Cine and Multicontrast Late Enhanced MRI Registration for 3D Heart Model Construction

Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11395)


Cardiac MR imaging using multicontrast late enhancement (MCLE) acquisition provides a way to identify myocardium infarct scar and arrhythmia foci in the peri-infarct. In image-guided RF ablations of ventricular arrhythmia and computational modeling of cardiac function, construction of a 3D heart model is required but this is hampered by the challenges in myocardium segmentation and slice misalignment in MCLE images. Here we developed an approach for cine and MCLE registration, and MCLE scar-cine myocardium label fusion to build high-fidelity 3D heart models. MCLE-cine image alignment was initialized using a block-matching-based rigid registration approach followed by a deformable registration refinement step. The deformable registration approach employed a self similarity context descriptor for image similarity measurements, optical flow as a transformation model and convex optimization to derive the optimal solution. We applied the developed approach to a preclinical dataset of 10 pigs with myocardium infarction and evaluated the registration accuracy by comparing cine and MCLE myocardium masks using Dice-similarity-coefficient (DSC) and average symmetric surface distance (ASSD). For 10 pigs, we achieved a mean DSC of \(80.4\pm 7.8\)% and ASSD of \(1.28\pm 0.47\) mm for myocardium with a mean runtime of 1.5 min for each dataset. These results suggest that the developed approach provide the registration accuracy and computational efficiency that may be suitable for clinical applications of cardiac MRI that involve a cine and MCLE MRI registration component.


Multicontrast late enhancement MRI Myocardium infarct tissue characterization Image registration Convex optimization 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Sunnybrook Research InstituteUniversity of TorontoTorontoCanada
  2. 2.Department of Medical BiophysicsUniversity of TorontoTorontoCanada
  3. 3.Department of Biomedical EngineeringUniversity of TorontoTorontoCanada

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