Skip to main content

Esophageal Obstruction and Perforation: Incidence, Etiologies, Presentation, and Management

  • Chapter
  • First Online:
  • 569 Accesses

Abstract

Esophageal perforation or obstruction is overall a rare but serious entity with mortality rates as high as 30%. Often discussed but rarely encountered, it requires correct and complex decision-making to ensure an optimal outcome for the patient. Throughout the literature, it is difficult to find all-encompassing discussions on esophageal perforation or obstruction and its management. Esophageal obstruction is broadly divided into benign and malignant etiologies. Overall, the most common etiology is for benign causes such as caustic ingestions, foreign body impactions, strictures, dysmotility, and hernias. Perforation is most commonly iatrogenic occurring during instrumentation of the esophagus; however there is typically an underlying associated pathology.

The acute management of esophageal perforation is dictated by location of the injury, underlying comorbid conditions, and the level of physiologic derangement. Presentation of perforation is varied, non-specific, and dependent on location. The gold standard for imaging is thin barium esophagram, but CT chest is an excellent alternative. Surgical repair of perforation involves circumferential dissection and mobilization with full exposure of the perforation via myotomy. The approach depends on the level of perforation. The repair should be buttressed with tissue such as muscle flap, pericardial fat pad, or pleura. Perforations secondary to malignancy should be approached with caution, and definitive oncological resection should not be undertaken in the same procedure; instead temporizing measures are preferred. Esophageal diversion is becoming less common. In hemodynamically unstable patients, with a large defect or nonviable esophageal tissue, diversion or resection with discontinuity may serve as a damage control option.

Obstructions are initially managed with securing the airway and then using diagnostic imaging to determine the cause. Food impaction is managed endoscopically or pharmacologically. Malignant obstruction management requires a multimodal approach, and primary resection should not to be undertaken in the acute care setting due to frailty in the majority of this patient population. Chronic obstructive pathology such as strictures and dysmotility disorders is primarily managed with endoscopy with surgical intervention reserved for young, fit patients or those who fail endoscopic therapy.

The purpose of this chapter is to provide a discussion on basic anatomy and physiology of the esophagus and the etiology of obstruction and perforation. The presentation of acute and chronic esophageal perforations and obstruction, as well as the management of each entity, will also be discussed.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Oezcelik A, DeMeester SR. General anatomy of the esophagus. Thorac Surg Clin. 2011;21(2):289–97. x

    Article  PubMed  Google Scholar 

  2. Patel D, Vaezi MF. Normal esophageal physiology and laryngopharyngeal reflux. Otolaryngol Clin N Am. 2013;46(6):1023–41.

    Article  Google Scholar 

  3. Rice TW, Bronner MP. The esophageal wall. Thorac Surg Clin. 2011;21(2):299–305, x.

    Article  PubMed  Google Scholar 

  4. Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends – an update. Cancer Epidemiol Biomark Prev. 2016;25(1):16–27.

    Article  Google Scholar 

  5. Lagergren J, Smyth E, Cunningham D, Lagergren P. Oesophageal cancer. Lancet. 2017;390(10110):2383–96.

    Article  PubMed  Google Scholar 

  6. Bharat A, Crabtree T. Management of advanced-stage operable esophageal cancer. Surg Clin North Am. 2012;92(5):1179–97.

    Article  PubMed  Google Scholar 

  7. Smith CD. Esophageal strictures and diverticula. Surg Clin North Am. 2015;95(3):669–81.

    Article  PubMed  Google Scholar 

  8. Gummin DD, Mowry JB, Spyker DA, Brooks DE, Fraser MO, Banner W. 2016 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 34th annual report. Clin Toxicol (Phila). 2017;55(10):1072–252.

    Article  Google Scholar 

  9. Kurowski JA, Kay M. Caustic ingestions and foreign bodies ingestions in pediatric patients. Pediatr Clin N Am. 2017;64(3):507–24.

    Article  Google Scholar 

  10. Triadafilopoulos G, Roorda A, Akiyama J. Update on foreign bodies in the esophagus: diagnosis and management. Curr Gastroenterol Rep. 2013;15(4):317.

    Article  PubMed  Google Scholar 

  11. Stavropoulos SN, Friedel D, Modayil R, Parkman HP. Diagnosis and management of esophageal achalasia. BMJ. 2016;354:i2785.

    Article  PubMed  Google Scholar 

  12. Uppal DS, Wang AY. Update on the endoscopic treatments for achalasia. World J Gastroenterol. 2016;22(39):8670–83.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Bowers SP. Esophageal motility disorders. Surg Clin North Am. 2015;95(3):467–82.

    Article  PubMed  Google Scholar 

  14. Pregun I, Hritz I, Tulassay Z, Herszenyi L. Peptic esophageal stricture: medical treatment. Dig Dis. 2009;27(1):31–7.

    Article  PubMed  Google Scholar 

  15. Andolfi C, Jalilvand A, Plana A, Fisichella PM. Surgical treatment of paraesophageal hernias: a review. J Laparoendosc Adv Surg Tech A. 2016;26(10):778–83.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Schieman C, Grondin SC. Paraesophageal hernia: clinical presentation, evaluation, and management controversies. Thorac Surg Clin. 2009;19(4):473–84.

    Article  PubMed  Google Scholar 

  17. Rashid F, Thangarajah T, Mulvey D, Larvin M, Iftikhar SY. A review article on gastric volvulus: a challenge to diagnosis and management. Int J Surg. 2010;8(1):18–24.

    Article  CAS  PubMed  Google Scholar 

  18. Muller M, Gockel I, Hedwig P, Eckardt AJ, Kuhr K, Konig J, et al. Is the Schatzki ring a unique esophageal entity? World J Gastroenterol. 2011;17(23):2838–43.

    PubMed  PubMed Central  Google Scholar 

  19. Furuta GT, Katzka DA. Eosinophilic esophagitis. N Engl J Med. 2015;373(17):1640–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Hiremath GS, Hameed F, Pacheco A, Olive A, Davis CM, Shulman RJ. Esophageal food impaction and eosinophilic esophagitis: a retrospective study, systematic review, and meta-analysis. Dig Dis Sci. 2015;60(11):3181–93.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Dellon ES. Epidemiology of eosinophilic esophagitis. Gastroenterol Clin N Am. 2014;43(2):201–18.

    Article  Google Scholar 

  22. Polguj M, Chrzanowski L, Kasprzak JD, Stefanczyk L, Topol M, Majos A. The aberrant right subclavian artery (arteria lusoria): the morphological and clinical aspects of one of the most important variations – a systematic study of 141 reports. Sci World J. 2014;2014:292734.

    Article  Google Scholar 

  23. Okumus M, Ozkan F, Bozkurt S, Dogan M, Tokur M, Kapci M. Arteria lusoria: a very rare cause of esophageal obstruction in a hypoxemic patient. Turk J Gastroenterol. 2014;25(4):433–4.

    Article  PubMed  Google Scholar 

  24. Petrone P, Kassimi K, Jimenez-Gomez M, Betancourt A, Axelrad A, Marini CP. Management of esophageal injuries secondary to trauma. Injury. 2017;48(8):1735–42.

    Article  PubMed  Google Scholar 

  25. Kaman L, Iqbal J, Kundil B, Kochhar R. Management of Esophageal Perforation in adults. Gastroenterology Res. 2010;3(6):235–44.

    PubMed  PubMed Central  Google Scholar 

  26. de Schipper JP, Pull ter Gunne AF, Oostvogel HJ, van Laarhoven CJ. Spontaneous rupture of the oesophagus: Boerhaave’s syndrome in 2008. Literature review and treatment algorithm. Dig Surg. 2009;26(1):1–6.

    Article  PubMed  Google Scholar 

  27. Aiolfi A, Inaba K, Recinos G, Khor D, Benjamin ER, Lam L, et al. Non-iatrogenic esophageal injury: a retrospective analysis from the National Trauma Data Bank. World J Emerg Surg. 2017;12:19.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Hurtgen M, Herber SC. Treatment of malignant tracheoesophageal fistula. Thorac Surg Clin. 2014;24(1):117–27.

    Article  PubMed  Google Scholar 

  29. Reed MF, Mathisen DJ. Tracheoesophageal fistula. Chest Surg Clin N Am. 2003;13(2):271–89.

    Article  PubMed  Google Scholar 

  30. Zhou C, Hu Y, Xiao Y, Yin W. Current treatment of tracheoesophageal fistula. Ther Adv Respir Dis. 2017;11(4):173–80.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Nirula R. Esophageal perforation. Surg Clin North Am. 2014;94(1):35–41.

    Article  PubMed  Google Scholar 

  32. Obeso Carillo GA, Blanco Ramos M, Garcia Fontan EM, Perez Pedrosa A, Gil Gil P. Perforated pharyngoesophageal diverticulum as a cause of cervical infection with mediastinal extension. Cir Esp. 2012;90(8):533–5.

    Article  PubMed  Google Scholar 

  33. Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Ann Thorac Surg. 2004;77(4):1475–83.

    Article  PubMed  Google Scholar 

  34. Cheng Q, Liu B. Treatment of cervical esophageal perforation. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery). 2013;27(18):989–90, 94.

    Google Scholar 

  35. Zenga J, Kreisel D, Kushnir VM, Rich JT. Management of cervical esophageal and hypopharyngeal perforations. Am J Otolaryngol. 2015;36(5):678–85.

    Article  PubMed  Google Scholar 

  36. Mann W, Munker G. Drainage of deep mediastinal infections following perforation of the cervical esophagus (author’s transl). HNO. 1975;23(11):355–7.

    CAS  PubMed  Google Scholar 

  37. Nakano T, Onodera K, Ichikawa H, Kamei T, Taniyama Y, Sakurai T, et al. Thoracoscopic primary repair with mediastinal drainage is a viable option for patients with Boerhaave’s syndrome. J Thorac Dis. 2018;10(2):784–9.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Pezzetta E, Kokudo T, Uldry E, Yamaguchi T, Kudo H, Ris HB, et al. The surgical management of spontaneous esophageal perforation (Boerhaave’s syndrome) 20 years of experience. Biosci Trends. 2016;10(2):120–4.

    Article  PubMed  Google Scholar 

  39. Bufkin BL, Miller JI Jr, Mansour KA. Esophageal perforation: emphasis on management. Ann Thorac Surg. 1996;61(5):1447–51; discussion 51–2.

    Article  CAS  PubMed  Google Scholar 

  40. Freeman RK, Ascioti AJ, Giannini T, Mahidhara RJ. Analysis of unsuccessful esophageal stent placements for esophageal perforation, fistula, or anastomotic leak. Ann Thorac Surg. 2012;94(3):959–64; discussion 64–5.

    Article  PubMed  Google Scholar 

  41. Nakabayashi T, Kudo M, Hirasawa T, Kuwano H. Successful late management of esophageal perforation with T-tube drainage. Case Rep Gastroenterol. 2008;2(1):67–70.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Naylor AR, Walker WS, Dark J, Cameron EW. T tube intubation in the management of seriously ill patients with oesophagopleural fistulae. Br J Surg. 1990;77(1):40–2.

    Article  CAS  PubMed  Google Scholar 

  43. Abu-Daff S, Shamji F, Ivanovic J, Villeneuve PJ, Gilbert S, Maziak DE, et al. Esophagectomy in esophageal perforations: an analysis. Dis Esophagus. 2016;29(1):34–40.

    Article  CAS  PubMed  Google Scholar 

  44. Seo YD, Lin J, Chang AC, Orringer MB, Lynch WR, Reddy RM. Emergent esophagectomy for esophageal perforations: a safe option. Ann Thorac Surg. 2015;100(3):905–9.

    Article  PubMed  Google Scholar 

  45. Bekkerman M, Sachdev AH, Andrade J, Twersky Y, Iqbal S. Endoscopic management of foreign bodies in the gastrointestinal tract: a review of the literature. Gastroenterol Res Pract. 2016;2016:8520767.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Ko HH, Enns R. Review of food bolus management. Can J Gastroenterol. 2008;22(10):805–8.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Khayyat YM. Pharmacological management of esophageal food bolus impaction. Emerg Med Int. 2013;2013:924015.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G, et al. Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e44S–88S.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Committee ASoP, Ikenberry SO, Jue TL, Anderson MA, Appalaneni V, Banerjee S, et al. Management of ingested foreign bodies and food impactions. Gastrointest Endosc. 2011;73(6):1085–91.

    Article  Google Scholar 

  50. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.

    Article  PubMed  Google Scholar 

  51. Kinsinger S. Elevated cancer risk perceptions among patients with Barrett’s esophagus: do psychological factors play a role? Dis Esophagus. 2018;31(4).

    Google Scholar 

  52. Spechler S. Barrett esophagus and risk of esophageal cancer: a clinical review. JAMA. 2013;310(6):627–36.

    Article  CAS  PubMed  Google Scholar 

  53. Thrift AP. Barrett’s esophagus and esophageal adenocarcinoma: how common are they really? Dig Dis Sci. 2018;63(8):1988–96.

    Article  PubMed  Google Scholar 

  54. Lim H, Kim DH, Jung HY, Gong EJ, Na HK, Ahn JY, et al. Clinical significance of early detection of esophageal cancer in patients with head and neck cancer. Gut Liver. 2015;9(2):159–65.

    Article  CAS  PubMed  Google Scholar 

  55. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 1980;69(4):491–7.

    Article  CAS  PubMed  Google Scholar 

  56. Yang CW, Lin HH, Hsieh TY, Chang WK. Palliative enteral feeding for patients with malignant esophageal obstruction: a retrospective study. BMC Palliat Care. 2015;14:58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Knyrim K, Wagner HJ, Bethge N, Keymling M, Vakil N. A controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancer. N Engl J Med. 1993;329(18):1302–7.

    Article  CAS  PubMed  Google Scholar 

  58. Cwikiel M, Cwikiel W, Albertsson M. Palliation of dysphagia in patients with malignant esophageal strictures. Comparison of results of radiotherapy, chemotherapy and esophageal stent treatment. Acta oncologica (Stockholm, Sweden). 1996;35(1):75–9.

    Article  CAS  Google Scholar 

  59. Dai Y, Li C, Xie Y, Liu X, Zhang J, Zhou J, et al. Interventions for dysphagia in oesophageal cancer. Cochrane Database Syst Rev. 2014;10:Cd005048.

    Google Scholar 

  60. Dicle O, Goktay AY, Akbaylar H. Palliation of malignant esophageal strictures: initial results with self-expanding uncovered nitinol coil stents. Eur Radiol. 1999;9(7):1418–22.

    Article  CAS  PubMed  Google Scholar 

  61. Bassi M, Luigiano C, Fabbri C, Ferrara F, Ghersi S, Alibrandi A, et al. Large diameter fully covered self-expanding metal stent placement for palliation of proximal malignant esophageal strictures. Dis Esophagus. 2015;28(6):579–84.

    Article  CAS  PubMed  Google Scholar 

  62. Iwasaki H, Mizushima T, Suzuki Y, Fukusada S, Kachi K, Ozeki T, et al. Factors that affect stent-related complications in patients with malignant obstruction of the esophagus or gastric cardia. Gut Liver. 2017;11(1):47–54.

    Article  PubMed  Google Scholar 

  63. Wang MQ, Sze DY, Wang ZP, Wang ZQ, Gao YA, Dake MD. Delayed complications after esophageal stent placement for treatment of malignant esophageal obstructions and esophagorespiratory fistulas. J Vasc Interv Radiol (JVIR). 2001;12(4):465–74.

    Article  CAS  Google Scholar 

  64. Homann N, Noftz MR, Klingenberg-Noftz RD, Ludwig D. Delayed complications after placement of self-expanding stents in malignant esophageal obstruction: treatment strategies and survival rate. Dig Dis Sci. 2008;53(2):334–40.

    Article  PubMed  Google Scholar 

  65. Sumiyoshi T, Gotoda T, Muro K, Rembacken B, Goto M, Sumiyoshi Y, et al. Morbidity and mortality after self-expandable metallic stent placement in patients with progressive or recurrent esophageal cancer after chemoradiotherapy. Gastrointest Endosc. 2003;57(7):882–5.

    Article  PubMed  Google Scholar 

  66. Poincloux L, Sautel C, Rouquette O, Pereira B, Goutte M, Bommelaer G, et al. The clinical outcome in patients treated with a newly designed SEMS in cervical esophageal strictures and fistulas. J Clin Gastroenterol. 2016;50(5):379–87.

    CAS  PubMed  Google Scholar 

  67. Lian JJ, Ma LL, Hu JW, Chen SY, Qin WZ, Xu MD, et al. Endoscopic balloon dilatation for benign esophageal stricture after endoscopic submucosal dissection for early esophageal neoplasms. J Dig Dis. 2014;15(5):224–9.

    Article  PubMed  Google Scholar 

  68. Zehetner J, DeMeester SR, Ayazi S, Demeester TR. Home self-dilatation for esophageal strictures. Dis Esophagus. 2014;27(1):1–4.

    Article  CAS  PubMed  Google Scholar 

  69. Suzuki T, Siddiqui A, Taylor LJ, Cox K, Hasan RA, Laique SN, et al. Clinical outcomes, efficacy, and adverse events in patients undergoing esophageal stent placement for benign indications: a large multicenter study. J Clin Gastroenterol. 2016;50(5):373–8.

    PubMed  Google Scholar 

  70. Clayton SB, Castell DO. Multiple good options are available for achalasia management. J Clin Gastroenterol. 2015;49(3):194–8.

    Article  PubMed  Google Scholar 

  71. Pandolfino JE, Gawron AJ. Achalasia: a systematic review. JAMA. 2015;313(18):1841–52.

    Article  PubMed  Google Scholar 

  72. Patti MG, Fisichella PM. Controversies in management of achalasia. J Gastrointest Surg. 2014;18(9):1705–9.

    Article  PubMed  Google Scholar 

  73. Polguj M, Chrzanowski L, Kasprzak JD, Stefanczyk L, Topol M, Majos A. The aberrant right subclavian artery (arteria lusoria): the morphological and clinical aspects of one of the most important variations–a systematic study of 141 reports. ScientificWorldJournal. 2014;2014:292734.

    Article  PubMed  PubMed Central  Google Scholar 

  74. von Segesser L, Faidutti B. Symptomatic aberrant retro-esophageal subclavian artery: considerations about the surgical approach, management and results. Thorac Cardiovasc Surg. 1984;32(5):307–10.

    Article  Google Scholar 

  75. Tanaka A, Milner R, Ota T. Kommerell’s diverticulum in the current era: a comprehensive review. Gen Thorac Cardiovasc Surg. 2015;63(5):245–59.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mia DeBarros .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

DeBarros, M., Cuadrado, D.G. (2019). Esophageal Obstruction and Perforation: Incidence, Etiologies, Presentation, and Management. In: Lim, R. (eds) Multidisciplinary Approaches to Common Surgical Problems. Springer, Cham. https://doi.org/10.1007/978-3-030-12823-4_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-12823-4_33

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-12822-7

  • Online ISBN: 978-3-030-12823-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics