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Dengue: An Expanding Neglected Tropical Disease

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Neglected Tropical Diseases - East Asia

Part of the book series: Neglected Tropical Diseases ((NTD))

Abstract

The World Health Origanization has classified dengue as a major international public health concern. The reasons for the resurgence are complex, and are likely a combination of multiple factors, including population growth associated with rapid uncontrolled urbanization, increased movement of viruses in people among countries and regions via international travel, demographic changes, poor vector control, genetic changes in circulating or introduced viruses, and modulating climatic factors. The past decade has seen more investment in vaccine development and novel vector control measures than ever before. Three dengue vaccine candidates are far advanced in development, with CYD-TDV being the first licensed dengue vaccine. However, this vaccine showed serostatus dependent performance. The two other dengue vaccines are currently in Phase 3 efficacy trials.

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References

  • Achee NL, Gould F, Perkins TA, Reiner RC Jr, Morrison AC, Ritchie SA, Gubler DJ, Teyssou R, Scott TW (2015) A critical assessment of vector control for dengue prevention. PLoS Negl Trop Dis 9:e0003655

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Adalja AA, Sell TK, Bouri N, Franco C (2012) Lessons learned during dengue outbreaks in the United States, 2001–2011. Emerg Infect Dis 18:608–614

    Article  PubMed  PubMed Central  Google Scholar 

  • Alphey L (2014) Genetic control of mosquitoes. Annu Rev Entomol 59:205–224

    Article  CAS  PubMed  Google Scholar 

  • Alphey L, Alphey N (2014) Five things to know about genetically modified (GM) insects for vector control. PLoS Pathog 10:e1003909

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Alves MJ, Fernandes PL, Amaro F, Osorio H, Luz T, Parreira P, Andrade G, Ze-Ze L, Zeller H (2013) Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira island, Portugal, October 2012. Euro Surveill 18

    Google Scholar 

  • Anderson KB, Gibbons RV, Cummings DA, Nisalak A, Green S, Libraty DH, Jarman RG, Srikiatkhachorn A, Mammen MP, Darunee B, Yoon IK, Endy TP (2014) A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand. J Infect Dis 209:360–368

    Article  CAS  PubMed  Google Scholar 

  • Andersson N, Nava-Aguilera E, Arostegui J, Morales-Perez A, Suazo-Laguna H, Legorreta-Soberanis J, Hernandez-Alvarez C, Fernandez-Salas I, Paredes-Solis S, Balmaseda A, Cortes-Guzman AJ, Serrano De Los Santos R, Coloma J, Ledogar RJ, Harris E (2015) Evidence based community mobilization for dengue prevention in Nicaragua and Mexico (Camino Verde, the Green Way): cluster randomized controlled trial. BMJ 351:h3267

    Article  PubMed  PubMed Central  Google Scholar 

  • Banu S, Hu W, Hurst C, Tong S (2011) Dengue transmission in the Asia-Pacific region: impact of climate change and socio-environmental factors. Trop Med Int Health 16:598–607

    Article  PubMed  Google Scholar 

  • Beaute J, Vong S (2010) Cost and disease burden of dengue in Cambodia. BMC Public Health 10:521

    Article  PubMed  PubMed Central  Google Scholar 

  • Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI (2013) The global distribution and burden of dengue. Nature 496:504–507

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bonet M, Spiegel JM, Ibarra AM, Kouri G, Pintre A, Yassi A (2007) An integrated ecosystem approach for sustainable prevention and control of dengue in Central Havana. Int J Occup Environ Health 13:188–194

    Article  PubMed  Google Scholar 

  • Bowman LR, Donegan S, Mccall PJ (2016) Is dengue vector control deficient in effectiveness or evidence?: systematic review and meta-analysis. PLoS Negl Trop Dis 10:e0004551

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Capeding MR, Tran NH, Hadinegoro SR, Ismail HI, Chotpitayasunondh T, Chua MN, Luong CQ, Rusmil K, Wirawan DN, Nallusamy R, Pitisuttithum P, Thisyakorn U, Yoon IK, van der Vliet D, Langevin E, Laot T, Hutagalung Y, Frago C, Boaz M, Wartel TA, Tornieporth NG, Saville M, Bouckenooghe A, CYD Study Group (2014) Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial. Lancet 384:1358–1365

    Article  CAS  PubMed  Google Scholar 

  • Carrasco LR, Lee LK, Lee VJ, Ooi EE, Shepard DS, Thein TL, Gan V, Cook AR, Lye D, Ng LC, Leo YS (2011) Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. PLoS Negl Trop Dis 5:e1426

    Article  PubMed  PubMed Central  Google Scholar 

  • Centers for Disease Control and Prevention (CDC) (1996) Dengue fever at the U.S.-Mexico border, 1995–1996. MMWR Morb Mortal Wkly Rep 45:841–844

    Google Scholar 

  • Cheng S, Kalkstein LS, Focks DA, Nnaji A (1998) New procedures to estimate water temperatures and water depths for application in climate-dengue modeling. J Med Entomol 35:646–652

    Article  CAS  PubMed  Google Scholar 

  • Cummings DA, Irizarry RA, Huang NE, Endy TP, Nisalak A, Ungchusak K, Burke DS (2004) Travelling waves in the occurrence of dengue haemorrhagic fever in Thailand. Nature 427:344–347

    Article  CAS  PubMed  Google Scholar 

  • Deraedt Banks S, Orsborne J, Gezan SA, Kaur H, Wilder-Smith A, Lindsey SW, Logan JG (2015) Permethrin-treated clothing as protection against the dengue vector, Aedes aegypti: extent and duration of protection. PLoS Negl Trop Dis 9:e0004109

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dorigatti I, Mccormack C, Nedjati-Gilani G, Ferguson NM (2017) Using Wolbachia for dengue control: insights from modelling. Trends Parasitol 34:102–113

    Article  PubMed  PubMed Central  Google Scholar 

  • Effler PV, Pang L, Kitsutani P, Vorndam V, Nakata M, Ayers T, Elm J, Tom T, Reiter P, Rigau-Perez JG, Hayes JM, Mills K, Napier M, Clark GG, Gubler DJ, Hawaii Dengue Outbreak Investigation T (2005) Dengue fever, Hawaii, 2001–2002. Emerg Infect Dis 11:742–749

    Article  PubMed  PubMed Central  Google Scholar 

  • Egger JR, Ooi EE, Kelly DW, Woolhouse ME, Davies CR, Coleman PG (2008) Reconstructing historical changes in the force of infection of dengue fever in Singapore: implications for surveillance and control. Bull World Health Organ 86:187–196

    Article  PubMed  Google Scholar 

  • Eisen L, Beaty BJ, Morrison AC, Scott TW (2009) Proactive vector control strategies and improved monitoring and evaluation practices for dengue prevention. J Med Entomol 46:1245–1255

    Article  PubMed  Google Scholar 

  • Endy TP, Anderson KB, Nisalak A, Yoon IK, Green S, Rothman AL, Thomas SJ, Jarman RG, Libraty DH, Gibbons RV (2011) Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis 5:e975

    Article  PubMed  PubMed Central  Google Scholar 

  • Frank C, Hohle M, Stark K, Lawrence J (2013) More reasons to dread rain on vacation? Dengue fever in 42 German and United Kingdom Madeira tourists during autumn 2012. Euro Surveill 18(14):20446

    Article  CAS  PubMed  Google Scholar 

  • Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA (2015) Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci USA 112:E6736–E6743

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gjenero-Margan I, Aleraj B, Krajcar D, Lesnikar V, Klobucar A, Pem-Novosel I, Kurecic-Filipovic S, Komparak S, Martic R, Duricic S, Betica-Radic L, Okmadzic J, Vilibic-Cavlek T, Babic-Erceg A, Turkovic B, Avsic-Zupanc T, Radic I, Ljubic M, Sarac K, Benic N, Mlinaric-Galinovic G (2011) Autochthonous dengue fever in Croatia, August-September 2010. Euro Surveill 16(9)

    Google Scholar 

  • Glaesser D, Kester J, Paulose H, Alizadeh A, Valentin B (2017) Global travel patterns: an overview. J Travel Med 24(4). https://doi.org/10.1093/jtm/tax007

  • Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, Fleming T, Forouzanfar MH, Hancock J, Hay RJ, Hunter-Merrill R, Huynh C, Hosgood HD, Johnson CO, Jonas JB, Khubchandani J, Kumar GA, Kutz M, Lan Q, Larson HJ, Liang X, Lim SS, Lopez AD, Macintyre MF, Marczak L, Marquez N, Mokdad AH, Pinho C, Pourmalek F, Salomon JA, Sanabria JR, Sandar L, Sartorius B, Schwartz SM, Shackelford KA, Shibuya K, Stanaway J, Steiner C, Sun J, Takahashi K, Vollset SE, Vos T, Wagner JA, Wang H, Westerman R, Zeeb H, Zoeckler L, Abd-Allah F, Ahmed MB, Alabed S, Alam NK, Aldhahri SF, Alem G, Alemayohu MA, Ali R, Al-Raddadi R, Amare A, Amoako Y, Artaman A, Asayesh H, Atnafu N, Awasthi A, Saleem HB, Barac A, Bedi N, Bensenor I, Berhane A, Bernabe E, Betsu B, Binagwaho A, Boneya D, Campos-Nonato I, Castaneda-Orjuela C, Catala-Lopez F, Chiang P, Chibueze C, Chitheer A, Choi JY, Cowie B, Damtew S, Das Neves J, Dey S, Dharmaratne S, Dhillon P, Ding E, Driscoll T, Ekwueme D, Endries AY, Farvid M, Farzadfar F, Fernandes J, Fischer F, G/Hiwot TT, Gebru A, Gopalani S et al (2017) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease Study. JAMA Oncol 3:524–548

    Article  PubMed Central  Google Scholar 

  • Gubler DJ (1989) Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up. Charles Franklin Craig Lecture. Am J Trop Med Hyg 40:571–578

    Article  CAS  PubMed  Google Scholar 

  • Gubler DJ (1998) Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11:480–496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gubler DJ (2011) Dengue, urbanization and globalization: the unholy trinity of the 21(st) century. Trop Med Health 39:3–11

    Article  PubMed  PubMed Central  Google Scholar 

  • Gubler DJ, Trent DW (1993) Emergence of epidemic dengue/dengue hemorrhagic fever as a public health problem in the Americas. Infect Agents Dis 2:383–393

    CAS  PubMed  Google Scholar 

  • Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martinez E, Nathan MB, Pelegrino JL, Simmons C, Yoksan S, Peeling RW (2010) Dengue: a continuing global threat. Nat Rev Microbiol 8:S7–S16

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hadinegoro SR, Arredondo-Garcia JL, Capeding MR, Deseda C, Chotpitayasunondh T, Dietze R, Ismail HI, Reynales H, Limkittikul K, Rivera-Medina DM, Tran HN, Bouckenooghe A, Chansinghakul D, Cortes M, Fanouillere K, Forrat R, Frago C, Gailhardou S, Jackson N, Noriega F, Plennevaux E, Wartel TA, Zambrano B, Saville M, Group C-TDVW (2015) Efficacy and long-term safety of a dengue vaccine in regions of endemic disease. N Engl J Med 373:1195–1206

    Article  CAS  PubMed  Google Scholar 

  • Hafkin B, Kaplan JE, Reed C, Elliott LB, Fontaine R, Sather GE, Kappus K (1982) Reintroduction of dengue fever into the continental United States. I. Dengue surveillance in Texas, 1980. Am J Trop Med Hyg 31:1222–1228

    Article  CAS  PubMed  Google Scholar 

  • Hales S, Weinstein P, Souares Y, Woodward A (1999) El Nino and the dynamics of vectorborne disease transmission. Environ Health Perspect 107:99–102

    CAS  PubMed  PubMed Central  Google Scholar 

  • Halstead SB (1988) Pathogenesis of dengue: challenges to molecular biology. Science 239:476–481

    Article  CAS  PubMed  Google Scholar 

  • Halstead SB, O’Rourke EJ (1977a) Antibody-enhanced dengue virus infection in primate leukocytes. Nature 265:739–741

    Article  CAS  PubMed  Google Scholar 

  • Halstead SB, O’Rourke EJ (1977b) Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med 146:201–217

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Halstead SB, Heinz FX, Barrett AD, Roehrig JT (2005) Dengue virus: molecular basis of cell entry and pathogenesis, 25–27 June 2003, Vienna, Austria. Vaccine 23:849–856

    Article  PubMed  Google Scholar 

  • Horstick O, Tozan Y, Wilder-Smith A (2015) Reviewing dengue: still a neglected tropical disease? PLoS Negl Trop Dis 9:e0003632

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kittayapong P, Olanratmanee P, Maskhao P, Byass P, Logan J, Tozan Y, Louis V, Gubler DJ, Wilder-Smith A (2017) Mitigating diseases transmitted by Aedes mosquitoes: a cluster-randomised trial of permethrin-impregnated school uniforms. PLoS Negl Trop Dis 11:e0005197

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kraemer MU, Sinka ME, Duda KA, Mylne AQ, Shearer FM, Barker CM, Moore CG, Carvalho RG, Coelho GE, Van Bortel W, Hendrickx G, Schaffner F, Elyazar IR, Teng HJ, Brady OJ, Messina JP, Pigott DM, Scott TW, Smith DL, Wint GR, Golding N, Hay SI (2015) The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus. Elife 4:e08347

    Article  PubMed  PubMed Central  Google Scholar 

  • La Ruche G, Souares Y, Armengaud A, Peloux-Petiot F, Delaunay P, Despres P, Lenglet A, Jourdain F, Leparc-Goffart I, Charlet F, Ollier L, Mantey K, Mollet T, Fournier JP, Torrents R, Leitmeyer K, Hilairet P, Zeller H, van Bortel W, Dejour-Salamanca D, Grandadam M, Gastellu-Etchegorry M (2010) First two autochthonous dengue virus infections in metropolitan France, September 2010. Euro Surveill 15:19676

    PubMed  Google Scholar 

  • Lambrechts L, Ferguson NM, Harris E, Holmes EC, Mcgraw EA, O’Neill SL, Ooi EE, Ritchie SA, Ryan PA, Scott TW, Simmons CP, Weaver SC (2015) Assessing the epidemiological effect of Wolbachia for dengue control. Lancet Infect Dis 15:862–866

    Article  PubMed  PubMed Central  Google Scholar 

  • Lazaro A, Han WW, Manrique-Saide P, George L, Velayudhan R, Toledo J, Runge Ranzinger S, Horstick O (2015) Community effectiveness of copepods for dengue vector control: systematic review. Trop Med Int Health 20:685–706

    Article  CAS  PubMed  Google Scholar 

  • Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JS, Schwartz E, Barnett ED, von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman DO (2013) GeoSentinel surveillance of illness in returned travelers, 2007–2011. Ann Intern Med 158:456–468

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee Han L, Vasan S, Birgelen L, Murtola T, Gong H, Field RW, Mavalankar DV, Ahmad NW, Hakim LS, Murad S, Ng Chiu W, Lucy Lum Chai S, Suaya JA, Shepard DS (2010) Immediate cost of dengue to Malaysia and Thailand: an estimate. Dengue Bull 34:65–76

    Google Scholar 

  • Lin CC, Huang YH, Shu PY, Wu HS, Lin YS, Yeh TM, Liu HS, Liu CC, Lei HY (2010) Characteristic of dengue disease in Taiwan: 2002–2007. Am J Trop Med Hyg 82:731–739

    Article  PubMed  PubMed Central  Google Scholar 

  • Louis VR, Phalkey R, Horstick O, Ratanawong P, Wilder-Smith A, Tozan Y, Dambach P (2014) Modeling tools for dengue risk mapping – a systematic review. Int J Health Geogr 13:50

    Article  PubMed  PubMed Central  Google Scholar 

  • Louis VR, Montenegro Quinonez CA, Kusumawathie P, Palihawadana P, Janaki S, Tozan Y, Wijemuni R, Wilder-Smith A, Tissera HA (2016) Characteristics of and factors associated with dengue vector breeding sites in the City of Colombo, Sri Lanka. Pathog Glob Health 110:79–86

    Article  PubMed  PubMed Central  Google Scholar 

  • Low JG, Sung C, Wijaya L, Wei Y, Rathore AP, Watanabe S, Tan BH, Toh L, Chua LT, Hou Y, Chow A, Howe S, Chan WK, Tan KH, Chung JS, Cherng BP, Lye DC, Tambayah PA, Ng LC, Connolly J, Hibberd ML, Leo YS, Cheung YB, Ooi EE, Vasudevan SG (2014) Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet Infect Dis 14:706–715

    Article  CAS  PubMed  Google Scholar 

  • Maciel-De-Freitas R, Avendanho FC, Santos R, Sylvestre G, Araujo SC, Lima JB, Martins AJ, Coelho GE, Valle D (2014) Undesirable consequences of insecticide resistance following Aedes aegypti control activities due to a dengue outbreak. PLoS One 9:e92424

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Massad E, Rocklov J, Wilder-Smith A (2013) Dengue infections in non-immune travellers to Thailand. Epidemiol Infect 141:412–417

    Article  CAS  PubMed  Google Scholar 

  • Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, Duda KA, Bhatt S, Katzelnick L, Howes RE, Battle KE, Simmons CP, Hay SI (2014) Global spread of dengue virus types: mapping the 70 year history. Trends Microbiol 22:138–146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murray NE, Quam MB, Wilder-Smith A (2013) Epidemiology of dengue: past, present and future prospects. Clin Epidemiol 5:299–309

    PubMed  PubMed Central  Google Scholar 

  • Ooi E, Gubler D (2009a) Global spread of epidemic dengue: the influence of environmental change. Future Virol 4:571–580

    Article  Google Scholar 

  • Ooi EE, Gubler DJ (2009b) Dengue in Southeast Asia: epidemiological characteristics and strategic challenges in disease prevention. Cad Saude Publica 25(Suppl 1):S115–S124

    Article  PubMed  Google Scholar 

  • Ooi EE, Goh KT, Gubler DJ (2006) Dengue prevention and 35 years of vector control in Singapore. Emerg Infect Dis 12:887–893

    Article  PubMed  PubMed Central  Google Scholar 

  • Orsborne J, Deraedt Banks S, Hendy A, Gezan SA, Kaur H, Wilder-Smith A, Lindsay SW, Logan JG (2016) Personal protection of permethrin-treated clothing against Aedes aegypti, the vector of dengue and Zika virus, in the laboratory. PLoS One 11:e0152805

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Park JH, Lee DW (2012) Dengue fever in South Korea, 2006–2010. Emerg Infect Dis 18:1525–1527

    Article  PubMed  PubMed Central  Google Scholar 

  • Peeling RW, Artsob H, Pelegrino JL, Buchy P, Cardosa MJ, Devi S, Enria DA, Farrar J, Gubler DJ, Guzman MG, Halstead SB, Hunsperger E, Kliks S, Margolis HS, Nathanson CM, Nguyen VC, Rizzo N, Vazquez S, Yoksan S (2010) Evaluation of diagnostic tests: dengue. Nat Rev Microbiol 8:S30–S38

    Article  CAS  PubMed  Google Scholar 

  • Quam MB, Wilder-Smith A (2015) Importation index of dengue to determine the most probable origin of importation. J Travel Med 22:72

    Article  PubMed  Google Scholar 

  • Quam MB, Khan K, Sears J, Hu W, Rocklov J, Wilder-Smith A (2015) Estimating air travel-associated importations of dengue virus into Italy. J Travel Med 22:186–193

    Article  PubMed  Google Scholar 

  • Quam MB, Sessions O, Kamaraj US, Rocklov J, Wilder-Smith A (2016) Dissecting Japan’s dengue outbreak in 2014. Am J Trop Med Hyg 94:409–412

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Reiner RC Jr, Achee N, Barrera R, Burkot TR, Chadee DD, Devine GJ, Endy T, Gubler D, Hombach J, Kleinschmidt I, Lenhart A, Lindsay SW, Longini I, Mondy M, Morrison AC, Perkins TA, Vazquez-Prokopec G, Reiter P, Ritchie SA, Smith DL, Strickman D, Scott TW (2016) Quantifying the epidemiological impact of vector control on dengue. PLoS Negl Trop Dis 10:e0004588

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Reiter P (1998) Aedes albopictus and the world trade in used tires, 1988–1995: the shape of things to come? J Am Mosq Control Assoc 14:83–94

    CAS  PubMed  Google Scholar 

  • Rico-Hesse R (2003) Microevolution and virulence of dengue viruses. Adv Virus Res 59:315–341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ritchie SA, Devine GJ (2013) Confusion, knock-down and kill of Aedes aegypti using metofluthrin in domestic settings: a powerful tool to prevent dengue transmission? Parasit Vectors 6:262

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rocklov J, Quam MB, Sudre B, German M, Kraemer MU, Brady O, Bogoch II, Liu-Helmersson J, Wilder-Smith A, Semenza JC, Ong M, Aaslav KK, Khan K (2016) Assessing seasonal risks for the introduction and mosquito-borne spread of Zika virus in Europe. EBioMedicine 9:250–256

    Article  PubMed  PubMed Central  Google Scholar 

  • Runge-Ranzinger S, Horstick O, Marx M, Kroeger A (2008) What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? Trop Med Int Health 13:1022–1041

    Article  PubMed  Google Scholar 

  • Runge-Ranzinger S, Mccall PJ, Kroeger A, Horstick O (2014) Dengue disease surveillance: an updated systematic literature review. Trop Med Int Health 19:1116–1160

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Runge-Ranzinger S, Kroeger A, Olliaro P, Mccall PJ, Sanchez Tejeda G, Lloyd LS, Hakim L, Bowman LR, Horstick O, Coelho G (2016) Dengue contingency planning: from research to policy and practice. PLoS Negl Trop Dis 10:e0004916

    Article  PubMed  PubMed Central  Google Scholar 

  • Sang S, Yin W, Bi P, Zhang H, Wang C, Liu X, Chen B, Yang W, Liu Q (2014) Predicting local dengue transmission in Guangzhou, China, through the influence of imported cases, mosquito density and climate variability. PLoS One 9:e102755

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schwartz E, Weld LH, Wilder-Smith A, Von Sonnenburg F, Keystone JS, Kain KC, Torresi J, Freedman DO (2008) Seasonality, annual trends, and characteristics of dengue among ill returned travelers, 1997–2006. Emerg Infect Dis 14:1081–1088

    Article  PubMed  PubMed Central  Google Scholar 

  • Schwartz E, Meltzer E, Mendelson M, Tooke A, Steiner F, Gautret P, Friedrich-Jaenicke B, Libman M, Bin H, Wilder-Smith A, Gubler D, Freedman DO, Parola P (2013) Detection on four continents of dengue fever cases related to an ongoing outbreak in Luanda, Angola, March to May 2013. Euro Surveill 18

    Google Scholar 

  • Sessions OM, Khan K, Hou Y, Meltzer E, Quam M, Schwartz E, Gubler DJ, Wilder-Smith A (2013) Exploring the origin and potential for spread of the 2013 dengue outbreak in Luanda, Angola. Glob Health Action 6:21822

    Article  PubMed  Google Scholar 

  • Shang CS, Fang CT, Liu CM, Wen TH, Tsai KH, King CC (2010) The role of imported cases and favorable meteorological conditions in the onset of dengue epidemics. PLoS Negl Trop Dis 4:e775

    Article  PubMed  PubMed Central  Google Scholar 

  • Shepard DS, Undurraga EA, Halasa YA (2013) Economic and disease burden of dengue in Southeast Asia. PLoS Negl Trop Dis 7:e2055

    Article  PubMed  PubMed Central  Google Scholar 

  • Shepard DS, Halasa YA, Tyagi BK, Adhish SV, Nandan D, Karthiga KS, Chellaswamy V, Gaba M, Arora NK, The ISG (2014) Economic and disease burden of dengue illness in India. Am J Trop Med Hyg 91:1235–1242

    Article  PubMed  PubMed Central  Google Scholar 

  • Simmons CP, Farrar JJ, Nguyen V, Wills B (2012) Dengue. N Engl J Med 366:1423–1432

    Article  CAS  PubMed  Google Scholar 

  • Sinkins SP, Braig HR, O’Neill SL (1995) Wolbachia superinfections and the expression of cytoplasmic incompatibility. Proc Biol Sci 261:325–330

    Article  CAS  PubMed  Google Scholar 

  • Sousa CA, Clairouin M, Seixas G, Viveiros B, Novo MT, Silva AC, Escoval MT, Economopoulou A (2012) Ongoing outbreak of dengue type 1 in the autonomous region of Madeira, Portugal: preliminary report. Euro Surveill 17

    Google Scholar 

  • Struchiner CJ, Rocklov J, Wilder-Smith A, Massad E (2015) Increasing dengue incidence in Singapore over the past 40 years: population growth, climate and mobility. PLoS One 10:e0136286

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Suaya JA, Shepard DS, Siqueira JB, Martelli CT, Lum LC, Tan LH, Kongsin S, Jiamton S, Garrido F, Montoya R, Armien B, Huy R, Castillo L, Caram M, Sah BK, Sughayyar R, Tyo KR, Halstead SB (2009) Cost of dengue cases in eight countries in the Americas and Asia: a prospective study. Am J Trop Med Hyg 80:846–855

    Article  PubMed  Google Scholar 

  • Takasaki T (2011) Imported dengue fever/dengue hemorrhagic fever cases in Japan. Trop Med Health 39:13–15

    Article  PubMed  PubMed Central  Google Scholar 

  • Tatem AJ, Huang Z, Das A, Qi Q, Roth J, Qiu Y (2012) Air travel and vector-borne disease movement. Parasitology 139:1816–1830

    Article  CAS  PubMed  Google Scholar 

  • Thalagala N, Tissera H, Palihawadana P, Amarasinghe A, Ambagahawita A, Wilder-Smith A, Shepard DS, Tozan Y (2016) Costs of dengue control activities and hospitalizations in the public health sector during an epidemic year in urban Sri Lanka. PLoS Negl Trop Dis 10:e0004466

    Article  PubMed  PubMed Central  Google Scholar 

  • The BioDiaspora Project [Online]. Toronto. http://www.biodiaspora.com. Accessed 24 Apr 2013

  • Tissera H, Amarasinghe A, de Silva AD, Kariyawasam P, Corbett KS, Katzelnick L, Tam C, Letson GW, Margolis HS, de Silva AM (2014) Burden of dengue infection and disease in a pediatric cohort in urban Sri Lanka. Am J Trop Med Hyg 91:132–137

    Article  PubMed  PubMed Central  Google Scholar 

  • Tissera H, Amarasinghe A, Gunasena S, Desilva AD, Yee LW, Sessions O, Muthukuda C, Palihawadana P, Lohr W, Byass P, Gubler DJ, Wilder-Smith A (2016) Laboratory-enhanced dengue sentinel surveillance in Colombo District, Sri Lanka: 2012-2014. PLoS Negl Trop Dis 10:e0004477

    Article  PubMed  PubMed Central  Google Scholar 

  • Vannice KS, Roehrig JT, Hombach J (2015) Next generation dengue vaccines: a review of the preclinical development pipeline. Vaccine 33:7091–7099

    Article  PubMed  Google Scholar 

  • Villar L, Dayan GH, Arredondo-Garcia JL, Rivera DM, Cunha R, Deseda C, Reynales H, Costa MS, Morales-Ramirez JO, Carrasquilla G, Rey LC, Dietze R, Luz K, Rivas E, Miranda Montoya MC, Cortes Supelano M, Zambrano B, Langevin E, Boaz M, Tornieporth N, Saville M, Noriega F, CYD Study Group (2015) Efficacy of a tetravalent dengue vaccine in children in Latin America. N Engl J Med 372:113–123

    Article  PubMed  CAS  Google Scholar 

  • Wang E, Ni H, Xu R, Barrett AD, Watowich SJ, Gubler DJ, Weaver SC (2000) Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. J Virol 74:3227–3234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Whitehead S (2016) Development of TV003/TV005, a single dose, highly immunogenic live attenuated dengue vaccine; what makes this vaccine different? Expert Rev Vaccines 15(4):509–517

    Google Scholar 

  • WHO (2012) Global strategy for dengue prevention and control, 2012–2020. WHO Press, Geneva

    Google Scholar 

  • Wilder-Smith A (2017) Moving forward with Takeda’s live chimeric tetravalent dengue vaccine. Lancet Infect Dis 17:566–568

    Article  PubMed  Google Scholar 

  • Wilder-Smith A, Gubler DJ (2008) Geographic expansion of dengue: the impact of international travel. Med Clin North Am 92:1377–1390

    Article  PubMed  Google Scholar 

  • Wilder-Smith A, Macary P (2014) Dengue: challenges for policy makers and vaccine developers. Curr Infect Dis Rep 16:404

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilder-Smith A, Schwartz E (2005) Dengue in travelers. N Engl J Med 353:924–932

    Article  CAS  PubMed  Google Scholar 

  • Wilder-Smith A, Ooi EE, Vasudevan SG, Gubler DJ (2010) Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development. Curr Infect Dis Rep 12:157–164

    Article  PubMed  Google Scholar 

  • Wilder-Smith A, Renhorn KE, Tissera H, Abu Bakar S, Alphey L, Kittayapong P, Lindsay S, Logan J, Hatz C, Reiter P, Rocklov J, Byass P, Louis VR, Tozan Y, Massad E, Tenorio A, Lagneau C, L’Ambert G, Brooks D, Wegerdt J, Gubler D (2012) DengueTools: innovative tools and strategies for the surveillance and control of dengue. Glob Health Action 5. https://doi.org/10.3402/gha.v5i0.17273

    Article  Google Scholar 

  • Wilder-Smith A, Cohn E, Lloyd DC, Tozan Y, Brownstein JS (2016a) Internet-based media coverage on dengue in Sri Lanka between 2007 and 2015. Glob Health Action 9:31620

    Article  PubMed  Google Scholar 

  • Wilder-Smith A, Vannice KS, Hombach J, Farrar J, Nolan T (2016b) Population perspectives and World Health Organization recommendations for CYD-TDV dengue vaccine. J Infect Dis 214:1796–1799

    Article  PubMed  Google Scholar 

  • Wilder-Smith A, Gubler DJ, Weaver SC, Monath TP, Heymann DL, Scott TW (2017) Epidemic arboviral diseases: priorities for research and public health. Lancet Infect Dis 17:e101–e106

    Article  PubMed  Google Scholar 

  • Wilson ME, Weld LH, Boggild A, Keystone JS, Kain KC, von Sonnenburg F, Schwartz E (2007) Fever in returned travelers: results from the GeoSentinel Surveillance Network. Clin Infect Dis 44:1560–1568

    Article  PubMed  Google Scholar 

  • World Health Organization. http://www.who.int/entity/immunization/sage/meetings/2016/april/1_Background_Paper_Dengue_Vaccines_2016_03_17.pdf?ua=1. Accessed 22 July 2016

  • Wu JY, Lun ZR, James AA, Chen XG (2010) Dengue fever in mainland China. Am J Trop Med Hyg 83:664–671

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu HH, Wang CY, Teng HJ, Lin C, Lu LC, Jian SW, Chang NT, Wen TH, Wu JW, Liu DP, Lin LJ, Norris DE, Wu HS (2013) A dengue vector surveillance by human population-stratified ovitrap survey for Aedes (Diptera: Culicidae) adult and egg collections in high dengue-risk areas of Taiwan. J Med Entomol 50:261–269

    Article  PubMed  Google Scholar 

  • Yakob L, Funk S, Camacho A, Brady O, Edmunds WJ (2017) Aedes aegypti control through modernized, integrated vector management. PLoS Curr 9

    Google Scholar 

  • Yang CF, Hou JN, Chen TH, Chen WJ (2013) Discriminable roles of Aedes aegypti and Aedes albopictus in establishment of dengue outbreaks in Taiwan. Acta Trop 130C:17–23

    Google Scholar 

  • Zhang FC, Zhao H, Li LH, Jiang T, Hong WX, Wang J, Zhao LZ, Yang HQ, Ma DH, Bai CH, Shan XY, Deng YQ, Qin CF (2014) Severe dengue outbreak in Yunnan, China, 2013. Int J Infect Dis 27:4–6

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

    Annelies Wilder-Smith & Eng Eong Ooi

  2. Duke-NUS Graduate Medical School, Singapore, Singapore

    Tanu Chawla

Authors
  1. Annelies Wilder-Smith
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  2. Tanu Chawla
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  3. Eng Eong Ooi
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Correspondence to Annelies Wilder-Smith .

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Editors and Affiliations

  1. Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland

    Jürg Utzinger

  2. Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore

    Peiling Yap

  3. Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland

    Martin Bratschi

  4. Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland

    Peter Steinmann

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Wilder-Smith, A., Chawla, T., Ooi, E.E. (2019). Dengue: An Expanding Neglected Tropical Disease. In: Utzinger, J., Yap, P., Bratschi, M., Steinmann, P. (eds) Neglected Tropical Diseases - East Asia. Neglected Tropical Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-12008-5_4

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