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Calcium Signaling pp 445–469Cite as

Molecular Basis and Regulation of Store-Operated Calcium Entry

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1131))

Abstract

Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that communicates the information about the amount of Ca2+ accumulated in the intracellular Ca2+ stores to the plasma membrane channels and the nature of these channels have been matters of intense investigation and debate. The stromal interaction molecule-1 (STIM1) has been identified as the Ca2+ sensor of the intracellular Ca2+ compartments that activates the store-operated channels. STIM1 regulates two types of store-dependent channels: the Ca2+ release-activated Ca2+ (CRAC) channels, formed by Orai1 subunits, that conduct the highly Ca2+ selective current I CRAC and the cation permeable store-operated Ca2+ (SOC) channels, which consist of Orai1 and TRPC1 proteins and conduct the non-selective current I SOC. While the crystal structure of Drosophila CRAC channel has already been solved, the architecture of the SOC channels still remains unclear. The dynamic interaction of STIM1 with the store-operated channels is modulated by a number of proteins that either support the formation of the functional STIM1-channel complex or protect the cell against Ca2+ overload.

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Abbreviations

[Ca2+]c :

cytosolic free Ca2+ concentration

AMPA:

alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate

CRAC channels:

Ca2+-release activated Ca2+ channels

CTID:

C-terminal inhibitory domain

ER:

endoplasmic reticulum

IP3 :

inositol 1,4,5-trisphosphate

NAADP:

nicotinic acid adenine dinucleotide phosphate

NMDA:

N-methyl-D-aspartate

OAG:

1-oleoyl-2-acetyl-sn-glycerol

PM:

plasma membrane

ROC:

receptor-operated channels

ROS:

reactive oxygen species

SERCA:

sarco/endoplasmic reticulum Ca2+ ATPase

SMOC:

second messenger-operated channels

SOAP:

STIM1-Orai1 Association Pocket

SOC channels:

store-operated Ca2+ channels

SOCE:

store-operated Ca2+ entry

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Acknowledgements

This work was supported by MINECO (Grant BFU2016-74932-C2-1-P/2-P) and Junta de Extremadura-FEDER (IB16046 and GR18061). IJ and JJL were supported by Juan de la Cierva Program (IJCI_2015-25665) and Junta de Extremadura-FEDER (IB16046), respectively.

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Authors and Affiliations

  1. Department of Physiology, Cell Physiology Research Group and Institute of Molecular Pathology Biomarkers, University of Extremadura, Cáceres, Spain

    Jose J. Lopez, Isaac Jardin, Letizia Albarrán, Jose Sanchez-Collado, Carlos Cantonero, Gines M. Salido & Juan A. Rosado

  2. Department of Medical Physiology and Biophysics and Group of Cardiovascular Pathophysiology, Institute of Biomedicine of Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/University of Sevilla, Sevilla, Spain

    Tarik Smani

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  1. Jose J. Lopez
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Correspondence to Isaac Jardin .

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  1. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Lopez, J.J. et al. (2020). Molecular Basis and Regulation of Store-Operated Calcium Entry. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-030-12457-1_17

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