Abstract
The primary function of the epididymis is to provide a conduit for the transport of sperm and seminiferous fluid from the rete testis to the vas deferens, but the epididymis also performs much more elaborate functions, including the resorption of some of the fluid by the head of the epididymis, final maturation and development of motility in the body, and storage of sperm in the tail. Performance of these functions requires the development of an elaborate rostral-to-caudal gradient of epithelial specialization from the efferent ductules to the beginning of the vas deferens, which is not completed until puberty. Knowledge of the changing fetal histology described in this chapter aids in the understanding of the congenital anomalies of the epididymis that are seen in association with cryptorchidism, renal and ureteral anomalies, cystic fibrosis, and other underlying conditions.
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References
De Miguel MP, Mariño JM, Gonzalez-Peramato P, Nistal M, Regadera J. Epididymal growth and differentiation are altered in human cryptorchidism. J Androl. 2001;22:212–25.
Felix W. The development of the urinogenital organs. In: Keibel F, Mall FP, editors. Human embryology. Philadelphia: JB Lippincott; 1912. p. 752–979.
Hadziselimovic F. Cryptorchidism. Berlin: Springer-Verlag; 1983.
Hadziselimovic F, Kruslin E. The role of the epididymis in descensus testis and the topographical relationship between the testis and epididymis from the sixth month of pregnancy until immediately after birth. Anat Embryol (Berl). 1979;155:191–6.
Dacheux JL, Belghazi M, Lanson Y, Dacheux F. Human epididymal secretome and proteome. Mol Cell Endocrinol. 2006;250:36–42.
Yeung CH, Cooper TG, Bergmann M, Schulze H. Organization of tubules in the human caput epididymidis and the ultrastructure of their epithelia. Am J Anat. 1991;191:261–79.
Trainer T. The testis and excretory duct system. In: Mills SE, editor. Histology for pathologists. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 943–63.
Ladman A. The male reproductive system. In: Greep RO, Weiss L, editors. Histology. 3rd ed. New York: McGraw-Hill; 1973. p. 847–90.
Nistal M, Gonzalez-Peramato P, De Miguel MP. Immunodetection of inhibin in the human testis and epididymis during normal development and in non-tumoural testicular lesions. Reprod Fertil Dev. 2010;22:558–63.
Shapiro E, Huang H, Masch RJ, McFadden DE, Wu XR, Ostrer H. Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis. J Urol. 2005;174:1695–8; discussion 1698
Regadera J, Cobo P, Paniagua R, Martínez-García F, Palacios J, Nistal M. Immunohistochemical and semiquantitative study of the apical mitochondria-rich cells of the human prepubertal and adult epididymis. J Anat. 1993;183:507–14.
Joseph A, Yao H, Hinton BT. Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns. Dev Biol. 2009;325:6–14.
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Huff, D.S., Ruchelli, E.D. (2019). Epididymis. In: Ernst, L., Ruchelli, E., Carreon, C., Huff, D. (eds) Color Atlas of Human Fetal and Neonatal Histology. Springer, Cham. https://doi.org/10.1007/978-3-030-11425-1_11
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DOI: https://doi.org/10.1007/978-3-030-11425-1_11
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