Abstract
Despite significant improvements in cancer pain management with the introduction of the World Health Organization (WHO) Step Ladder in 1984, 10–20% of cancer patients experience severe pain. For these patients, and for those who may not be able to tolerate comprehensive medical management, intrathecal therapy may be an integral component of their pain management. In this chapter, we discuss the general presentation of cancer pain, indications and uses for IDDS, surgical considerations for cancer pain patients, efficacy and evidence for IDDS in cancer pain, alternatives such as externalized neuraxial therapy, and considerations for end of life care.
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Bentley JN, Viswanathan A, Rosenberg WS, Patil PG. Treatment of medically refractory cancer pain with a combination of intrathecal neuromodulation and neurosurgical ablation: case series and literature review. Pain Med. 2014;15(9):1488–95.
Bernards CM. Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs. Anesthesiology. 2006;105(1):169–78.
Bolash R, Udeh B, Saweris Y, Guirguis M, Dalton JE, Makarova N, Mekhail N. Longevity and cost of implantable intrathecal drug delivery systems for chronic pain management: a retrospective analysis of 365 patients. Neuromodulation. 2015;18(2):150–5.
Brogan SE, Winter NB, Abiodun A, Safarpour R. A cost utilization analysis of intrathecal therapy for refractory cancer pain: identifying factors associated with cost benefit. Pain Med. 2013;14(4):478–86.
Deer TR, Smith HS, Burton AW, Pope JE, Doleys DM, Levy RM, et al. Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain. Pain Physician. 2011;14(3):E283–312.
Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, et al. The Polyanalgesic Consensus Conference (PACC): recommendations on intrathecal drug infusion systems best practices and guidelines. Neuromodulation. 2017;20(2):96–132.
Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, et al. The Polyanalgesic Consensus Conference (PACC): recommendations for intrathecal drug delivery: guidance for improving safety and mitigating risks: guidance for improving safety and mitigating risks. Neuromodulation. 2017;20(2):155–76.
Engle MP, Vinh BP, Harun N, Koyyalagunta D. Infectious complications related to intrathecal drug delivery system and spinal cord stimulator system implantations at a comprehensive cancer pain center. Pain Physician. 2013;16(3):251–7.
Mueller-Schwefe G, Hassenbusch SJ, Reig E. Cost effectiveness of intrathecal therapy for pain. Neuromodulation. 1999;2(2):77–87.
Payne WG, Naidu DK, Wheeler CK, Barkoe D, Mentis M, Salas RE, et al. Wound healing in patients with cancer. Eplasty. 2008;8:e9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206003/.
Seretny M, Currie GL, Sena ES. Incidence, prevalence, and predictors of chemotherapy- induced peripheral neuropathy: a systematic review and meta-analysis. Pain. 2014;155(12):2461–70.
Shaiova L. Difficult pain syndromes: bone pain, visceral pain, and neuropathic pain. Cancer J. 2006;12(5):330–40.
Smith TJ, Staats PS, Deer T, Sterns LJ, Boortz-Marx RL, Buchser E, Catala E, Bryce DA, Coyne PJ, Pool GE. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2002;20(19):4040–9.
Stearns L, Boortz-Marx R, Du Pen S, Friehs G, Gordon M, Halyard M, et al. Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. J Support Oncol. 2005;3(6):399–408.
Stearns LJ, Hinnenthal JA, Hammond K, Berryman E, Janjan NA. Health services utilization and payments in patients with cancer pain: a comparison of intrathecal drug delivery vs. conventional medical management. Neuromodulation. 2016;19(2):196–205.
Zheng S, He L, Yang X, Li X, Yang Z. Evaluation of intrathecal drug delivery system for intractable pain in advanced malignancies: a prospective cohort study. Medicine. 2017;96(11):e6354.
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Shah, A.C., Ike, K., Stearns, L., Poree, L.R. (2019). Implantable Drug Delivery Systems for Cancer Pain and End of Life Care. In: Deer, T., Pope, J., Lamer, T., Provenzano, D. (eds) Deer's Treatment of Pain. Springer, Cham. https://doi.org/10.1007/978-3-030-12281-2_83
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DOI: https://doi.org/10.1007/978-3-030-12281-2_83
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