Abstract
Since subarachnoid hemorrhage is a devastating condition with high mortality and poor outcome, an appropriate animal model for research is needed. Although the monofilament perforation model in rats is a challenging procedure to learn, the induction of subarachnoid hemorrhage in this way is by far the most suited model for investigating the pathophysiological mechanisms of subarachnoid hemorrhage. Additionally, this surgical technique shares similarities with stroke models. The following chapter offers a step-by-step manual of how to induce subarachnoid hemorrhage in rats with ease.
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Ho, W.M., Reis, C., Akyol, O., Cahill, J., McBride, D., Zhang, J.H. (2019). Monofilament Perforation Subarachnoid Hemorrhage Rat Model. In: Chen, J., Xu, Z., Xu, X., Zhang, J. (eds) Animal Models of Acute Neurological Injury. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16082-1_15
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DOI: https://doi.org/10.1007/978-3-030-16082-1_15
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