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Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders pp 59–87Cite as

Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring

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Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1134))

Abstract

Early epidemiology studies in humans have and continue to offer valuable insight into the Developmental Origins of Health and Disease (DOHaD) hypothesis, which emphasises the importance of early-life nutritional and environmental changes on the increased risk of metabolic and reproductive disease in later life. Human studies are limited and constrained by a range of factors which do not apply to preclinical research. Animal models therefore offer a unique opportunity to fully investigate the mechanisms associated with developmental programming, helping to elucidate the developmental processes which influence reproductive diseases, and highlight potential biomarkers which can be translated back to the human condition. This review covers the use and limitations of a number of animal models frequently utilised in developmental programming investigations, with an emphasis on dietary manipulations which can lead to reproductive dysfunction in offspring.

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Authors and Affiliations

  1. The Liggins Institute, University of Auckland, Auckland, New Zealand

    Pania E. Bridge-Comer, Mark H. Vickers & Clare M. Reynolds

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  1. Pania E. Bridge-Comer
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  2. Mark H. Vickers
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  3. Clare M. Reynolds
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Correspondence to Mark H. Vickers .

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  1. Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Bridge-Comer, P.E., Vickers, M.H., Reynolds, C.M. (2019). Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring. In: Guest, P. (eds) Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders. Advances in Experimental Medicine and Biology(), vol 1134. Springer, Cham. https://doi.org/10.1007/978-3-030-12668-1_4

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