Skip to main content
SpringerLink
Log in

Clinical Meaning of Transbronchial Cryobiopsy

  • Chapter
  • First Online:
Book cover Transbronchial cryobiopsy in diffuse parenchymal lung disease

  • 341 Accesses

Abstract

Transbronchial cryobiopsy has been shown to provide samples large enough to identify also complex morphological patterns. Its diagnostic accuracy however is not yet well determined because there are not yet head-to-head studies comparing transbronchial cryobiopsy with what still now is considered the gold standard, surgical lung biopsy. However there are data documenting that this mini-invasive approach may increase significantly the diagnostic confidence in the setting of multidisciplinary discussion and may contribute to reach a final diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. King TE Jr, Bradford WZ, Castro-Bernardini S, et al. A phase 3 trial of pirfenidone in patient with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2083–92.

    Article  PubMed  Google Scholar 

  2. Richeldi L, du Bois RM, Raghu G, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2071–82.

    Article  PubMed  Google Scholar 

  3. ATS/ERS&JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183:788–824.

    Article  Google Scholar 

  4. Raghu G, Collard HR, Egan JJ, et al.; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183:788–824.

    Google Scholar 

  5. Poletti V, Ravaglia C, Gurioli C, et al. Invasive diagnostic techniques in idiopathic interstitial pneumonias. Respirology. 2016;21:44–50.

    Article  PubMed  Google Scholar 

  6. Hutchinson JP, Fogarty AW, McKeever TM, et al. In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011. Am J Respir Crit Care Med. 2016;193:1161–7.

    Article  CAS  PubMed  Google Scholar 

  7. Fibla JJ, Molins L, Blanco A, et al. Video-assisted thoracoscopic lung biopsy in the diagnosis of interstitial lung disease: a prospective, multicenter study in 224 patients. Arch Bronconeumol. 2012;48:81–5.

    Article  PubMed  Google Scholar 

  8. Kreider ME, Hansen-Flaschen J, Ahmad NN, Rossman MD, Kaiser LR, Kucharczuk JC, Shrager JB. Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease. Ann Thorac Surg. 2007;83:1140–4.

    Article  PubMed  Google Scholar 

  9. Sheth JS, Belperio JA, Fishbein MC, et al. Utility of transbronchial vs surgical lung biopsy in the diagnosis of suspected fibrotic interstitial lung disease. Chest. 2017;151:389–99.

    Article  PubMed  Google Scholar 

  10. Utz JP, Ryu JH, Douglas WW, et al. High short-term mortality following lung biopsy for usual interstitial pneumonia. Eur Respir J. 2001;17:175–9.

    Article  CAS  PubMed  Google Scholar 

  11. Park JH, Kim DK, Kim DS, et al. Mortality and risk factors for surgical lung biopsy in patients with idiopathic interstitial pneumonia. Eur J Cardiothorac Surg. 2007;31:1115–9.

    Article  PubMed  Google Scholar 

  12. Poletti V, Ravaglia C, Dubini A, et al. How might transbronchial cryobiopsy improve diagnosis and treatment of diffuse parenchymal lung disease patients? Expert Rev Respir Med. 2017;11:913–7.

    CAS  PubMed  Google Scholar 

  13. Cazzato S, Zompatori M, Burzi M, et al. Bronchoalveolar lavage and transbronchial lung biopsy in alveolar and/or ground glass opacification. Monaldi Arch Chest Dis. 1999;54:115–9.

    CAS  PubMed  Google Scholar 

  14. Leslie KO, Gruden JF, Parish JM, et al. Arch Pathol Lab Med. 2007;131:407–23.

    PubMed  Google Scholar 

  15. Colby TV. The pathologist’s approach to bronchoscopic biopsies. Pathologica. 2010;102:432–42.

    CAS  PubMed  Google Scholar 

  16. Griff S, Schönfeld N, Ammenwerth W, et al. Diagnostic yield of transbronchial cryobiopsy in non-neoplastic lung disease: a retrospective case series. BMC Pulm Med. 2014;14:171.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Poletti V, Ravaglia C, Tomassetti S. Transbronchial cryobiopsy in diffuse parenchymal lung diseases. Curr Opin Pulm Med. 2016;22:289–96.

    Article  PubMed  Google Scholar 

  18. Joyner LR, Scheinhorn DJ. Transbronchial forceps lung biopsy through the fiberoptic bronchoscope. Diagnosis of diffuse pulmonary disease. Chest. 1975;67:532–5.

    Article  CAS  PubMed  Google Scholar 

  19. Poletti V, Chilosi M, Olivieri D. Diagnostic invasive procedure in diffuse infiltrative lung disease. Respiration. 2004;71:107–19.

    Article  PubMed  Google Scholar 

  20. Tomassetti S, Cavazza A, Colby TV, et al. Transbronchial biopsy is useful in predicting UIP pattern. Respir Res. 2012;13:96.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Tomassetti S, Ravaglia C, Poletti V. Diffuse parenchymal lung disease. Eur Respir Rev. 2017;26:170004.

    Article  PubMed  Google Scholar 

  22. Hetzel J, Maldonado F, Ravaglia C, et al. Transbronchial cryobiopsies for the diagnosis of diffuse parenchymal lung diseases: expert statement from the cryobiopsy working group on safety and utility and a call for standardization of the procedure. Respiration. 2018;95:188–200.

    Article  PubMed  Google Scholar 

  23. Casoni GL, Tomassetti S, Cavazza A, et al. Transbronchial lung cryobiopsy in the diagnosis of fibrotic interstitial lung diseases. PLoS One. 2014;9:e86716.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Latsi PI, Du Bois RM, Nicholson AG, et al. Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. Am J Respir Crit Care Med. 2003;168:531–7.

    Article  PubMed  Google Scholar 

  25. Qiu M, Chen Y, Ye Q. Risk factors for acute exacerbation of idiopathic pulmonary fibrosis: a systematic review and meta-analysis. Clin Respir J. 2017;12:1084–92.

    Article  PubMed  Google Scholar 

  26. Fujimoto K, Taniguchi H, Johkoh T, et al. Acute exacerbation of idiopathic pulmonary fibrosis: high resolution CT scores predict mortality. Eur Radiol. 2012;22:83–92.

    Article  PubMed  Google Scholar 

  27. Ravaglia C, Bonifazi M, Wells AU, et al. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiration. 2016;91:215–27.

    Article  PubMed  Google Scholar 

  28. Iftikhar IH, Alghothani L, Sardi A, et al. Transbronchial lung cryobiopsy and video-assisted thoracoscopic lung biopsy in the diagnosis of diffuse parenchymal lung disease: a meta-analysis of diagnostic test accuracy. Ann Am Thorac Soc. 2017;14:1197–211.

    PubMed  Google Scholar 

  29. Bango-Alvarez A, Ariza-Prota M, Torres-Rivas H, et al. Transbronchial cryobiopsy in interstitial lung disease: experience in 106 cases—how to do it. ERJ Open Res. 2017;3:00148-2016.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Pajares V, Puzo C, Castillo D, et al. Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: a randomized trial. Respirology. 2014;19:900–6.

    Article  PubMed  Google Scholar 

  31. Schumann C, Hetzel J, Babiak AJ, et al. Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions. J Thorac Cardiovasc Surg. 2010;140:417–21.

    Article  PubMed  Google Scholar 

  32. Babiak A, Hetzel J, Krishna G, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration. 2009;78:203–8.

    Article  PubMed  Google Scholar 

  33. Griff S, Ammenwerth W, Schonfeld N, et al. Morphometrical analysis of transbronchial cryobiopsies. Diagn Pathol. 2011;6:53.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Poletti V, Hetzel J. Transbronchial cryobiopsy in diffuse parenchymal lung diseases: need of procedural standardization. Respiration. 2015;90:275–8.

    Article  PubMed  Google Scholar 

  35. Hagmeyer L, Theegarten D, Wohlschläger J, et al. The role of transbronchial cryobiopsy and surgical lung biopsy in the diagnostic algorithm of interstitial lung disease. Clin Respir J. 2015;10:589–95.

    Article  PubMed  Google Scholar 

  36. Ravaglia C, Wells AU, Tomassetti S, Gurioli C, Gurioli C, Dubini A, Cavazza A, Colby TV, Piciucchi S, Puglisi S, Bosi M, Poletti V. Diagnostic yield and risk/benefit analysis of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients. BMC Pulm Med. 2019;19:16.

    Google Scholar 

  37. Tomassetti S, Wells AU, Constabel U, et al. Bronchoscopic lung cryobiopsy increase diagnostic confidence in the multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Am J Resp Crit Care Med. 2016;193:745–52.

    Article  PubMed  Google Scholar 

  38. Poletti V, Casoni GL, Gurioli G, et al. Lung cryobiopsies: a paradigm shift in diagnostic bronchoscopy. Respirology. 2014;19:645–54.

    Article  PubMed  Google Scholar 

  39. Flaherty KR, Travis WD, Colby TV, et al. Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med. 2001;164:1722–7.

    Article  CAS  PubMed  Google Scholar 

  40. Flint A, Martinez FJ, Young ML, et al. Influence of sample and number and biopsy site on the histologic diagnosis of diffuse lung disease. Ann Thorac Surg. 1995;60:1605–8.

    Article  CAS  PubMed  Google Scholar 

  41. Winterbauer RH, Hammar SP, Hallman KO, et al. Diffuse interstitial pneumonitis. Clinicopathologic correlations in 20 patients treated with prednisone/azathioprine. Am J Med. 1978;65:661–72.

    Article  CAS  PubMed  Google Scholar 

  42. Cherniack RM, Colby TV, Flint A, et al. Quantitative assessment of lung pathology in idiopathic pulmonary fibrosis. The BAL Cooperative Group Steering Committee. Am Rev Respir Dis. 1991;144:892–900.

    Article  CAS  PubMed  Google Scholar 

  43. Kreuter M, Ehlers-Tenenbaum S, Palmowski K, et al. Impact of comorbidities on mortality in patients with idiopathic pulmonary fibrosis. PLoS One. 2016;11:e0151425.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Wuyts WA, Antoniou KM, et al. Combination therapy: the future of management for idiopathic pulmonary fibrosis? Lancet Respir Med. 2014;2:933–42.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diseases of the Thorax, Ospedale Morgagni-Pierantoni, Forlì, Italy

    Silvia Puglisi, Claudia Ravaglia, Antonella Arcadu, Sara Tomassetti & Venerino Poletti

  2. Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark

    Venerino Poletti

Authors
  1. Silvia Puglisi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claudia Ravaglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonella Arcadu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sara Tomassetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Venerino Poletti
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Diseases of the Thorax, Ospedale Morgagni-Pierantoni, Forlì, Italy

    Venerino Poletti

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Puglisi, S., Ravaglia, C., Arcadu, A., Tomassetti, S., Poletti, V. (2019). Clinical Meaning of Transbronchial Cryobiopsy. In: Poletti, V. (eds) Transbronchial cryobiopsy in diffuse parenchymal lung disease. Springer, Cham. https://doi.org/10.1007/978-3-030-14891-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-14891-1_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-14890-4

  • Online ISBN: 978-3-030-14891-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation