Abstract
The improvement in medical imaging technologies has increased demand for automated diagnosis methodologies. In this paper, we propose a method for automated diagnosis of schizophrenia based on features extracted from segmented boundaries of the lateral projection of MRI images of the corpus callosum.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
U.S. Department of Health and National Institute of Mental Health Human Services, National Institutes of Health, Nimh schizophrenia. https://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml. Accessed May 2017
M. Gheiratmand, I. Rish, G.A. Cecchi, M.R.G. Brown, R. Greiner, P.I. Polosecki, P. Bashivan, A.J. Greenshaw, R. Ramasubbu, S.M. Dursun, Learning stable and predictive network-based patterns of schizophrenia and its clinical symptoms. Schizophrenia 3, 22 (2017)
J.R. Highley, M.M. Esiri, B. McDonald, M. Cortina-Borja, B.M. Herron, T.J. Crow, The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study. Brain 122, 99–110 (1999)
P. Thompson, K. Narr, R. Blanton, A. Toga, Mapping structural alterations of the corpus callosum during brain development and degeneration, in The Parallel Brain: The Cognitive Neuroscience of the Corpus Callosum (MIT Press, Cambridge MA, 2003), pp. 93–130
J. Clarke, E. Zaidel, Anatomical-behavioral relationships: corpus callosum morphometry and hemispheric specialization. Behav. Brain Res. 64(1–2), 185–202 (1994)
J. Rajapakse, J. Giedd, J. Rumsey, A. Vaituzis, S. Hamburger, J. Rapoport, Regional MRI measurements of the corpus callosum: a methodological and developmental study. Brain Dev. 18(5), 379–388 (1996)
S. Witelson, Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain 112(3), 799–3835 (1996)
E. Luders, P. Thompson, K. Narr, A. Zamanyan, Y. Chou, B. Gutman, I. Dinov, A. Toga, The link between callosal thickness and intelligence in healthy children and adolescents. Neuroimage 54, 1823–1830 (2011)
S. Joshi, K.L.H. Narr, O.R. Philips, K.H. Nuechterlein, R.F. Asarnow, A.W. Toga, R.P. Woods, Statistical shape analysis of the corpus callosum in schizophrenia. NeuroImage 64, 547–559 (2013)
C.Y. Wan, G. Schlaug, Music making as a tool for promoting brain plasticity across the life span. Neuroscientist 16, 566–577 (2010)
H. Blum, A transformation for extracting new descriptors of shape, in Models for the Perception of Speech and Visual Form, ed. by W. Whaten-Dunn (MIT Press, Cambridge MA, 1967), pp. 362–380
P.J. Giblin, B.B. Kimia, On the local form and transitions of symmetry sets, medial axes, and shocks. Int. J. Comput. Vis. 54(1–3), 143–157 (2003)
K. Leonard, Efficient shape modeling: epsilon-entropy, adaptive coding, and boundary curves -vs- Blum’s medial axis. Int. J. Comput. Vis. 74(2), 183–199 (2007)
T.K. Dey, W. Zhao, Approximating the medial axis from the Voronoi diagram with a convergence guarantee. Algorithmica 38(1), 179–200 (2003)
L. Liu, E.W. Chambers, D. Letscher, T. Ju, Extended grassfire transform on medial axes of 2d shapes. Comput. Aided Des. 43(11), 1496–1505 (2011)
Acknowledgements
The authors would like to thank Shantanu Joshi and Katherine Narr at UCLA for the data and the problem. NSF IIS-0954256 provided support during the initial phase of this project. Finally, we would like to thank the Association for Women in Mathematics and NSF (NSF-HRD 1500481) and ICERM for supporting the Women in the Science of Mathematics and Data collaboration workshop.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 The Author(s) and the Association for Women in Mathematics
About this chapter
Cite this chapter
Aroutiounian, R., Leonard, K., Moreno, R., Teufel, R. (2019). Geometry-Based Classification for Automated Schizophrenia Diagnosis. In: Gasparovic, E., Domeniconi, C. (eds) Research in Data Science. Association for Women in Mathematics Series, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-030-11566-1_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-11566-1_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-11565-4
Online ISBN: 978-3-030-11566-1
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)