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Prevention of Bacterial, Viral, Fungal, and Parasitic Infections During the Early Post-transplant Period

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Infectious Diseases in Solid-Organ Transplant Recipients

Abstract

Traditionally, the early post-solid-organ-transplant (SOT) period is defined as the first 6 months after SOT. Nosocomial infections predominate during the first month, linked with (1) the pre-transplant conditions of both recipient and donor, (2) the surgical act of transplant, and (3) the general infectious risk of intensive care patients due to indwelling catheters and intubation devices (Fishman, N Engl J Med 357:2601–2614, 2007). Thereafter, infections with opportunistic pathogens and reactivation of latent pathogens are the major concerns. These risks vary according to the type of transplant, prior exposures, and local epidemiology. Accordingly, preventive strategies must be adapted to both individual and local conditions. In this chapter, we will discuss a global approach to the most common early post-SOT infections and how to optimize their prevention.

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References

  1. Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357(25):2601–14.

    Article  CAS  Google Scholar 

  2. Mularoni A, Bertani A, Vizzini G, et al. Outcome of transplantation using organs from donors infected or colonized with carbapenem-resistant gram-negative bacteria. Am J Transplant. 2015;15(10):2674–82.

    Article  CAS  Google Scholar 

  3. Aguado JM, Silva JT, Fernandez-Ruiz M, et al. Management of multidrug resistant gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations. Transplant Rev. 2018;32(1):36–57.

    Article  CAS  Google Scholar 

  4. Cervera C, van Delden C, Gavalda J, et al. Multidrug-resistant bacteria in solid organ transplant recipients. Clin Microbiol Infect. 2014;20(Suppl 7):49–73.

    Article  Google Scholar 

  5. van Duin D, van Delden C, Practice ASTIDCo. Multidrug-resistant gram-negative bacteria infections in solid organ transplantation. Am J Transplant. 2013;13(Suppl 4):31–41.

    Article  Google Scholar 

  6. Beaume M, Kohler T, Greub G, et al. Rapid adaptation drives invasion of airway donor microbiota by Pseudomonas after lung transplantation. Sci Rep. 2017;7:40309.

    Article  CAS  Google Scholar 

  7. Smibert O, Snell GI, Bills H, Westall GP, Morrissey CO. Mycobacterium abscessus complex – a particular challenge in the setting of lung transplantation. Expert Rev Anti-Infect Ther. 2016;14(3):325–33.

    Article  CAS  Google Scholar 

  8. Seem DL, Lee I, Umscheid CA, Kuehnert MJ, United States Public Health S. PHS guideline for reducing human immunodeficiency virus, hepatitis B virus, and hepatitis C virus transmission through organ transplantation. Public Health Rep. 2013;128(4):247–343.

    Article  Google Scholar 

  9. Kotton CN, Kumar D, Caliendo AM, et al. The third international consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation. 2018;102(6):900–31.

    Article  Google Scholar 

  10. Rubin LG, Levin MJ, Ljungman P, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58(3):e44–e100.

    Article  Google Scholar 

  11. Peters AC, Akinwumi MS, Cervera C, et al. The changing epidemiology of posttransplant lymphoproliferative disorder in adult solid organ transplant recipients over 30 years: a single center experience. Transplantation. 2018;102(9):1553–62.

    Article  Google Scholar 

  12. Huprikar S, Danziger-Isakov L, Ahn J, et al. Solid organ transplantation from hepatitis B virus-positive donors: consensus guidelines for recipient management. Am J Transplant. 2015;15(5):1162–72.

    Article  CAS  Google Scholar 

  13. Levitsky J, Formica RN, Bloom RD, et al. The American Society of Transplantation consensus conference on the use of hepatitis C viremic donors in solid organ transplantation. Am J Transplant. 2017;17(11):2790–802.

    Article  CAS  Google Scholar 

  14. Durand CM, Bowring MG, Brown DM, et al. Direct-acting antiviral prophylaxis in kidney transplantation from hepatitis C virus-infected donors to noninfected recipients: an open-label nonrandomized trial. Ann Intern Med. 2018;168(8):533–40.

    Article  Google Scholar 

  15. Hirsch HH, Randhawa P, Practice ASTIDCo. BK polyomavirus in solid organ transplantation. Am J Transplant. 2013;13(Suppl 4):179–88.

    Article  CAS  Google Scholar 

  16. Hirsch HH, Babel N, Comoli P, et al. European perspective on human polyomavirus infection, replication and disease in solid organ transplantation. Clin Microbiol Infect. 2014;20(Suppl 7):74–88.

    Article  Google Scholar 

  17. Hogen R, Dhanireddy KK. Invasive fungal infections following liver transplantation. Curr Opin Organ Transplant. 2017;22(4):356–63.

    Article  Google Scholar 

  18. Hamandi B, Fegbeutel C, Silveira FP, et al. Voriconazole and squamous cell carcinoma after lung transplantation: a multicenter study. Am J Transplant. 2018;18(1):113–24.

    Article  CAS  Google Scholar 

  19. Robert-Gangneux F, Meroni V, Dupont D, et al. Toxoplasmosis in transplant recipients, Europe, 2010–2014. Emerg Infect Dis. 2018;24(8):1497–504.

    Article  CAS  Google Scholar 

  20. Roxby AC, Gottlieb GS, Limaye AP. Strongyloidiasis in transplant patients. Clin Infect Dis. 2009;49(9):1411–23.

    Article  Google Scholar 

  21. Abanyie FA, Gray EB, Delli Carpini KW, et al. Donor-derived Strongyloides stercoralis infection in solid organ transplant recipients in the United States, 2009–2013. Am J Transplant. 2015;15(5):1369–75.

    Article  CAS  Google Scholar 

  22. Chin-Hong PV, Schwartz BS, Bern C, et al. Screening and treatment of chagas disease in organ transplant recipients in the United States: recommendations from the chagas in transplant working group. Am J Transplant. 2011;11(4):672–80.

    Article  CAS  Google Scholar 

  23. Asberg A, Humar A, Rollag H, et al. Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant. 2007;7(9):2106–13.

    Article  CAS  Google Scholar 

  24. Len O, Gavalda J, Aguado JM, et al. Valganciclovir as treatment for cytomegalovirus disease in solid organ transplant recipients. Clin Infect Dis. 2008;46(1):20–7.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Camille Nelson Kotton

  2. Transplant Infectious Diseases Unit, University Hospitals Geneva, Geneva, Switzerland

    Christian van Delden

Authors
  1. Camille Nelson Kotton
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  2. Christian van Delden
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Corresponding author

Correspondence to Camille Nelson Kotton .

Editor information

Editors and Affiliations

  1. Infectious Diseases Service and Transplantation Center, University Hospital of Lausanne, Lausanne, Switzerland

    Oriol Manuel

  2. School of Medicine, Northwestern University Feinberg, Chicago, IL, USA

    Michael G Ison

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Kotton, C.N., van Delden, C. (2019). Prevention of Bacterial, Viral, Fungal, and Parasitic Infections During the Early Post-transplant Period. In: Manuel, O., Ison, M. (eds) Infectious Diseases in Solid-Organ Transplant Recipients. Springer, Cham. https://doi.org/10.1007/978-3-030-15394-6_4

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  • DOI: https://doi.org/10.1007/978-3-030-15394-6_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-15393-9

  • Online ISBN: 978-3-030-15394-6

  • eBook Packages: MedicineMedicine (R0)

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