Skip to main content

Abstract

The primary function of the epididymis is to provide a conduit for the transport of sperm and seminiferous fluid from the rete testis to the vas deferens, but the epididymis also performs much more elaborate functions, including the resorption of some of the fluid by the head of the epididymis, final maturation and development of motility in the body, and storage of sperm in the tail. Performance of these functions requires the development of an elaborate rostral-to-caudal gradient of epithelial specialization from the efferent ductules to the beginning of the vas deferens, which is not completed until puberty. Knowledge of the changing fetal histology described in this chapter aids in the understanding of the congenital anomalies of the epididymis that are seen in association with cryptorchidism, renal and ureteral anomalies, cystic fibrosis, and other underlying conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. De Miguel MP, Mariño JM, Gonzalez-Peramato P, Nistal M, Regadera J. Epididymal growth and differentiation are altered in human cryptorchidism. J Androl. 2001;22:212–25.

    PubMed  Google Scholar 

  2. Felix W. The development of the urinogenital organs. In: Keibel F, Mall FP, editors. Human embryology. Philadelphia: JB Lippincott; 1912. p. 752–979.

    Google Scholar 

  3. Hadziselimovic F. Cryptorchidism. Berlin: Springer-Verlag; 1983.

    Book  Google Scholar 

  4. Hadziselimovic F, Kruslin E. The role of the epididymis in descensus testis and the topographical relationship between the testis and epididymis from the sixth month of pregnancy until immediately after birth. Anat Embryol (Berl). 1979;155:191–6.

    Article  CAS  Google Scholar 

  5. Dacheux JL, Belghazi M, Lanson Y, Dacheux F. Human epididymal secretome and proteome. Mol Cell Endocrinol. 2006;250:36–42.

    Article  CAS  Google Scholar 

  6. Yeung CH, Cooper TG, Bergmann M, Schulze H. Organization of tubules in the human caput epididymidis and the ultrastructure of their epithelia. Am J Anat. 1991;191:261–79.

    Article  CAS  Google Scholar 

  7. Trainer T. The testis and excretory duct system. In: Mills SE, editor. Histology for pathologists. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 943–63.

    Google Scholar 

  8. Ladman A. The male reproductive system. In: Greep RO, Weiss L, editors. Histology. 3rd ed. New York: McGraw-Hill; 1973. p. 847–90.

    Google Scholar 

  9. Nistal M, Gonzalez-Peramato P, De Miguel MP. Immunodetection of inhibin in the human testis and epididymis during normal development and in non-tumoural testicular lesions. Reprod Fertil Dev. 2010;22:558–63.

    Article  CAS  Google Scholar 

  10. Shapiro E, Huang H, Masch RJ, McFadden DE, Wu XR, Ostrer H. Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis. J Urol. 2005;174:1695–8; discussion 1698

    Article  CAS  Google Scholar 

  11. Regadera J, Cobo P, Paniagua R, Martínez-García F, Palacios J, Nistal M. Immunohistochemical and semiquantitative study of the apical mitochondria-rich cells of the human prepubertal and adult epididymis. J Anat. 1993;183:507–14.

    PubMed  PubMed Central  Google Scholar 

  12. Joseph A, Yao H, Hinton BT. Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns. Dev Biol. 2009;325:6–14.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eduardo D. Ruchelli .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Huff, D.S., Ruchelli, E.D. (2019). Epididymis. In: Ernst, L., Ruchelli, E., Carreon, C., Huff, D. (eds) Color Atlas of Human Fetal and Neonatal Histology. Springer, Cham. https://doi.org/10.1007/978-3-030-11425-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-11425-1_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11424-4

  • Online ISBN: 978-3-030-11425-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics