Curious2018 pp 87-94 | Cite as

Out of Curiosity from Blue Sky Research to Medical Innovation

  • Rudi BallingEmail author


Curiosity, the intrinsic urge to know and to find out more about whatever has caught our mind, seems to be laid down in our DNA. Much has been written about the evolution and the forces that drove human evolution. We cannot repeat the experiment, but try to imagine human mankind without the trait called “Curiosity”? This trait seems to be closely associated with genes related to the dopamine and the dopamine receptor system, which in turn we know is connected to personality traits such as novelty-seeking, exploration behavior, risk-taking, or reward-expectancy and, on a more darker side, addiction.


  1. 1.
    Arnold FH. Directed evolution: bringing new chemistry to life. Angew Chem Int Ed. 2018;57:4143–8. Scholar
  2. 2.
    Beutler B. Innate immunity and the new forward genetics. Best Pract Res Clin Haematol. 2016;29:379–87. Scholar
  3. 3.
    Chen F, Ma K, Madajewski B, Zhuang L, Zhang L, Rickert K, Marelli M, Yoo B, Turker MZ, Overholtzer M, Quinn TP, Gonen M, Zanzonico P, Tuesca A, Bowen MA, Norton L, Subramony A, Wiesner U, Bradbury MS. Ultrasmall targeted nanoparticles with engineered fragments for imaging detection of HER2-overexpressing breast cancer. Nat Comm 2018;9:4141.
  4. 4.
    Collins BSL, Wilson CM, Myers EL, Aggarwal VK. Asymmetric synthesis of secondary and tertiary boronic esters. Angew Chem Int Ed. 2017;56:11700–33. Scholar
  5. 5.
    Stoddart JF. Mechanically interlocked molecules (MIMs)-molecular shuttles, switches and machines (Nobel Lecture). Angew Chem Int Ed Engl. 2018;56(37):11094–125. Scholar
  6. 6.
    Duckworth AD, Gherardini PF, Sykorova M, Yasin F, Nolan GP, Slupsky JR, Kalakonda N. Miltioplexed profiling of RNA and protein expression signatures in individual cells using flow or mass cytometry. Nat Protoc 2019. Scholar
  7. 7.
    Frank J, Ourmazd A. Continuous changes in structure mapped by manifold embedding of single-particle data in Cryo-EM. Methods. 2016;100:61–7. Scholar
  8. 8.
    Gavara N. A beginners guide to atomic force microscopy probing for cell mechanics. Microsc Res Tech 2017; 80:75–84. Scholar
  9. 9.
    Goodfellow I, Bengio Y, Courville A. Deep Learning. Cambridge, MA; The MIT Press; 2016, ISBN 9780262035613.Google Scholar
  10. 10.
    Gruber MJ, Gelman BD, Ranganath C. States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit. Neuron. 2014;84:486–96. Scholar
  11. 11.
    Hille F, Richter H, Wong SP, Bratovic M, Ressel S, Charpentier E. The biology of CRISPR-CAS: backward and forward. Cell. 2017;172:1239–59. Scholar
  12. 12.
    Hoshino M, Khutia A, Xing H, Inokuma Y, Fujita M. The crystalline sponge method updated. IUCrJ. 2016;3:139–51. Scholar
  13. 13.
    Hoyles L, Fernandez-Real JM, Federici M, Serino M, Abbot J, Charpentier J, Heymes C, Latorre LJ, Anthony E, Barton RH, Chilloux J, Myridakis A, Martinez-Gili L, Maria Moreno-Nasvarette J, Benhamed F, Azalbert V, Blasco-Bacque V, Puig J, Xifra G, Ricart W, Tomlinson C, Woodbridge M, Cardellini M, Devato F, Cardolini I, Porzio O, Gentileschi P, Loez F, Foufelle F, Butcher SA, Holmes E, Nicholson JK, Bureelin R, Dumas ME. Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat Med. 2018;24:1070–80. Scholar
  14. 14.
    Mahlau M, List B. Asymmetric counteranion-directed catalysis: concept, definition and applications. Angew Che Int Ed. 2013;52:518–33. Scholar
  15. 15.
    Brown CE, Mackall CL. CAR T cell therapy: inroads to response and resistance. Nat Rev. 2019;19:73–4.Google Scholar
  16. 16.
    Reid JE, Wernisch L. Pseudotime estimation: deconfounding single cell time series. Bioinformatis. 2016;32:2973–80. Scholar
  17. 17.
    Richardson SM, Mitchell LA, Stracquadanio G, Yang KY, Dymond JS, DiCarlo JE, Lee D, Huang CLV, Chandrasegaran S, Xai Y, Boeke JD, Bader JS. Design of a synthetic yeast genome. Science. 2017;355:1040–4.CrossRefGoogle Scholar
  18. 18.
    Schrödinger E. What is life? The physical aspect of the living cell. Cambridge: Cambridge University Press; 1944. ISBN 0-521-42708-8.Google Scholar
  19. 19.
    Schumpeter, Joseph A. Capitalism, Socialism, and Democracy. 3d ed. New York: Harper and Brothers; 1942 (1950).Google Scholar
  20. 20.
    Telenti A, Pierce LCT, Biggs WH, Di Jiulio J, Wong EHM, Fabani MH, Kirkness WF, Moustafa A, Shah N, Brewerton SC, Bulsara N, Garner C, Metzker G, Sandoval E, Perkins bA, Och FH, Turzpaz Y, Venter JC. Deep sequencing of 10,000 human genomes PNAS 2016; 113:11901–11906.
  21. 21.
    Topol E. The creative destruction of medicine. How the digital revolution will create better health care. New York: Basic Books; 2012.Google Scholar
  22. 22.
    Yanagisawa Y, Nan Y, Okuro K, Aida T. Mechanically robust, readily repairable polymers via tailored nonovalent crosss-linking. Science. 2018;359:72–6. Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Luxembourg Centre for Systems Biomedicine (LCSB)University of LuxembourgBelvauxLuxembourg
  2. 2.Scripps Translational Science InstituteLa JollaUSA

Personalised recommendations