Abstract
The presence of lymphoid follicles in a skin biopsy is always a pathologic finding. Unlike tonsils and lymph nodes, they are not native to the skin. Several skin conditions may demonstrate lymphoid follicles, including reactive lymphoid hyperplasia, cutaneous Rosai-Dorfman disease, cutaneous IgG4-related disease, and lupus panniculitis. In addition, lymphoid follicles are identified in low-grade cutaneous B-cell lymphomas (marginal zone lymphoma and follicle center lymphoma).
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LeBlanc RE, Tavallaee M, Kim YH, et al. Useful parameters for distinguishing subcutaneous panniculitis-like T-cell lymphoma from lupus erythematosus panniculitis. Am J Surg Pathol. 2016 Jun;40(6):745–54.
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Subtil A. A general approach to the diagnosis of cutaneous lymphomas and pseudolymphomas. Cutaneous lymphomas (Subtil, ed.). Surg Pathol Clin. 2014;7(2):135–42. Elsevier: Philadelphia.
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Subtil, A. (2019). Differential Diagnosis of Lymphoid Follicle Formation. In: Diagnosis of Cutaneous Lymphoid Infiltrates. Springer, Cham. https://doi.org/10.1007/978-3-030-11654-5_11
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DOI: https://doi.org/10.1007/978-3-030-11654-5_11
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