Abstract
Allergic rhinitis (AR) follows a 24-h diurnal pattern of variation in symptoms. A study by Reinberg et al. recruited 765 patients with AR and followed them for over an 11-month period. Participants self-assessed severity of symptoms such as sneezing, rhinorrhea, obstruction, pruritus of the eyes and nose, cough and/or wheezing four times daily over a 1-week period via visual analogue scales. Overall, symptoms were reported to be the most severe in the morning with a mild peak in early evening. In addition, circannual changes in allergic reactivity were noted.
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Cosper, A., Oppenheimer, J., Cox, L. (2019). Circadian Rhythm of Allergic Rhinitis, Skin Testing and Allergen Immunotherapy. In: Fishbein, A., Sheldon, S. (eds) Allergy and Sleep. Springer, Cham. https://doi.org/10.1007/978-3-030-14738-9_19
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