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Asymptomatic HyperCKemia

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Managing Myositis

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Abstract

Serum creatine kinase (CK) concentrations have been widely used as the primary muscle enzyme marker for diagnosis and follow-up of inflammatory myopathy and other muscle diseases. Asymptomatic hyperCKemia is a diagnostic dilemma and is defined as the persistent elevation of the serum CK with no or minimal muscle-related signs and symptoms such as myalgia and/or weakness. Some patients with asymptomatic hyperCKemia may experience minimal non-specific muscle symptoms such as muscle spasms, cramps, and fatigue that do not interfere significantly with activities of daily living. Asymptomatic hyperCKemia can occur in the setting of neuromuscular or non-neuromuscular etiologies. Neuromuscular etiologies include diseases such as muscular dystrophy and metabolic myopathy, whereas non-neuromuscular etiologies refer to other diseases with neuromuscular symptoms such as endocrine disorders, metabolic disturbances, or muscle trauma.

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  1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Siamak Moghadam-Kia & Rohit Aggarwal

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  1. Siamak Moghadam-Kia
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Correspondence to Rohit Aggarwal .

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  1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA

    Rohit Aggarwal

  2. Division of Rheumatology and Clinical Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA

    Chester V. Oddis

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Moghadam-Kia, S., Aggarwal, R. (2020). Asymptomatic HyperCKemia. In: Aggarwal, R., Oddis, C. (eds) Managing Myositis. Springer, Cham. https://doi.org/10.1007/978-3-030-15820-0_4

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