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Abstract

Acute lung injury is a term that may be used to include patients with rapidly progressive respiratory failure and diffuse lung infiltrates. A variety of causes or clinical settings may be linked to this context. CT scan features and laboratory tests are helpful to significantly shorten the differential diagnostic list. Bronchoalveolar lavage (BAL) has an important diagnostic role because some causative agents may be identified by this approach, and also the cytological profile may greatly contribute to the definite diagnosis. In only a minority of patients, biopsy remains useful for planning treatment strategies. Whereas anecdotic reports and a few short series already addressed the role of regular transbronchial lung biopsy and surgical lung biopsy, the role of transbronchial cryobiopsy remains to be elucidated.

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References

  1. Katzenstein AL. Acute lung injury pa Fourth Edtterns: diffuse alveolar damage and bronchiolitis obliterans-organizing pneumonia. In: Katzenstein AL, editor. Katzenstein and Askin’s non-neoplastic lung disease. 4th ed. Philadelphia: Saunders Elsevier; 2006. p. 17–49.

    Google Scholar 

  2. Dalpiaz G, Cancellieri A. Alveolar pattern. In: Dalpiaz G, Cancellieri A, editors. Atlas of diffuse lung disease. Cham: Springer; 2017. p. 145–201.

    Chapter  Google Scholar 

  3. Linssen KC, Jacobs JA, Poletti V, van Mook W, Cornelissen EI, Drent M. Reactive type II pneumocytes in bronchoalveolar lavage fluid. Acta Cytol. 2004;48:497–504.

    Article  Google Scholar 

  4. Cazzato S, Zompatori M, Baruzzi G, et al. Bronchiolitis obliterans-organizing pneumonia: an Italian experience. Respir Med. 2000;94:702–8.

    Article  CAS  Google Scholar 

  5. Nishino M, Mathai SK, Schoenfeld D, Digumarthy SR, Kradin RL. Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. Hum Pathol. 2014;45:342–51.

    Article  Google Scholar 

  6. Torrealba JR, Fisher S, Kanne JP, et al. Pathology-radiology correlation of common and uncommon computed tomographic patterns of organizing pneumonia. Hum Pathol. 2018;71:30–40.

    Article  Google Scholar 

  7. Ravaglia C, Gurioli C, Casoni G, Romagnoli M, Tomassetti S, Gurioli C, Corso RM, Poletti G, Dubini A, Marinou A, Poletti V. Diagnostic role of rapid on-site cytologic examination (ROSE) of broncho-alveolar lavage in ALI/ARDS. Pathologica. 2012;104:65–9.

    CAS  PubMed  Google Scholar 

  8. Poletti V, Poletti G, Murer B, Saragoni L, Chilosi M. Bronchoalveolar lavage in malignancy. Semin Respir Crit Care Med. 2007;28:534–45.

    Article  Google Scholar 

  9. Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment. JAMA. 2018;319:698–710.

    Article  Google Scholar 

  10. Park J, Lee YJ, Lee J, et al. Histopathologic heterogeneity of acute respiratory distress syndrome revealed by surgical lung biopsy and its clinical implications. Korean J Intern Med. 2018;33:532–40.

    Article  Google Scholar 

  11. Pillipponet C, Cassagnes L, Pereira B, et al. Diagnostic yield and therapeutic impact of open lung biopsy in the critically ill patient. PLoS One. 2018;13:e0196795.

    Article  Google Scholar 

  12. Bulpa PA, Dive AM, Mertens L, et al. Combined bronchoalveolar lavage and transbronchial lung biopsy: safety and yield in ventilated patients. Eur Respir J. 2003;21:489–94.

    Article  CAS  Google Scholar 

  13. Dincer HE, Zamora F, Gibson H, Cho RJ. The first report of safety and feasibility of transbronchial cryoprobe lung biopsy in ARDS. Intensive Care Med. 2018;44:971–2.

    Article  Google Scholar 

  14. Poletti V, Casoni GL, Cancellieri A, Piciucchi S, Dubini A, Zompatori M. Diffuse alveolar damage. Pathologica. 2010;102:453–63.

    CAS  PubMed  Google Scholar 

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Poletti, V., Poletti, G., Gurioli, C., Gurioli, C., Dubini, A. (2019). Acute Lung Injury. In: Poletti, V. (eds) Transbronchial cryobiopsy in diffuse parenchymal lung disease. Springer, Cham. https://doi.org/10.1007/978-3-030-14891-1_16

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  • DOI: https://doi.org/10.1007/978-3-030-14891-1_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-14890-4

  • Online ISBN: 978-3-030-14891-1

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