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Flammer Syndrome pp 265–275Cite as

Individualised Patient Profile: Risk Assessment by the Patient’s Self-Report and Potential Clinical Utility of Flammer Syndrome Phenotype

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Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 11))

Abstract

Herewith we introduce a selected patient case, who evidently demonstrates Flammer syndrome signs and symptoms which might be strongly indicative for predictive diagnostic approaches and targeted preventive measures, if a correct interpretation would be made well in time. A self-report is presented.

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References

  1. https://www.springernature.com/gp/researchers/campaigns/change-the-world?wt_mc=SocialMedia.Twitter.10.CON417.ctw2018_tw_shared_button&utm_medium=socialmedia&utm_source=twitter&utm_content=ctw2018_tw_shared_button&utm_campaign=10_dann_ctw2018_tw_shared_button

  2. https://www.springernature.com/gp/researchers/campaigns/change-the-world/medicine-public-health

  3. LeBlanc TW, Abernethy AP (2017) Patient-reported outcomes in cancer care – hearing the patient voice at greater volume. Nat Rev Clin Oncol 14:763–772. https://doi.org/10.1038/nrclinonc.2017.153

    Article  PubMed  Google Scholar 

  4. Golubnitschaja O, Flammer J (2018) Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine. EPMA J 9(1):15–20. https://doi.org/10.1007/s13167-018-0127-9

    Article  PubMed  PubMed Central  Google Scholar 

  5. Konieczka K, Ritch R, Traverso CE, Kim DM, Kook MS, Gallino A, Golubnitschaja O, Erb C, Reitsamer HA, Kida T, Kurysheva N, Yao K (2014) Flammer syndrome. EPMA J 5(1):11. https://doi.org/10.1186/1878-5085-5-11

    Article  PubMed  PubMed Central  Google Scholar 

  6. Avishai E, Yeghiazaryan K, Golubnitschaja O (2017) Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine. EPMA J 8(1):23–33. https://doi.org/10.1007/s13167-017-0081-y

    Article  PubMed  PubMed Central  Google Scholar 

  7. Flammer J, Konieczka K (2017) The discovery of the Flammer syndrome: a historical and personal perspective. EPMA J 8(2):75–97. https://doi.org/10.1007/s13167-017-0090-x

    Article  PubMed  PubMed Central  Google Scholar 

  8. Konieczka K, Flammer J (2016) Phenomenology and clinical relevance of the Flammer syndrome. Klin Monatsbl Augenheilkd 233(12):1331–1336

    Article  CAS  PubMed  Google Scholar 

  9. Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pešta M, Costigliola V, Grech G (2016) Breast cancer epidemic in the early 21st century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumor Biol 37(10):12941–12957. https://doi.org/10.1007/s13277-016-5168-x

    Article  Google Scholar 

  10. Golubnitschaja O (2017) Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification? EPMA J 8(1):17–22. https://doi.org/10.1007/s13167-017-0086-6

    Article  PubMed  PubMed Central  Google Scholar 

  11. Gasser P, Flammer J (1991) Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high- tension glaucoma. Am J Ophthalmol 111(5):585–588

    Article  CAS  PubMed  Google Scholar 

  12. Gugleta K, Zawinka C, Rickenbacher I, Kochkorov A, Katamay R, Flammer J, Orgul S (2006) Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity. Invest Ophthalmol Vis Sci 47(9):4034–4041

    Article  PubMed  Google Scholar 

  13. Flammer J, Konieczka K (2015) Retinal venous pressure: the role of endothelin. EPMA J 6:21. https://doi.org/10.1186/s13167-015-0043-1

    Article  PubMed  PubMed Central  Google Scholar 

  14. Todorova MG, Josifova T, Konieczka K (2015) Endothelin-1 plasma levels in patients with both retinitis pigmentosa and Flammer syndrome. Klin Monatsbl Augenheilkd 232(4):514–518. https://doi.org/10.1055/s-0035-1545674

    Article  CAS  PubMed  Google Scholar 

  15. Golubnitschaja O, Yeghiazaryan K, Flammer J (2010) Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible? EPMA J 1(2):237–244. https://doi.org/10.1007/s13167-010-0031-4

    Article  PubMed  PubMed Central  Google Scholar 

  16. Yeghiazaryan K, Flammer J, Golubnitschaja O (2010) Predictive molecular profiling in blood of healthy vasospastic individuals: clue to targeted prevention as personalised medicine to effective costs. EPMA J 1(2):263–272. https://doi.org/10.1007/s13167-010-0032-3

    Article  PubMed  PubMed Central  Google Scholar 

  17. Flammer J, Konieczka K, Flammer AJ (2013) The primary vascular dysregulation syndrome: implications for eye diseases. EPMA J 4(1):14. https://doi.org/10.1186/1878-5085-4-14

    Article  PubMed  PubMed Central  Google Scholar 

  18. Konieczka K, Flammer AJ, Todorova M, Meyer P, Flammer J (2012) Retinitis pigmentosa and ocular blood flow. EPMA J 3(1):17. https://doi.org/10.1186/1878-5085-3-17

    Article  PubMed  PubMed Central  Google Scholar 

  19. Konieczka K, Flammer J, Sternbuch J, Binggeli T, Fraenkl S (2017) Leber's hereditary optic neuropathy, Normal tension Glaucoma, and Flammer syndrome: long term follow-up of a patient. Klin Monatsbl Augenheilkd 234(4):584–587. https://doi.org/10.1055/s-0042-119564

    Article  CAS  PubMed  Google Scholar 

  20. Konieczka K, Choi HJ, Koch S, Fankhauser F, Schoetzau A, Kim DM (2017) Relationship between normal tension glaucoma and Flammer syndrome. EPMA J 8(2):111–117. https://doi.org/10.1007/s13167-017-0097-3

    Article  PubMed  PubMed Central  Google Scholar 

  21. Konieczka K, Erb C (2017) Diseases potentially related to Flammer syndrome. EPMA J 8(4):327–332. https://doi.org/10.1007/s13167-017-0116-4

    Article  PubMed  PubMed Central  Google Scholar 

  22. Bubnov R, Polivka J Jr, Zubor P, Koniczka K, Golubnitschaja O (2017) Pre-metastatic niches in breast cancer: are they created by or prior to the tumour onset? “Flammer syndrome” relevance to address the question. EPMA J 8(2):141–157. https://doi.org/10.1007/s13167-017-0092-8

    Article  PubMed  PubMed Central  Google Scholar 

  23. Golubnitschaja O, Debald M, Kuhn W, Yeghiazaryan K, Bubnov RV, Goncharenko VM, Lushchyk U, Grech G, Konieczka K (2016) Flammer syndrome and potential formation of pre-metastatic niches: a multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease. EPMA J 7(Suppl 1):9.,A25. https://doi.org/10.1186/s13167-016-0054-6

    Article  PubMed Central  Google Scholar 

  24. Teuchner B, Orgül S, Ulmer H, Haufschild T, Flammer J (2004) Reduced thirst in patients with a vasospastic syndrome. Acta Ophthalmol Scand 82(6):738–740

    Article  PubMed  Google Scholar 

  25. Borkum JM (2016) Migraine triggers and oxidative stress: a narrative review and synthesis. Headache 56(1):12–35. https://doi.org/10.1111/head.12725

    Article  PubMed  Google Scholar 

  26. Kleiner SM (1999) Water: an essential but overlooked nutrient. J Am Diet Assoc 99(2):200–206. https://doi.org/10.1155/2015/482839

    Article  CAS  PubMed  Google Scholar 

  27. Babak B, Golubnitschaja O (2017) The potential relationship between Flammer and Sjögren syndromes: the chime of dysfunction. EPMA J 8(4):333–338. https://doi.org/10.1007/s13167-017-0107-5

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Radiological Clinic, UKB, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  2. Breast Cancer Research Centre, UKB, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  3. Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  4. Department of Ophthalmology, University of Basel, Basel, Switzerland

    Josef Flammer

Authors
  1. Olga Golubnitschaja
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  2. Josef Flammer
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Corresponding author

Correspondence to Olga Golubnitschaja .

Editor information

Editors and Affiliations

  1. Department of Radiology, Friedrich-Wilhelms-University in Bonn, Bonn, Nordrhein-Westfalen, Germany

    Olga Golubnitschaja

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Golubnitschaja, O., Flammer, J. (2019). Individualised Patient Profile: Risk Assessment by the Patient’s Self-Report and Potential Clinical Utility of Flammer Syndrome Phenotype. In: Golubnitschaja, O. (eds) Flammer Syndrome. Advances in Predictive, Preventive and Personalised Medicine, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-13550-8_15

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  • DOI: https://doi.org/10.1007/978-3-030-13550-8_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-13549-2

  • Online ISBN: 978-3-030-13550-8

  • eBook Packages: MedicineMedicine (R0)

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