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Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization pp 193–212Cite as

Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering

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Abstract

Liposomes and supported lipid bilayers (SLBs) are having an increasing impact in designing new biomedical approaches owing to their cell-like structures and native biophysical environment. In particular, as membrane proteins are target of 60–70% of pharmaceutical drugs in the research and industry, liposomes and SLBs denote unique and versatile capabilities in membrane protein research compared to the conventional systems, which have significant challenges in handling membrane proteins without denaturation and loss of function. Besides, the integrations of liposomes and SLBs into micro- and nano-array format open new avenues to create biochip strategies for modern clinical use. In this chapter, we extensively review biomedical applications of liposomes and SLBs through (i) sensing strategy for diagnostics and (ii) theranostics and labelling capability for imaging, (iii) carrier roles for vaccines, and (iv) tissue engineering approaches for multiple cellular processes. Integrated strategies such as lithography and array formation will be also discussed here in order to envision the potential applications of liposomes and SLBs in the near future.

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Authors and Affiliations

  1. Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey

    M. Özgen Öztürk Öncel & Bora Garipcan

  2. Department of Radiology, Stanford University, School of Medicine, Canary Center at Stanford for Cancer Early Detection, Palo Alto, CA, USA

    Fatih Inci

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  1. M. Özgen Öztürk Öncel
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  2. Bora Garipcan
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  3. Fatih Inci
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Correspondence to Bora Garipcan or Fatih Inci .

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Editors and Affiliations

  1. Department of Molecular Biology and Genetics, İstanbul Technical University, Istanbul, Turkey

    Fatma N. Kök

  2. Department of Bioengineering, Izmir Institute of Technology, Urla, Izmir, Turkey

    Ahu Arslan Yildiz

  3. School of Medicine, Stanford University, Palo Alto, CA, USA

    Fatih Inci

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Öztürk Öncel, M.Ö., Garipcan, B., Inci, F. (2019). Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering. In: Kök, F., Arslan Yildiz, A., Inci, F. (eds) Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization. Springer, Cham. https://doi.org/10.1007/978-3-030-11596-8_8

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