Present and Future in Personalized Clinical and Laboratory Approaches to In Vitro Fertilization Procedures

Radojčić Badovinac, Anđelka; Smiljan Severinski, Neda; Dević Pavlić, Sanja

doi:10.1007/978-3-030-16465-2_8

Anđelka Radojčić Badovinac⁹,
Neda Smiljan Severinski¹⁰ &
Sanja Dević Pavlić⁹

Part of the book series: Europeanization and Globalization ((EAG,volume 5))

649 Accesses

Abstract

Personalized approach to a patient engaged into an infertility treatment has been present since the early beginnings of the assisted reproductive technologies, and is constantly developing because of the progress of therapy, medication and laboratory methods. Personalization of the infertility treatment can be discussed on three different levels: approach to the patient, selection of gametes and assessment of embryos. Personalization of the approach to the patient includes adjustment of controlled ovarian stimulation strategy as well as usage of the biomarkers for the ovarian response to the hormone stimulation. Regarding gametes and embryo assessment, personalization includes application of novel OMICS and other high-throughput methods for selection of the oocytes and/or embryos with the highest developmental potential. Personalization of the treatment approaches and ovarian stimulation protocols along with improved laboratory techniques would lead to better treatment efficiency with improved safety for the patient, higher percentage of babies born per cycle and higher cumulative live birth rate for couple in shorter period of time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 149.00; Price excludes VAT (USA)

Softcover Book: USD 199.99; Price excludes VAT (USA)

Hardcover Book: USD 199.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

1.
Gameiro et al. (2012).
2.
Broer et al. (2011, 2013).
3.
Ferraretti et al. (2011), La Marca et al. (2015), and Polyzos et al. (2014).
4.
Drakopoulos et al. (2016).
5.
Simoni and Casarini (2014).
6.
Mohiyiddeen et al. (2012).
7.
Benkhalifa et al. (2015), Bromer and Seli (2008), and Uyar et al. (2013).
8.
Rienzi et al. (2012).
9.
Revelli et al. (2009).
10.
Dumesic et al. (2015).
11.
Egea et al. (2014).
12.
Chronowska (2014).
13.
Gardner et al. (2001), and Gardner (2015).
14.
Kaser and Racowsky (2014).
15.
Ravichandran et al. (2017).

References

Benkhalifa M, Madkour A et al (2015) From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome. Expert Rev Proteomics 12(4):407–423. https://doi.org/10.1586/14789450.2015.1056782
Article Google Scholar
Broer SL, Dólleman M et al (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17(1):46–54. https://doi.org/10.1093/humupd/dmq034
Article Google Scholar
Broer SL, Dólleman M et al (2013) Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis. Fertil Steril 100(2):420–429. https://doi.org/10.1016/j.fertnstert.2013.04.024
Article Google Scholar
Bromer JG, Seli E (2008) Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Curr Opin Obstet Gynecol 20(3):234–241. https://doi.org/10.1097/GCO.0b013e3282fe723d
Article Google Scholar
Chronowska E (2014) High-throughput analysis of ovarian granulosa cell transcriptome. Biomed Res Int 2014:213570. https://doi.org/10.1155/2014/213570
Article Google Scholar
Drakopoulos P, Blockeel C et al (2016) Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod 31(2):370–376. https://doi.org/10.1093/humrep/dev316
Article Google Scholar
Dumesic DA, Meldrum DR et al (2015) Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril 103(2):303–316. https://doi.org/10.1016/j.fertnstert.2014.11.015
Article Google Scholar
Egea RR, Puchalt NG et al (2014) OMICS: current and future perspectives in reproductive medicine and technology. J Hum Reprod Sci 7(2):73–92. https://doi.org/10.4103/0974-1208.138857
Article Google Scholar
Ferraretti AP, La Marca A et al (2011) ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 26(7):1616–1624. https://doi.org/10.1093/humrep/der092
Article Google Scholar
Gameiro S, Boivin J et al (2012) Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment. Hum Reprod Update 18(6):652–669. https://doi.org/10.1093/humupd/dms031
Article Google Scholar
Gardner DK (2015) Lactate production by the mammalian blastocyst: manipulating the microenvironment for uterine implantation and invasion? BioEssays 37(4):364–371. https://doi.org/10.1002/bies.201400155
Article Google Scholar
Gardner DK, Lane M et al (2001) Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil Steril 76(6):1175–1180
Article Google Scholar
Kaser DJ, Racowsky C (2014) Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: a systematic review. Hum Reprod Update 20(5):617–631. https://doi.org/10.1093/humupd/dmu023
Article Google Scholar
La Marca A, Grisendi V et al (2015) Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study. J Assist Reprod Genet 32(6):931–937. https://doi.org/10.1007/s10815-015-0476-4
Article Google Scholar
Mohiyiddeen L, Newman WG et al (2012) Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers. Fertil Steril 97(3):677–681. https://doi.org/10.1016/j.fertnstert.2011.12.040
Article Google Scholar
Polyzos NP, Nwoye M et al (2014) Live birth rates in Bologna poor responders treated with ovarian stimulation for IVF/ICSI. Reprod Biomed Online 28(4):469–474. https://doi.org/10.1016/j.rbmo.2013.11.010
Article Google Scholar
Ravichandran K, McCaffrey C et al (2017) Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers. Hum Reprod 6:1–11. https://doi.org/10.1093/humrep/dex070
Article Google Scholar
Revelli A, Delle Piane L et al (2009) Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol 7:40. https://doi.org/10.1186/1477-7827-7-40
Article Google Scholar
Rienzi L, Balaban B et al (2012) The oocyte. Hum Reprod 1:i2–i121. https://doi.org/10.1093/humrep/des200
Article Google Scholar
Simoni M, Casarini L (2014) Mechanisms in endocrinology: genetics of FSH action: a 2014-and-beyond view. Eur J Endocrinol 170(3):R91–R107. https://doi.org/10.1530/EJE-13-0624
Article Google Scholar
Uyar A, Torrealday S et al (2013) Cumulus and granulosa cell markers of oocyte and embryo quality. Fertil Steril 99(4):979–997. https://doi.org/10.1016/j.fertnstert.2013.01.129
Article Google Scholar

Download references

Author information

Authors and Affiliations

Department of Biotechnology, Centre for High-Throughput Technologies, University of Rijeka, Rijeka, Croatia
Anđelka Radojčić Badovinac & Sanja Dević Pavlić
Department of Obstetrics and Gynaecology, Clinical Hospital Centre Rijeka, Rijeka, Croatia
Neda Smiljan Severinski

Authors

Anđelka Radojčić Badovinac
View author publications
You can also search for this author in PubMed Google Scholar
Neda Smiljan Severinski
View author publications
You can also search for this author in PubMed Google Scholar
Sanja Dević Pavlić
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anđelka Radojčić Badovinac .

Editor information

Editors and Affiliations

Faculty of Law, University of Rijeka, Rijeka, Croatia
Nada Bodiroga-Vukobrat
Croatian Academy of Sciences and Arts, Rijeka, Croatia
Daniel Rukavina
Juraj Dobrila University of Pula, Faculty of Medicine, Pula, Croatia
Krešimir Pavelić
Department of Biotechnology, Centre for High-Throughput Technologies, University of Rijeka, Rijeka, Croatia
Krešimir Pavelić
University of Applied Sciences, Ludwigsburg, Germany
Gerald G. Sander

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Radojčić Badovinac, A., Smiljan Severinski, N., Dević Pavlić, S. (2019). Present and Future in Personalized Clinical and Laboratory Approaches to In Vitro Fertilization Procedures. In: Bodiroga-Vukobrat, N., Rukavina, D., Pavelić, K., Sander, G.G. (eds) Personalized Medicine in Healthcare Systems. Europeanization and Globalization, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-030-16465-2_8

Download citation

DOI: https://doi.org/10.1007/978-3-030-16465-2_8
Published: 03 August 2019
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-16464-5
Online ISBN: 978-3-030-16465-2
eBook Packages: Law and CriminologyLaw and Criminology (R0)

Publish with us

Policies and ethics