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Hypoxia and Metabolism in Metastasis

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Hypoxia and Cancer Metastasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1136))

Abstract

The hypoxic microenvironment is one of the major features of solid tumors, which regulates cell malignancy in multiple ways. As a response to hypoxia, a large number of target genes involved in cell growth, metabolism, metastasis and immunity are activated in cancer cells. Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1β subunit and an oxygen sensitive HIF-1α subunit, thus, adapts to decreased oxygen availability as a transcriptional factor. HIF-1 regulates many genes involved in tumorigenesis. Here, we focus on cancer cell metabolism and metastasis regulated by hypoxia.

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Acknowledgments

This work was supported in part by grants from the National Natural Science Foundation of China (81525022), the strategic priority research program(Pilot study)of the Chinese Academy of Sciences (XDPB10), and the major innovative program of development foundation of Hefei center for physical science and technology (2017FXZY004).

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Correspondence to Huafeng Zhang .

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Zhang, T., Suo, C., Zheng, C., Zhang, H. (2019). Hypoxia and Metabolism in Metastasis. In: Gilkes, D. (eds) Hypoxia and Cancer Metastasis. Advances in Experimental Medicine and Biology, vol 1136. Springer, Cham. https://doi.org/10.1007/978-3-030-12734-3_6

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