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Protein Biomarkers in Major Depressive Disorder: An Update

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Advancements of Mass Spectrometry in Biomedical Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1140))

Abstract

Major depressive disorder (MDD) is common. Despite numerous available treatments, many individuals fail to improve clinically. Diagnosis of MDD continues to be commonly accomplished via behavioral rather than biological methods. Biomarkers may provide objective diagnosis of MDD, and could include measurements of genes, proteins, and patterns of brain activity. Proteomic analysis and validation of biomarkers is less explored than other areas of biomarker research in MDD. Mass spectrometry (MS) is a comprehensive, unbiased means of proteomic analysis, which can be complemented by directed protein measurements, such as Western Blotting. Prior studies have focused on MS analysis of several human biomaterials in MDD, including human post-mortem brain, cerebrospinal fluid (CSF), blood components, and urine. Further studies utilizing MS and proteomic analysis in MDD may help solidify and establish biomarkers for use in diagnosis, identification of new treatment targets, and understanding of the disorder. A biomarker or a biomarker signature that facilitates a convenient and inexpensive predictive test for depression treatment response is highly desirable.

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Acknowledgments

We thank past and current members of the Biochemistry & Proteomics Group for the nice work environment and fruitful discussions.

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Author notes

  1. Dan V. Iosifescu

    Present address: Nathan S. Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY, USA

  2. Alisa G. Woods and Kelly L. Wormwood contributed equally to this work.

Authors and Affiliations

  1. Biochemistry & Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA

    Alisa G. Woods, Kelly L. Wormwood & Costel C. Darie

  2. Mood and Anxiety Disorders Program, Mount Sinai School of Medicine, New York, NY, USA

    Dan V. Iosifescu & James Murrough

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  1. Alisa G. Woods
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  2. Kelly L. Wormwood
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  4. James Murrough
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  5. Costel C. Darie
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Correspondence to Alisa G. Woods .

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Editors and Affiliations

  1. Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA

    Alisa G. Woods

  2. Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA

    Costel C. Darie

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Woods, A.G., Wormwood, K.L., Iosifescu, D.V., Murrough, J., Darie, C.C. (2019). Protein Biomarkers in Major Depressive Disorder: An Update. In: Woods, A., Darie, C. (eds) Advancements of Mass Spectrometry in Biomedical Research. Advances in Experimental Medicine and Biology, vol 1140. Springer, Cham. https://doi.org/10.1007/978-3-030-15950-4_35

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