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Soft Tissue Sarcomas

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International Manual of Oncology Practice

Abstract

Soft tissue sarcomas (STS) are a heterogeneous group of malignant tumors of mesenchymal origin, accounting for less than 1% of all adult malignancies and 15% of pediatric cancers. The most common subtypes in adults are liposarcoma (which corresponds to 20% of all STS), leiomyosarcoma and undifferentiated pleomorphic sarcoma. Based on the pattern of dissemination and the risk of distant metastases a different imaging approach may be indicated for each STS subtype as a staging workup. However, a contrast enhanced chest computed tomography is recommended for all moderate or high grade STS as a baseline imaging. Surgery is the main treatment of localized STS. It is recommended that the resection of the primary tumor includes a 2 cm margin envelope of normal tissue surrounding the lesion. The indications for radiotherapy include: high grade tumors, large (>5 cm) proximal grade 2 tumors, head and neck STS, large or high grade retroperitoneal sarcomas, local recurrences or positive margins after surgery. Adjuvant chemotherapy is still not a consensus, but there are some histologies that are better responders, like: synovial sarcoma, myxoid or pleomorphic liposarcoma, leiomyosarcoma and undifferentiated pleomorphic sarcoma. Metastatic soft tissue sarcomas are basically treated with chemotherapy. However, as there is not any highly effective treatment for the metastatic disease, the prognostic factors for prolonged survival are more related to the tumor biology than to the treatment itself.

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References

  1. Miller RW, Young JL Jr, Novakovic B (1995) Childhood cancer. Cancer 75:395

    Article  CAS  PubMed  Google Scholar 

  2. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (2013) World health organization classification of tumours of soft tissue and bone, 4th edn. IARC Press, Lyon

    Google Scholar 

  3. Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68:7

    Article  PubMed  Google Scholar 

  4. DeVita VT, Lawrence TS (2011) Rosenberg SA Cancer: principles & practice of oncology, 9th edn. Wolters Kluwer Health/Lippincott. Williams & Wilkins, Philadelphia, p c201

    Google Scholar 

  5. Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds) (2017) SEER cancer statistics review, 1975–2014. National Cancer Institute, Bethesda

    Google Scholar 

  6. Brennan MF, Antonescu CR, Alektiar KM et al (2016) General description. In: Management of soft tissue sarcoma. Springer, New York, pp 6–8

    Chapter  Google Scholar 

  7. Brennan MF, Antonescu CR, Moraco N et al (2014) Lessons learned from the study of 10,000 patients with soft tissue sarcoma. Ann Surg 260(3):416–422

    Article  PubMed  Google Scholar 

  8. Stacy GS, Dixon LB (2007) Pitfalls in MR image interpretation prompting referrals to an orthopedic oncology clinic. Radiographics 27:805–828

    Article  PubMed  Google Scholar 

  9. Henderson TO, Whitton J, Stovall M et al (2007) Secondary sarcomas in childhood cancer survivors: a report from the childhood cancer survivor study. J Natl Cancer Inst 99(4):300–308

    Article  PubMed  Google Scholar 

  10. Riad S, Biau D, Holt GE et al (2012) The clinical and functional outcome for patients with radiation-induced soft tissue sarcoma. Cancer 118(10):2682–2692

    Article  PubMed  Google Scholar 

  11. Cahan WG, Woodard HQ, Higinbotham NL et al (1948) Sarcoma arising in irradiated bone; report of 11 cases. Cancer 1(1):3–29

    Article  CAS  PubMed  Google Scholar 

  12. Arlen M, Higinbotham NL, Huvos AG et al (1971) Radiation-induced sarcoma of bone. Cancer 28(5):1087–1099

    Article  CAS  PubMed  Google Scholar 

  13. Robinson E, Bleakney RR, Ferguson PC et al (2008) Oncodiagnosis panel: 2007 multidisciplinary management of soft tissue sarcoma. Radiographics 28:2069–2086

    Article  PubMed  Google Scholar 

  14. Aga P, Singh R, Parihar A et al (2011) Imaging spectrum in soft tissue sarcomas. Indian J Surg Oncol 2(4):271–279

    Article  PubMed  PubMed Central  Google Scholar 

  15. Amini B, Jessop AC, Ganeshan DM et al (2015) Contemporary imaging of soft tissue sarcomas. J Surg Oncol 111:496–503

    Article  PubMed  Google Scholar 

  16. Knapp EL, Kransdorf MJ, Letson GD (2005) Diagnostic imaging update: soft tissue sarcomas. Cancer Control 12(1):22–26

    Article  PubMed  Google Scholar 

  17. Varma DG (1999) Optimal radiologic imaging of soft tissue sarcomas. Semin Surg Oncol 17(1):2–10

    Article  CAS  PubMed  Google Scholar 

  18. Gilbert NF, Cannon CP, Lin PP et al (2009) Soft-tissue sarcoma. J Am Acad Orthop Surg 17(1):40–47

    Article  PubMed  Google Scholar 

  19. Caracciolo JT, Letson GD (2016) Radiologic approach to bone and soft tissue sarcomas. Surg Clin North Am 96(5):963–976

    Article  PubMed  Google Scholar 

  20. Verheijen P, Witjes H, van Gorp J, Hennipman A, van Dalen T (2010) Current pathology work-up of extremity soft tissue sarcomas, evaluation of the validity of different techniques. Eur J Surg Oncol 36(1):95–99

    Article  CAS  PubMed  Google Scholar 

  21. Heslin MJ, Lewis JJ, Woodruff JM, Brennan MF (1997) Core needle biopsy for diagnosis of extremity soft tissue sarcoma. Ann Surg Oncol 4(5):425–431

    Article  CAS  PubMed  Google Scholar 

  22. Strauss DC, Qureshi YA, Hayes AJ, Thway K, Fisher C, Thomas JM (2010) The role of core needle biopsy in the diagnosis of suspected soft tissue tumours. J Surg Oncol 102(5):523–529

    Article  CAS  PubMed  Google Scholar 

  23. Woon DT, Serpell JW (2008) Preoperative core biopsy of soft tissue tumours facilitates their surgical management: a 10-year update. ANZ J Surg 78(11):977–981

    Article  PubMed  Google Scholar 

  24. Serpell JW, Pitcher ME (1998) Pre-operative core biopsy of soft-tissue tumours facilitates their surgical management. Aust N Z J Surg 68(5):345–349

    Article  CAS  PubMed  Google Scholar 

  25. Jaques DP, Coit DG, Casper ES, Brennan MF (1995) Hepatic metastases from soft-tissue Sarcoma. Ann Surg 221(4):392–397

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Bold R, Benjamin R, Feig B, Hunt KK, Pearlstone DB, Pisters PW, Patel S, Pollack A, Pollock RE, Yasko AW (1999) Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up. Cancer 85(1):85–92

    Article  PubMed  Google Scholar 

  27. Eilber FR, Eckardt J (1997) Surgical management of soft tissue sarcomas. Semin Oncol 24(5):526–533

    CAS  PubMed  Google Scholar 

  28. Tanabe KK, Pollock RE, Ellis LM, Murphy A, Sherman N, Romsdahl MM (1994) Influence of surgical margins on outcome in patients with preoperatively irradiated extremity soft tissue sarcomas. Cancer 73(6):1652–1659

    Article  CAS  PubMed  Google Scholar 

  29. Ferguson PC, Griffin AM, O’Sullivan B, Catton CN, Davis AM, Murji A, Bell RS, Wunder JS (2006) Bone invasion in extremity soft-tissue sarcoma: impact on disease outcomes. Cancer 106(12):2692–2700

    Article  PubMed  Google Scholar 

  30. Cannon CP, Ballo MT, Zagars GK, Mirza AN, Lin PP, Lewis VO, Yasko AW, Benjamin RS, Pisters PW (2006) Complications of combined modality treatment of primary lower extremity soft-tissue sarcomas. Cancer 107(10):2455–2461

    Article  PubMed  Google Scholar 

  31. Holt GE, Griffin AM, Pintilie M, Wunder JS, Catton C, O’Sullivan B, Bell RS (2005) Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy. J Bone Joint Surg Am 87(2):315–319

    Article  PubMed  Google Scholar 

  32. Gortzak Y, Lockwood GA, Mahendra A, Wang Y, Chung PW, Catton CN, O’Sullivan B, Deheshi BM, Wunder JS, Ferguson PC (2010) Prediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh. Cancer 116(6):1553–1559

    Article  PubMed  Google Scholar 

  33. Nishinari K, Krutman M, Aguiar Junior S, Pignataro BS, Yazbek G, Zottele Bomfim GA, Teivelis MP, Wolosker N (2015) Surgical outcomes of vascular reconstruction in soft tissue sarcomas of the lower extremities. J Vasc Surg 62(1):143–149

    Article  PubMed  Google Scholar 

  34. Crago AM, Lee AY (2016) Multimodality management of soft tissue tumors in the extremity. Surg Clin North Am 96(5):977–992

    Article  PubMed  PubMed Central  Google Scholar 

  35. Andreou D, Boldt H, Werner M et al (2013) Sentinel node biopsy in soft tissue sarcoma subtypes with a high propensity for regional lymphatic spread: results of a large prospective trial. Ann Oncol 24(5):1400–1405

    Article  CAS  PubMed  Google Scholar 

  36. Grunhagen DJ, de Wilt JH, Graveland WJ, Verhoef C, van Geel AN, Eggermont AM (2006) Outcome and prognostic factor analysis of 217 consecutive isolated limb perfusions with tumor necrosis factor-alpha and melphalan for limb-threatening soft tissue sarcoma. Cancer 106(8):1776–1784

    Article  CAS  PubMed  Google Scholar 

  37. Pennacchioli E, Deraco M, Mariani L, Fiore M, Mussi C, Collini P, Olmi P, Casali PG, Santinami M, Gronchi A (2007) Advanced extremity soft tissue sarcoma: prognostic effect of isolated limb perfusion in a series of 88 patients treated at a single institution. Ann Surg Oncol 14(2):553–559

    Article  PubMed  Google Scholar 

  38. Brady MS, Brown K, Patel A, Fisher C, Marx W (2009) Isolated limb infusion with melphalan and dactinomycin for regional melanoma and soft-tissue sarcoma of the extremity: final report of a phase II clinical trial. Melanoma Res 19(2):106–111

    Article  PubMed  Google Scholar 

  39. Wagner MJ, Amodu LI, Duh MS et al (2015) A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments. BMC Cancer 15:175

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Predina JD, Puc MM, Bergey MR et al (2011) Improved survival after pulmonary metastasectomy for soft tissue sarcoma. J Thorac Oncol 6:913–919

    Article  PubMed  Google Scholar 

  41. Leahy M, Garcia Del Muro X, Reichardt P et al (2012) Chemotherapy treatment patterns and clinical outcomes in patients with metastatic soft tissue sarcoma. The Sarcoma treatment and burden of illness in North America and Europe (SABINE) study. Ann Oncol 23:2763–2770

    Article  CAS  PubMed  Google Scholar 

  42. Gossot D, Radu C, Girard P et al (2009) Resection of pulmonary metastases from sarcoma: can some patients benefit from a less invasive approach? Ann Thorac Surg 87:238–243

    Article  PubMed  Google Scholar 

  43. Cardona K, Williams R, Movva S (2013) Multimodality therapy for advanced or metastatic sarcoma. Curr Probl Cancer 37:74–86

    Article  PubMed  Google Scholar 

  44. Kim S, Ott HC, Wright CD et al (2011) Pulmonary resection of metastatic sarcoma: prognostic factors associated with improved outcomes. Ann Thorac Surg 92:1780–1787

    Article  PubMed  Google Scholar 

  45. Weiser MR, Downey RJ, Leung DH et al (2000) Repeat resection of pulmonary metastases in patients with soft-tissue sarcoma. J Am Coll Surg 191(2):184–190

    Article  CAS  PubMed  Google Scholar 

  46. Pastorino U, Buyse M, Friedel G et al (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113:37–49

    Article  CAS  PubMed  Google Scholar 

  47. van Geel AN, Pastorino U, Jauch KW et al (1996) Surgical treatment of lung metastases: the European organization for research and treatment of cancer-soft tissue and bone sarcoma group study of 255 patients. Cancer 77:675–682

    Article  PubMed  Google Scholar 

  48. Rehders A, Hosch SB, Scheunemann P, Stoecklein NH, Knoefel WT, Peiper M (2007) Benefit of surgical treatment of lung metastasis in soft tissue sarcoma. Arch Surg 142:70–75

    Article  PubMed  Google Scholar 

  49. Smith R, Pak Y, Kraybill W, Kane JM III (2009) Factors associated with actual long-term survival following soft tissue sarcoma pulmonary metastasectomy. Eur J Surg Oncol 35:356–361

    Article  CAS  PubMed  Google Scholar 

  50. Blackmon SH, Shah N, Roth JA, Correa AM, Vaporciyan AA, Rice DC et al (2009) Resection of pulmonary and extrapulmonary sarcomatous metastases is associated with long-term survival. Ann Thorac Surg 88:877–884

    Article  PubMed  Google Scholar 

  51. Lin AY, Kotova S, Yanagawa J, Elbuluk O, Wang G, Kar N et al (2015) Risk stratification of patients undergoing pulmonary metastasectomy for soft tissue and bone sarcomas. J Thorac Cardiovasc Surg 149:85–92

    Article  PubMed  Google Scholar 

  52. Smith R, Demmy TL (2012) Pulmonary metastasectomy for soft tissue sarcoma. Surg Oncol Clin N Am 21:269–286

    Article  PubMed  Google Scholar 

  53. McCormack PM, Ginsberg KB, Bains MS, Burt ME, Martini N, Rusch VW et al (1993) Accuracy of lung imaging in metastases with implications for the role of thoracoscopy. Ann Thorac Surg 56:863–865

    Article  CAS  PubMed  Google Scholar 

  54. Chudgar NP, Brennan MF, Munhoz RR, Bucciarelli PR, Tan KS, D’Angelo SP, Bains MS, Bott M, Huang J, Park BJ, Rusch VW, Adusumilli PS, Tap WD, Singer S, Jones DR (2017) Pulmonary metastasectomy with therapeutic intent for soft-tissue sarcoma. J Thorac Cardiovasc Surg 154(1):319–330.e1

    Article  PubMed  PubMed Central  Google Scholar 

  55. Ferguson PC, Deheshi BM, Chung P, Catton CN, O’Sullivan B, Gupta A, Griffin AM, Wunder JS (2011) Soft tissue sarcoma presenting with metastatic disease: outcome with primary surgical resection. Cancer 117(2):372–379

    Article  PubMed  Google Scholar 

  56. Keung EZ, Fairweather M, Raut CP (2016) Surgical management of metastatic disease. Surg Clin North Am 96(5):1175–1192

    Article  PubMed  Google Scholar 

  57. Yedibela S, Gohl J, Graz V et al (2005) Changes in indication and results after resection of hepatic metastases from noncolorectal primary tumors: a single-institutional review. Ann Surg Oncol 12:778–785

    Article  PubMed  Google Scholar 

  58. Lang H, Nussbaum KT, Kaudel P et al (2000) Hepatic metastases from leiomyosarcoma a single-center experience with 34 liver resections during a 15-year period. Ann Surg 231(4):500–505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Rosenberg SA, Tepper J, Glatstein E, Costa J, Baker A, Brennan M, DeMoss EV, Seipp C, Sindelar WF, Sugarbaker P, Wesley R (1982) The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196(3):305–315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Williard WC, Hajdu SI, Casper ES, Brennan MF (1992) Comparison of amputation with limb-sparing operations for adult soft tissue sarcoma of the extremity. Ann Surg 215(3):269–275

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. LeVay J, O’Sullivan B, Catton C, Bell R, Fornasier V, Cummings B, Hao Y, Warr D, Quirt I (1993) Outcome and prognostic factors in soft tissue sarcoma in the adult. Int J Radiat Oncol Biol Phys 27(5):1091–1099

    Article  CAS  PubMed  Google Scholar 

  62. Manoso MW, Frassica DA, Deune EG, Frassica FJ (2005) Outcomes of re-excision after unplanned excisions of soft-tissue sarcomas. J Surg Oncol 91(3):153–158

    Article  PubMed  Google Scholar 

  63. McNeer GP, Cantin J, Chu F, Nickson JJ (1968) Effectiveness of radiation therapy in the management of sarcoma of the soft somatic tissues. Cancer 22(2):391–397

    Article  CAS  PubMed  Google Scholar 

  64. Canter RJ, Beal S, Borys D, Martinez SR, Bold RJ, Robbins AS (2010) Interaction of histologic subtype and histologic grade in predicting survival for soft-tissue sarcomas. J Am Coll Surg 210(2):191–198.e2

    Article  PubMed  Google Scholar 

  65. Kuklo TR, Temple HT, Owens BD, Juliano J, Islinger RB, Andejeski Y, Frassica DA, Berrey BH (2005) Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. Am J Orthop (Belle Mead NJ) 34(2):75–80

    Google Scholar 

  66. Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, Ghert M (2010) A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma. Ann Surg Oncol 17(5):1367–1374

    Article  PubMed  Google Scholar 

  67. Sampath S, Schultheiss TE, Hitchcock YJ, Randall RL, Shrieve DC, Wong JY (2011) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma: multi-institutional analysis of 821 patients. Int J Radiat Oncol Biol Phys 81(2):498–505

    Article  PubMed  Google Scholar 

  68. Sarcoma Meta-Analysis Collaboration (1997) Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma meta-analysis collaboration. Lancet 350(9092):1647–1654

    Google Scholar 

  69. Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M (2008) A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer 113(3):573–581

    Article  PubMed  Google Scholar 

  70. Frustaci S, Gherlinzoni F, De Paoli A, Bonetti M, Azzarelli A, Comandone A, Olmi P, Buonadonna A, Pignatti G, Barbieri E, Apice G, Zmerly H, Serraino D, Picci P (2001) Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial. J Clin Oncol 19(5):1238–1247

    Article  CAS  PubMed  Google Scholar 

  71. Woll PJ, Reichardt P, Le Cesne A, Bonvalot S, Azzarelli A, Hoekstra HJ, Leahy M, Van Coevorden F, Verweij J, Hogendoorn PC, Ouali M, Marreaud S, Bramwell VH, Hohenberger P (2012) EORTC soft tissue and bone sarcoma group and the NCIC Clinical trials group sarcoma disease site committee. Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial. Lancet Oncol 13(10):1045–1054

    Article  CAS  PubMed  Google Scholar 

  72. Ferrari A, Gronchi A, Casanova M, Meazza C, Gandola L, Collini P, Lozza L, Bertulli R, Olmi P, Casali PG (2004) Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer 101(3):627–634

    Article  PubMed  Google Scholar 

  73. Cormier JN, Huang X, Xing Y, Thall PF, Wang X, Benjamin RS, Pollock RE, Antonescu CR, Maki RG, Brennan MF, Pisters PW (2004) Cohort analysis of patients with localized, high-risk, extremity soft tissue sarcoma treated at two cancer centers: chemotherapy-associated outcomes. J Clin Oncol 22(22):4567–4574

    Article  PubMed  Google Scholar 

  74. Eilber FC, Eilber FR, Eckardt J, Rosen G, Riedel E, Maki RG, Brennan MF, Singer S (2004) The impact of chemotherapy on the survival of patients with high-grade primary extremity liposarcoma. Ann Surg 240(4):686–695. discussion 695–7

    PubMed  PubMed Central  Google Scholar 

  75. Gronchi A, Frustaci S, Mercuri M, Martin J, Lopez-Pousa A, Verderio P, Mariani L, Valagussa P, Miceli R, Stacchiotti S, Dei Tos AP, De Paoli A, Longhi A, Poveda A, Quagliuolo V, Comandone A, Casali PG, Picci P (2012) Short, full-dose adjuvant chemotherapy in high-risk adult soft tissue sarcomas: a randomized clinical trial from the Italian sarcoma group and the Spanish sarcoma group. J Clin Oncol 30(8):850–856

    Article  CAS  PubMed  Google Scholar 

  76. Meric F, Milas M, Hunt KK, Hess KR, Pisters PW, Hildebrandt G, Patel SR, Benjamin RS, Plager C, Papadopolous NE, Burgess MA, Pollock RE, Feig BW (2000) Impact of neoadjuvant chemotherapy on postoperative morbidity in soft tissue sarcomas. J Clin Oncol 18(19):3378–3383

    Article  CAS  PubMed  Google Scholar 

  77. Gronchi A, Ferrari S, Quagliuolo V, Broto JM, Pousa AL, Grignani G, Basso U, Blay JY, Tendero O, Beveridge RD, Ferraresi V, Lugowska I, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Palmerini E, De Sanctis R, Morosi C, Stacchiotti S, Bagué S, Coindre JM, Dei Tos AP, Picci P, Bruzzi P, Casali PG (2017) Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial. Lancet Oncol 18(6):812–822

    Article  CAS  PubMed  Google Scholar 

  78. Schuetze SM, Rubin BP, Vernon C, Hawkins DS, Bruckner JD, Conrad EU 3rd, Eary JF (2005) Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy. Cancer 103(2):339–348

    Article  PubMed  Google Scholar 

  79. Catton C, Davis A, Bell R, O’Sullivan B, Fornasier V, Wunder J, McLean M (1996c) Soft tissue sarcoma of the extremity. Limb salvage after failure of combined conservative therapy. Radiother Oncol 41(3):209–214

    Article  CAS  PubMed  Google Scholar 

  80. Karakousis CP, Proimakis C, Rao U, Velez AF, Driscoll DL (1996) Local recurrence and survival in soft-tissue sarcomas. Ann Surg Oncol 3(3):255–260

    Article  CAS  PubMed  Google Scholar 

  81. Ueda T, Yoshikawa H, Mori S, Araki N, Myoui A, Kuratsu S, Uchida A (1997) Influence of local recurrence on the prognosis of soft-tissue sarcomas. J Bone Joint Surg Br 79(4):553–557

    Article  CAS  PubMed  Google Scholar 

  82. Van Glabbeke M, van Oosterom AT, Oosterhuis JW, Mouridsen H, Crowther D, Somers R, Verweij J, Santoro A, Buesa J, Tursz T (1999) Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens – a European organization for research and treatment of cancer soft tissue and bone sarcoma group study. J Clin Oncol 17(1):150–157

    Article  PubMed  Google Scholar 

  83. Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöffski P, Blay JY, Kerst JM, Sufliarsky J, Whelan J, Hohenberger P, Krarup-Hansen A, Alcindor T, Marreaud S, Litière S, Hermans C, Fisher C, Hogendoorn PC, dei Tos AP, van der Graaf WT, European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (2014) Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncol 15(4):415–423

    Article  CAS  PubMed  Google Scholar 

  84. Chawla SP, Papai Z, Mukhametshina G, Sankhala K, Vasylyev L, Fedenko A, Khamly K, Ganjoo K, Nagarkar R, Wieland S, Levitt DJ (2015) First-line aldoxorubicin vs doxorubicin in metastatic or locally advanced unresectable soft-tissue sarcoma: a phase 2b randomized clinical trial. JAMA Oncol 1(9):1272–1280

    Article  PubMed  Google Scholar 

  85. van der Graaf WT, Blay JY, Chawla SP, Kim DW, Bui-Nguyen B, Casali PG, Schöffski P, Aglietta M, Staddon AP, Beppu Y, Le Cesne A, Gelderblom H, Judson IR, Araki N, Ouali M, Marreaud S, Hodge R, Dewji MR, Coens C, Demetri GD, Fletcher CD, Dei Tos AP (2012) Hohenberger P; EORTC soft tissue and bone sarcoma group; PALETTE study group. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 379(9829):1879–1886

    Article  CAS  PubMed  Google Scholar 

  86. Verschoor AJ, Gelderblom H (2014) Pneumothorax as adverse event in patients with lung metastases of soft tissue sarcoma treated with pazopanib: a single reference centre case series. Clin Sarcoma Res 1(4):14

    Article  Google Scholar 

  87. Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D’Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR (2016) Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet 387(10028):1629–1637

    Article  CAS  PubMed  Google Scholar 

  88. Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR (2016) Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: results of a phase III randomized multicenter clinical trial. J Clin Oncol 34(8):786–793

    Article  CAS  PubMed  Google Scholar 

  89. D’Angelo SP, Mahoney MR, Van Tine BA, Atkins J, Milhem MM, Jahagirdar BN, Antonescu CR, Horvath E, Tap WD, Schwartz GK, Streicher H (2018) Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Lancet Oncol 19(3):416–426

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Division of Sarcoma, Ceará Cancer Institute, Fortaleza, CE, Brazil

    Carlos Márcio Melo de Matos, Irapuan Teles de Araújo Filho, Marcos Vieira Fernandes, Dárcio Jânio Macedo Barbosa & Afrânio Tavares André

  2. Mount Vernon Cancer Centre, London, UK

    Geourgius Antoniou

  3. Division of Medical Oncology, Federal University of São Paulo (UNIFESP) & Hospital Israelita Albert Einstein, São Paulo, Brazil

    Ramon Andrade De Mello

  4. Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

    Ramon Andrade De Mello

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  7. Ramon Andrade De Mello
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Correspondence to Ramon Andrade De Mello .

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Editors and Affiliations

  1. Division of Medical Oncology, Federal University of São Paulo (UNIFESP) & Hospital Israelita Albert Einstein, São Paulo, Brazil, Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

    Ramon Andrade De Mello

  2. Oncology Department, Henry Dunant Hospital Center, Athens, Greece

    Giannis Mountzios

  3. Department of Biomedical Sciences and Medicine, Universidade do Algarve, Faro, Portugal

    Álvaro A. Tavares

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de Matos, C.M.M. et al. (2019). Soft Tissue Sarcomas. In: De Mello, R., Mountzios, G., Tavares, Á. (eds) International Manual of Oncology Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-16245-0_35

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