using the combined technique of irradiation followed by freeze-thawing. Radiat Phys Chem 113:28–35. https://doi.org/10.1016/j.radphyschem.2015.04.023
Al Sagheer FA, Al-Sughayer MA, Muslim S, Elsabee MZ (2009) Extraction and characterization of chitin and chitosan from marine sources in Arabian Gulf. Carbohydr Polym 77:410–419. https://doi.org/10.1016/j.carbpol.2009.01.032
Allouche FN, Guibal E, Mameri N (2014) Preparation of a new chitosan–based material and its application for mercury sorption. Colloids Surf A Physicochem Eng Asp 446:224–232. https://doi.org/10.1016/j.colsurfa.2014.01.025
Anitha A, Sowmya S, Kumar PTS (2014) Chitin and chitosan in selected biomedical applications. Prog Polym Sci 39:1644–1667. https://doi.org/10.1016/j.progpolymsci.2014.02.008
Baghaie S, Khorasani MT, Zarrabi A, Moshtaghian J (2017) Wound healing properties of PVA/starch/chitosan hydrogel membranes with nano zinc oxide as antibacterial wound dressing material. J Biomater Sci Polym Ed 28:2220–2241. https://doi.org/10.1080/09205063.2017.1390383
Baysal K, Aroguz AZ, Adiguzel Z, Baysal BM (2013) Chitosan/alginate crosslinked hydrogels: preparation, characterization and application for cell growth purposes. Int J Biol Macromol 59:342–348. https://doi.org/10.1016/j.ijbiomac.2013.04.073
Berger J, Reist M, Mayer JM, Felt O, Gurny R (2004) Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 57:35–52. https://doi.org/10.1016/S0939-6411(03)00160-7
Berger R, Christina T, Miranda A, Pessoa P, Barbosa MA, Lima D, Manuela M, Pintado E, Saraiva MP (2018) Chitosan produced from mucorales fungi using agroindustrial by-products and its efficacy to inhibit colletotrichum species. Int J Biol Macromol 108:635–641. https://doi.org/10.1016/j.ijbiomac.2017.11.178
Bessa-Junior AP, Gonçalves AA (2013) Análises econômica e produtiva da quitosana extraída do exoesqueleto de camarão. Acta Fish Aquat Res 1:13–28. https://doi.org/10.2312/Actafish.2013.1.1.13-28
Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 62:83–99. https://doi.org/10.1016/j.addr.2009.07.019
Brack HP, Tirmizi SA, Risen WM Jr (1997) A spectroscopic and viscometric study of the metal ion-induced gelation of the biopolymer chitosan. Polymer 38:2351–2362. https://doi.org/10.1016/S0032-3861(96)00780-X
Bueno CZ, Dias AMA, Sousa HJC, Braga MEM, Moraes AM (2014) Control of the properties of porous chitosan–alginate membranes through the addition of different proportions of Pluronic F68. Mater Sci Eng C 44:117–125. https://doi.org/10.1016/j.msec.2014.08.014
Campana-Filho SP, Britto DD, Curti E, Abreu FR, Cardoso MB, Battisti MV, Sim PC, Goy RC, Signini R, Lavall RL (2007) Extraction, structures and properties of alpha-and beta-chitin. Quim Nova 30:644–650. https://doi.org/10.1590/S0100-40422007000300026
Carvalho IC, Mansur HS (2017) Engineered 3D-scaffolds of photocrosslinked chitosan-gelatin hydrogel hybrids for chronic wound dressings and regeneration. Mater Sci Eng C 78:690–705. https://doi.org/10.1016/j.msec.2017.04.126
Chandra R, Rustgi R (1998) Biodegradable polymers. Prog Polym Sci 23:1273–1335. https://doi.org/10.1016/S0079-6700(97)00039-7
Chatterjee S, Lee MW, Woo SH (2010) Adsorption of congo red by chitosan hydrogel beads impregnated with carbon nanotubes. Bioresour Technol 101:1800–1806. https://doi.org/10.1016/j.biortech.2009.10.051
Chen AH, Chen SM (2009) Biosorption of azo dyes from aqueous solution by glutaraldehyde-crosslinked chitosans. J Hazard Mater 172:1111–1121. https://doi.org/10.1016/j.jhazmat.2009.07.104
Chen Y, Ru J, Geng B, Wang H, Tong C, Du C, Wu S, Liu H (2017) Chargefunctionalized and mechanically durable composite cryogels from Q-NFC and CS for highly selective removal of anionic dyes. Carbohydr Polym 174:841–848. https://doi.org/10.1016/j.carbpol.2017.07.024
Cheung RCF, Ng TB, Wong JH, Chan WY (2015) Chitosan: an update on potential biomedical and pharmaceutical applications. Mar Drugs 13:5156–5186. https://doi.org/10.3390/md13085156
Crini G, Badot PM (2008) Application of chitosan, a natural aminopolysaccharide, for dye removal from aqueous solutions by adsorption processes using batch studies: a review of recent literature. Prog Polym Sci 33:399–447. https://doi.org/10.1016/j.progpolymsci.2007.11.001
Croisier F, Jérôme C (2013) Chitosan-based biomaterials for tissue engineering. Eur Polym J 49:780–792. https://doi.org/10.1016/j.eurpolymj.2012.12.009
Dash M, Chiellini F, Ottenbrite RM, Chiellini E (2011) Chitosan – a versatile semi–synthetic polymer in biomedical applications. Prog Polym Sci 36:981–1014. https://doi.org/10.1016/j.progpolymsci.2011.02.001
Denavi G, Tapia-blácido DR, Anon MC, Sobral PJA, Mauri NA, Menegalli FC (2009) Effects of drying conditions on some physical properties of soy protein films. J Food Eng 90:341–349. https://doi.org/10.1016/j.jfoodeng.2008.07.001
Dotto GL, Souza VC, Pinto LAA (2011) Drying of chitosan in a spouted bed: the influences of temperature and equipment geometry in powder quality. LWT Food Sci Technol 44:1786–1792. https://doi.org/10.1016/j.cej.2012.10.027
Dotto GL, Moura JMD, Cadaval TRS, Pinto LAA (2013) Application of chitosan films for the removal of food dyes from aqueous solutions by adsorption. Chem Eng J 214:8–16. https://doi.org/10.1016/j.cej.2012.10.027
Drury JL, Mooney DJ (2003) Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 24:4337–4351. https://doi.org/10.1016/S0142-9612(03)00340-5
El Knidri H, Belaabed A, Adaou A, Laajeb A, Lahsini A (2019) Extraction, chemical modification and characterization of chitin and chitosan: a review. Int J Biol Macromol 120:1181–1189. https://doi.org/10.1016/j.ijbiomac.2018.08.139
FAO – Food and Agriculture Organization the United Nations (2018) The state of world fisheries and aquaculture. FAO/UN, Rome
Ferfera-Harrar H, Aiouaz N, Dairi N (2015) Synthesis and properties of chitosan-graft polyacrylamide/gelatin superabsorbent composites for wastewater purification. Chem Mole Eng 9:849–856. https://doi.org/10.5281/zenodo.1107848
Fujiwara J, Iwanami T, Takahashi M, Tanaka R, Hatakeyama T, Hatakeyama H (2000) Structural change of xanthan gum association in aqueous solutions. Thermochim Acta 241:352–353. https://doi.org/10.1016/S0040-6031(99)00472-4
Furuike T, Komoto D, Hashimoto H, Tamura H (2017) Preparation of chitosan hydrogel and its solubility in organic acids. Int J Biol Macromol 104:1620–1625. https://doi.org/10.1016/j.ijbiomac.2017.02.099
George M, Abraham TE (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan – a review. J Control Release 114:1–14. https://doi.org/10.1016/j.jconrel.2006.04.017
Gilarska A, Lewandowska-Łańcucka J, Horak W, Nowakowska M (2018) Collagen/chitosan/hyaluronic acid – based injectable hydrogels for tissue engineering applications – design, physicochemical and biological characterization. Colloids Surf B: Biointerfaces 170:152–162
Ginani MF, Navarro MV, Nascimento EGD, Oliveira UO (1999) The study of influence of crosslinking and organic additives on the behavior of chitosan gels. Quim Nova 22:801–804. https://doi.org/10.1590/S0100-40421999000600005
Gonçalves JO, Dotto GL, Pinto LA (2015) Cyanoguanidine-crosslinked chitosan to adsorption of food dyes in the aqueous binary system. J Mol Liq 211:425–430. https://doi.org/10.1016/j.molliq.2015.07.061
Gonçalves JO, Santos JP, Rios EC, Crispim MM, Dotto GL, Pinto LAA (2017) Development of chitosan based hybrid hydrogels for dyes removal from aqueous binary system. J Mol Liq 225:265–270. https://doi.org/10.1016/j.molliq.2016.11.067
Guibal E (2004) Interactions of metal ions with chitosan-based sorbents: a review. Sep Purif Technol 38:43–74. https://doi.org/10.1016/j.seppur.2003.10.004
Guo M, Li X (2016) Development of porous Ti6Al4V/chitosan sponge composite scaffold for orthopedic applications. Mater Sci Eng C 58:1177–1181. https://doi.org/10.1016/j.msec.2015.09.061
Gupta VK (2009) Application of low-cost adsorbents for dye removal: a review. J Environ Manag 90:2313–2342. https://doi.org/10.1016/j.jenvman.2008.11.017
Hamidi M, Azadi A, Rafiei P (2008) Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev 60:1638–1649. https://doi.org/10.1016/j.addr.2008.08.002
Huang B, Liu M, Zhou C (2017) Chitosan composite hydrogels reinforced with natural clay nanotubes. Carbohydr Polym 175:689–698. https://doi.org/10.1016/j.carbpol.2017.08.039
Ishihara M, Fujita M, Obara K, Hattori H, Nakamura S, Nambu M, Kiyosawa T, Kanatani Y, Takase B, Kikuchi M, Maehara T (2006) Controlled releases of FGF-2 and paclitaxel from chitosan hydrogels and their subsequent effects on wound repair, angiogenesis, and tumor growth. Curr Drug Deliv 3:351–358
Jayakumar R, Prabaharan M, Sudheesh KPT, Nair SV, Tamura H (2011) Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv 29:322–337. https://doi.org/10.1016/j.biotechadv.2011.01.005
Jiang X, Cheng L, Zhong W (2003) A new linear potentiometric titration method for the determination of deacetylation degree of chitosan. Carbohydr Polym 54:457–463. https://doi.org/10.1016/j.carbpol.2003.05.004
Kakkar P, Madhan B (2016) Fabrication of keratin-silica hydrogel for biomedical applications. Mater Sci Eng C 66:78–184. https://doi.org/10.1016/j.msec.2016.04.067
Kakkar P, Verma S, Manjubala I, Madhan B (2014) Development of keratin–chitosan–gelatin composite scaffold for soft tissue engineering. Mater Sci Eng C 45:343–347. https://doi.org/10.1016/j.msec.2014.09.021
Kildeeva NR, Perminov PA, Vladimirov LV, Novikov VV, Mikhailov SN (2009) About mechanism of chitosan cross-linking with glutaraldehyde. Russ J Bioorg Chem 35:360–369. https://doi.org/10.1134/s106816200903011x
Kim IY, Seo SJ, Moon HS, Yoo MK, Park IY, Kim BC, Cho CS (2008) Chitosan and its derivatives for tissue engineering applications. Biotechnol Adv 26:1–21. https://doi.org/10.1016/j.biotechadv.2007.07.009
Kumar MR, Muzzarelli R, Muzzarelli C, Sashiwa H, Domb AJ (2004) Chitosan chemistry and pharmaceutical perspectives. Chem Rev 104:6017–6084. https://doi.org/10.1021/cr030441b
Kuroiwa T, Takada H, Shogen A, Saito K, Kobayashi I, Uemura K, Kanazawa A (2017) Cross-linkable chitosan-based hydrogel microbeads with pH-responsive adsorption properties for organic dyes prepared using size-tunable microchannel emulsification technique. Colloids Surf A Physicochem Eng Asp 514:69–78. https://doi.org/10.1016/j.colsurfa.2016.11.046
Lan G, Lu B, Wang T, Wang L, Chen J, Yu K, Wu D (2015) Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent. Colloids Surf B: Biointerfaces 136:1026–1034. https://doi.org/10.1016/j.colsurfb.2015.10.039
Li Q, Yang D, Ma G, Xu Q, Chen X, Lu F, Nie J (2009) Synthesis and characterization of chitosan-based hydrogels. Int J Biol Macromol 44:121–127. https://doi.org/10.1016/j.ijbiomac.2008.11.001
Lin CC, Metters AT (2006) Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev 58:1379–1408. https://doi.org/10.1016/j.addr.2006.09.004
Liu Y (2009) Is the free energy change of adsorption correctly calculated. J Chem Eng Data 54:1981–1985. https://doi.org/10.1021/je800661q
Lu B, Wang T, Li Z, Dai F, Lv L, Tang F, Lan G (2016) Healing of skin wounds with a chitosan–gelatin sponge loaded with tannins and platelet–rich plasma. Int J Biol Macromol 82:884–891. https://doi.org/10.1016/j.ijbiomac.2015.11.009
Maciel VBV, Yoshida CM, Franco TT (2015) Chitosan/pectin polyelectrolyte complex as a pH indicator. Carbohydr Polym 132:537–545. https://doi.org/10.1016/j.carbpol.2015.06.047
Mahdavinia GR, Pourjavadi A, Hosseinzadeh H, Zohuriaan MJ (2004) Modified chitosan 4. Superabsorbent hydrogels from poly (acrylic acid-co-acrylamide) grafted chitosan with salt-and pH-responsiveness properties. Eur Polym J 40:1399–1407. https://doi.org/10.1016/j.eurpolymj.2004.01.039
Mahmoud AA, Salam AA (2016) Norfloxacin–loaded collagen/chitosan scaffolds for skin reconstruction: preparation, evaluation and in–vivo wound healing assessment. Eur J Pharm Sci 83:155–165. https://doi.org/10.1016/j.ejps.2015.12.026
Miranda DG, Malmonge SM, Campos DM, Attik NG, Grosgogeat B, Gritsch K (2016) A chitosan-hyaluronic acid hydrogel scaffold for periodontal tissue engineering. J Biomed Mater Res B Appl Biomater 104:1691–1702. https://doi.org/10.1002/jbm.b.33516
Moura JM, Farias BS, Rodrigues DA, Moura CM, Dotto GL, Pinto LAA (2015) Preparation of chitosan with different characteristics and its application for biofilms production. J Polym Environ 23:470–477
Mozalewska W, Czechowska-Biskup R, Olejnik AK, Wach RA, Ulański P, Rosiak JM (2017) Chitosan-containing hydrogel wound dressings prepared by radiation technique. Radiat Phys Chem 134:1–7. https://doi.org/10.1016/j.radphyschem.2017.01.003
Muzzarelli RAA (1997) Human enzymatic activities related to the therapeutic administration of chitin derivatives. Cell Mol Life Sci 53:131–140
Muzzarelli RAA, Rocchetti R (1986) The determination of the degree of acetylation of chitosans by spectrophotometry. In: RAA M, Jeuniaux C, Gooday GW (eds) Chitin in nature and technology. Springer US, Boston, pp 385–388
Nettles DL, Elder SH, Gilbert JA (2002) Potential use of chitosan as a cell scaffold material for cartilage tissue engineering. Tissue Eng 8:1009–1016. https://doi.org/10.1089/107632702320934100
Ngah WW, Teong LC, Hanafiah MAKM (2011) Adsorption of dyes and heavy metal ions by chitosan composites: a review. Carbohydr Polym 83:1446–1456. https://doi.org/10.1016/j.carbpol.2010.11.004
Pakdel PM, Peighambardoust SJ (2018) Review on recent progress in chitosan-based hydrogels for wastewater treatment application. Carbohydr Polym 201:264–279. https://doi.org/10.1016/j.carbpol.2018.08.070
Paloma MT, Yewande E, Guillermo T, Susana T (2003) Release of amoxicillin from polyionic complexes of chitosan and poly (acrylic acid): study of polymer/polymer and polymer/drug interactions within the network structure. Biomaterials 24:1499–1506. https://doi.org/10.1016/S0142-9612(02)00512-4
Patrulea V, Ostafe V, Borchard G, Jordan O (2015) Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm 97:417–426. https://doi.org/10.1016/j.ejpb.2015.08.004
Pellá MG, Lima-Tenório MK, Tenório-Neto ET, Guilherme MR, Muniz EC, Rubira AF (2018) Chitosan-based hydrogels: from preparation to biomedical applications. Carbohydr Polym 196:233–245. https://doi.org/10.1016/j.carbpol.2018.05.033
Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27–46. https://doi.org/10.1016/S0939-6411(00)00090-4
Poon L, Wilson LD, Headley JV (2014) Chitosan-glutaraldehyde copolymers and their sorption properties. Carbohydr Polym 109:92–101. https://doi.org/10.1016/j.carbpol.2014.02.086
Prashanth KH, Tharanathan RN (2007) Chitin/chitosan: modifications and their unlimited application potential—an overview. Trends Food Sci Technol 18:117–131. https://doi.org/10.1016/j.tifs.2006.10.022
Qiao X, Peng X, Qiao J, Jiang Z, Han B, Yang C, Liu W (2017) Evaluation of a photocrosslinkable hydroxyethyl chitosan hydrogel as a potential drug release system for glaucoma surgery. J Mater Sci Mater Med 28:149. https://doi.org/10.1007/s10856-017-5954-z
Ratner BD, Hoffman A, Schoen FJ, Lemons JE (eds) (1996) Biomaterials science: an introduction to materials in medicine. Academic, San Diego. 484p
Rinaudo M (2006) Chitin and chitosan: properties and applications. Prog Polym Sci 31:603–632. https://doi.org/10.1016/j.progpolymsci.2006.06.001
Riva R, Ragelle H, Rieux A, Duhem N, Jérôme C, Préat V (2011) Chitosan and chitosan derivatives in drug delivery and tissue engineering. In: Rangasamy J, Prabaharan M, Muzzarelli RAA (eds) Chitosan for biomaterials II. Springer, Berlin/Heidelberg, pp 19–44
Santos CC, Mouta R, Junior MCC, Santana SAA, Silva HAS, Bezerra CWB (2018) Chitosan-edible oil based materials as upgraded adsorbents for textile dyes. Carbohydr Polym 180:182–191. https://doi.org/10.1016/j.carbpol.2017.09.076
Shen C, Shen Y, Wen Y, Wang H, Liu W (2011) Fast and highly efficient removal of dyes under alkaline conditions using magnetic chitosan-Fe (III) hydrogel. Water Res 45:5200–5210. https://doi.org/10.1016/j.watres.2011.07.018
Sousa KS, Silva Filho EC, Airoldi C (2009) Ethylenesulfide as a useful agent for incorporation into the biopolymer chitosan in a solvent-free reaction for use in cation removal. Carbohydr Res 344:1716–1723. https://doi.org/10.1016/j.carres.2009.05.028
Tan HB, Wang FY, Din W, Zhang Y, Ding J, Cai DX, Yu KF, Yang J, Yang L, Xu YQ (2015) Fabrication and evaluation of porous keratin/chitosan (kcs) scaffolds for effectively accelerating wound healing. Biomed Environ Sci 28:178–189. https://doi.org/10.3967/bes2015.024
Tentor FR, Oliveira JH, Scariot DB, Lazarin-Bidóia D, Bonafé EG, Nakamura CV, Martins AF (2017) Scaffolds based on chitosan/pectin thermosensitive hydrogels containing gold nanoparticles. Int J Biol Macromol 102:1186–1194. https://doi.org/10.1016/j.ijbiomac.2017.04.106
Tsuchida E, Abe K (1982) Interactions between macromolecules in solution and Intermacromolecular complexes. Springer, Berlin/Heidelberg, pp 1–119
Vakili M, Rafatullah M, Salamatinia B, Abdullah AZ, Ibrahim MH, Tan KB, Amouzgar P (2014) Application of chitosan and its derivatives as adsorbents for dye removal from water and wastewater: a review. Carbohydr Polym 113:115–130. https://doi.org/10.1016/j.carbpol.2014.07.007
Vakili M, Rafatullah M, Ibrahim MH, Abdullah AZ, Salamatinia B, Gholami Z (2016) Chitosan hydrogel beads impregnated with hexadecylamine for improved reactive blue 4 adsorption. Carbohydr Polym 137:139–146. https://doi.org/10.1016/j.carbpol.2015.09.017
Venkatesan J, Kim SK (2010) Chitosan composites for bone tissue engineering – an overview. Mar Drugs 8:2252–2266. https://doi.org/10.3390/md8082252
Weska RF, Moura JM, Batista LM, Rizzi J, Pinto LAA (2007) Optimization of deacetylation in the production of chitosan from shrimp wastes: use of response surface methodology. J Food Eng 80:749–753. https://doi.org/10.1016/j.jfoodeng.2006.02.006
Wu ACM (1988) Determination of molecular-weight distribution of chitosan by high-performance liquid chromatography. Methods Enzymol 161:447–452. https://doi.org/10.1016/0076-6879(88)61055-X
Xie W, Gao Q, Guo Z, Wang D, Gao F, Wang X, Zhao L (2017) Injectable and self-healing thermosensitive magnetic hydrogel for asynchronous control release of doxorubicin and docetaxel to treat triple-negative breast cancer. ACS Appl Mater Interfaces 9:33660–33673. https://doi.org/10.1021/acsami.7b10699
Xing J, Wang X, Xun J, Peng J, Xu Q, Zhang W, Lou T (2018) Preparation of micro-nanofibrous chitosan sponges with ternary solvents for dye adsorption. Carbohydr Polym 198:69–75. https://doi.org/10.1016/j.carbpol.2018.06.064
Xu Y, Yuan S, Han J, Lin H, Zhang X (2017a) Design and fabrication of a chitosan hydrogel with gradient structures via a step-by-step cross-linking process. Carbohydr Polym 176:195–202. https://doi.org/10.1016/j.carbpol.2017.08.032
Xu Y, Han J, Lin H (2017b) Fabrication and characterization of a self-crosslinking chitosan hydrogel under mild conditions without the use of strong bases. Carbohydr Polym 156:372–379. https://doi.org/10.1016/j.carbpol.2016.09.046
Yang B, Li X, Shi S, Kong X, Guo G, Huang M, Qian Z (2010) Preparation and characterization of a novel chitosan scaffold. Carbohydr Polym 80:860–865. https://doi.org/10.1016/j.carbpol.2009.12.044
Yuvarani I, Senthilkumar S, Venkatesan J, Kim SK, Al-Kheraif AA, Anil S, Sudha PN (2015) Chitosan modified alginate-polyurethane scaffold for skeletal muscle tissue engineering. J Biomater Tissue Eng 5:665–672. https://doi.org/10.1166/jbt.2015.1358
Zargar V, Asghari M, Dashti A (2015) A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications. ChemBioEng Rev 2:204–226. https://doi.org/10.1002/cben.201400025
Zhang H, Neau SH (2001) In vitro degradation of chitosan by a commercial enzyme preparation: effect of molecular weight and degree of deacetylation. Biomaterials 22:1653–1658
Zhang L, Zeng Y, Cheng Z (2016) Removal of heavy metal ions using chitosan and modified chitosan: a review. J Mol Liq 214:175–191. https://doi.org/10.1016/j.molliq.2015.12.013
Zheng L, Wang C, Shu Y, Yan X, Li L (2015) Utilization of diatomite/chitosan–Fe (III) composite for the removal of anionic azo dyes from wastewater: equilibrium, kinetics and thermodynamics. Colloids Surf A Physicochem Eng Asp 468:129–139. https://doi.org/10.1016/j.colsurfa.2014.12.015
Zhou LC, Meng XG, Fu JW, Yang YC, Yang P, Mi C (2014) Highly efficient adsorption of chlorophenols onto chemically modified chitosan. Appl Surf Sci 292:735–741. https://doi.org/10.1016/j.colsurfa.2014.12.015
Zhu Y, Zheng Y, Wang F, Wang A (2016) Fabrication of magnetic macroporous chitosan-g-poly (acrylic acid) hydrogel for removal of Cd2+ and Pb2+. Int J Biol Macromol 93:483–492. https://doi.org/10.1016/j.ijbiomac.2016.09.005
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The authors would like to thank CAPES (Coordination for the Improvement of Higher Education Personnel)–Finance Code: 001 and CNPq (National Council for Scientific and Technological Development) for the financial support.
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Gonçalves, J.O., Esquerdo, V.M., Sant’Anna Cadaval, T.R., de Almeida Pinto, L.A. (2019). Chitosan-Based Hydrogels. In: Crini, G., Lichtfouse, E. (eds) Sustainable Agriculture Reviews 36. Sustainable Agriculture Reviews, vol 36. Springer, Cham. https://doi.org/10.1007/978-3-030-16581-9_5
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