Abstract
Hodgkin lymphoma comprises two morphologically and immunophenotypically distinct entities - nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and classic Hodgkin lymphoma (CHL). Nodular lymphocyte-predominant Hodgkin lymphoma is infrequent and indolent B-cell neoplasm which accounts for less than 10% of Hodgkin lymphoma cases. It most commonly occurs in people 30-50 years of age and has a slight male predominance. Malignant cells in NLPHL are called lymphocyte predominant (LP) cells. Classic Hodgkin lymphoma is characterized by a small number of lymphoma cells (Hodgkin and Reed-Sternberg cells) in a non-neoplastic, inflammatory background. Four morphologic variants of CHL are recognized – nodular sclerosis, lymphocyte-rich, mixed cellularity, and lymphocyte depleted. Nodular sclerosis is by far the most common subtype (70%), followed by mixed cellularity.
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Nasr, M.R., Perry, A.M., Skrabek, P. (2019). Hodgkin Lymphomas. In: Lymph Node Pathology for Clinicians. Pathology for Clinicians. Springer, Cham. https://doi.org/10.1007/978-3-030-11515-9_7
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DOI: https://doi.org/10.1007/978-3-030-11515-9_7
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