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Biomarkers in Inflammatory Bowel Diseases pp 303–312Cite as

Metabolic Profiling in IBD

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Abstract

Metabolites are small molecules derived from biochemical processes in metabolism, and their profiling enables the analysis of physiological functions. Metabolic profiling through cross-sectional studies has moved forward to longitudinal cohort studies and metabolome-wide association studies (MWAS) which have helped unveil numerous discoveries in amino acid, fatty acid and energy metabolism pathways and their link in inflammatory bowel disease (IBD). This chapter will introduce metabolic profiling approaches and discuss the role that the metabolites play in the link between the gut microbiome and the host with regard to IBD. We will discuss the various biomarkers, which have been uncovered by metabonomics currently through separation of IBD phenotypes and the future for this area in relation to biomarkers for pathogenesis of IBD and personalizing medical therapy.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Surgery and Cancer, Imperial College, London, UK

    Maria Glymenaki, Jia V. Li & Julian R. Marchesi

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  1. Maria Glymenaki
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  2. Jia V. Li
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  3. Julian R. Marchesi
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Correspondence to Maria Glymenaki .

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Editors and Affiliations

  1. St Vincent’s Hospital, The University of Melbourne, Melbourne, VIC, Australia

    Nik Sheng Ding

  2. Austin Health, The University of Melbourne, Melbourne, VIC, Australia

    Peter De Cruz

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Glymenaki, M., Li, J.V., Marchesi, J.R. (2019). Metabolic Profiling in IBD. In: Sheng Ding, N., De Cruz, P. (eds) Biomarkers in Inflammatory Bowel Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-11446-6_25

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  • DOI: https://doi.org/10.1007/978-3-030-11446-6_25

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