Skip to main content

Glucose, Insulin, and Inner Ear Pathology

  • Chapter
  • First Online:
The New Neurotology

Abstract

The inner ear has highly complex metabolic mechanisms. The maintenance of the endocochlear potential and of the chemical composition of endolymph is highly dependent on oxygen and glucose. This chapter discusses two mechanisms of reactive hypoglycemia that cause cochlear and vestibular symptoms. The inner ears are very sensitive organs and in many patients are the first to show signs of carbohydrate metabolism disorders. The cochlear and vestibular symptoms resulting from these disorders are very common, can be diagnosed and treated, and are often reversible.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mangabeira-Albernaz PL, Covell WP. Acoustic trauma lesions by fluorescence microscopy. Laryngoscope. 1962;72:1278–96.

    Google Scholar 

  2. Thalmann R, Matschinsky FM, Thalmann R. Quantitative study of selected enzymes involved in energy metabolism of the cochlear duct. Ann Otol Rhinol Laryngol. 1970;79:12–29.

    Article  CAS  Google Scholar 

  3. Degerman E, Rauch U, Lindberg S, Caye-Thomasen P, Hultgårdh A, Magnusson M. Expression of insulin signalling components in the sensory epithelium of the human saccule. Cell Tissue Res. 2013;352(3):469–78. https://doi.org/10.1007/s00441-013-1614-x.

    Article  CAS  PubMed  Google Scholar 

  4. Fernandez C. The effect of oxygen lack on cochlear potentials. Ann Otol Rhinol Laryngol. 1955;64:1193–203.

    Article  CAS  Google Scholar 

  5. Tsunoo M, Perlman HB. Respiration of the cochlea and function. Acta Otolaryngol. 1969;67:17–23.

    Article  CAS  Google Scholar 

  6. Wing KG. The experimental use of hypoglycemia to show whether glucose is a major fuel for the cochlear response, and further remarks concerning the lability of the vascular bed supplying the cochlear partition. Acta Otolaryngol. 1959;Suppl 148:87–93.

    Google Scholar 

  7. Mendelsohn M, Roderique J. Cationic changes in endolymph during hypoglycemia. Laryngoscope. 1972;82:1533–40.

    Article  CAS  Google Scholar 

  8. Thalmann R, Miyoshi T, Kusakari J, Ise I. Normal and abnormal energy metabolism of the inner ear. Otolaryngol Clin N Am. 1975;8:313–33.

    CAS  Google Scholar 

  9. Kuijpers W, Bonting SL. Localization and properties of ATPase in the inner ear of the guinea pig. Biochim Biophys Acta. 1969;173:477–85.

    Article  CAS  Google Scholar 

  10. Koide Y, Tajima S, Yoshida M, Konno M. Biochemical changes in the inner ear induced by insulin, in relation to cochlear microphonics. Ann Otol Rhinol Laryngol. 1960;69:1083–97.

    Article  CAS  Google Scholar 

  11. Suzuki T, Matsunami T, Hisa Y, Takata K, Takamatsu T, Oyamada M. Roles of gap junctions in glucose transport from glucose transporter 1-positive to -negative cells in the lateral wall of the rat cochlea. Histochem Cell Biol. 2009;131(1):89–102.

    Article  CAS  Google Scholar 

  12. Nin F, Hibino H, Doi K, Suzuki T, Hisa Y, Kurachi Y. The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear. Proc Natl Acad Sci U S A. 2008;105(5):1751–6.

    Article  CAS  Google Scholar 

  13. Quraishi IH, Raphael RM. Generation of the endocochlear potential: a biophysical model. Biophys J. 2008;94(8):L64–6.

    Article  CAS  Google Scholar 

  14. Jordão A. Estudos sobre a Diabete. Lisboa: Typographia da Academia; 1864.

    Google Scholar 

  15. Rust KR, Prazma J, Triana RJ, Michaelis OE 4th, Pillsbury HC. Inner ear damage secondary to diabetes mellitus. II. Changes in aging SHR/N-cp rats. Arch Otolaryngol Head Neck Surg. 1992;118(4):397–400.

    Article  CAS  Google Scholar 

  16. Harril JA. Headache and vertigo associated with hypoglycemia tendency. Laryngoscope. 1951;61:138–45.

    Google Scholar 

  17. Tintera JW, Goldman HB. Hypoadrenocorticism in otolaryngological surgical procedures. N Y St J Med. 1956;56:872–7.

    CAS  Google Scholar 

  18. Goldman HB. Hypoadrenocorticism and endocrinologic treatment of Meniere’s disease. N Y St J Med. 1962;62:377–82.

    CAS  Google Scholar 

  19. Powers WH. Metabolic aspects of Meniere’s disease. Laryngoscope. 1972;82:1176–85.

    Article  Google Scholar 

  20. Updegraff WR. Impaired carbohydrate metabolism and idiopathic Meniere’s disease. Ear Nose Throat J. 1977;56(4):160–3.

    CAS  PubMed  Google Scholar 

  21. Kraft JR. Detection of diabetes mellitus in situ (occult diabetes). Lab Med. 1976;6:10–22.

    Article  Google Scholar 

  22. Kraft JR. Diabetes epidemic and you: Trafford Publishing; 2008.

    Google Scholar 

  23. Fukuda Y. Glicemia, Insulinemia e Patologia da Orelha Interna. 1982, Ph.D. thesis. Escola Paulista de Medicina.

    Google Scholar 

  24. Mangabeira Albernaz PL, Fukuda Y. Glucose, insulin and inner ear pathology. Acta Otolaryngol (Stockh). 1984;97:496–501.

    Article  CAS  Google Scholar 

  25. Mangabeira-Albernaz PL, Fukuda Y, Vilela MP, Miszputen SJ. Vestibular disorders caused by defective enzyme mechanisms in the small intestine. Acta Otolaryngol (Stockh). 1985;99:330–5.

    Article  CAS  Google Scholar 

  26. Mangabeira-Albernaz PL, Miszputen SJ. Vertigem e enzimas digestivas. In: Zuma e Maia FC, Mangabeira Albernaz PL, Carmona PL, editors. Otoneurologia Atual. Rio de Janeiro: Revinter; 2014. p. 365–79.

    Google Scholar 

  27. Kazmierczak H, Doroszewska G. Metabolic disorders in vertigo, tinnitus, and hearing loss. Int Tinnitus J. 2001;7(1):54–8.

    CAS  PubMed  Google Scholar 

  28. Mangabeira-Albernaz PL. Inner ear disorders induced by impaired carbohydrate metabolism – a long term follow up. In: Lim DJ, editor. Meniere’s disease & inner ear homeostasis disorders – proceedings of the 5th international symposium. Los Angeles: House Ear Institute; 2005. p. 326–7.

    Google Scholar 

  29. D’Avila C, Lavinsky L. Glucose and insulin profiles and their correlations in Ménière’s disease. Int Tinnitus J. 2005;11:170–6.

    PubMed  Google Scholar 

  30. Zuma e Maia FC, Lavinsky L. Distortion product otoacoustic emissions in an animal model of induced hyperinsulinemia. Int Tinnitus J. 2006;12:133–9.

    PubMed  Google Scholar 

  31. Selcuk A, Terzi H, Turkay U, Kale A, Genc S. Does gestational diabetes result in cochlear damage? J Laryngol Otol. 2014;128:961–5.

    Article  CAS  Google Scholar 

  32. Mangabeira-Albernaz PL. Hearing loss, dizziness, and carbohydrate metabolism. Int Arch Otorhinolaryngol. 2016;20(3):261–70. https://doi.org/10.1055/s-0035-1558450.

    Article  Google Scholar 

  33. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Albernaz, P.L.M., Zuma e Maia, F., Carmona, S., Cal, R.V.R., Zalazar, G. (2019). Glucose, Insulin, and Inner Ear Pathology. In: The New Neurotology. Springer, Cham. https://doi.org/10.1007/978-3-030-11283-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-11283-7_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11282-0

  • Online ISBN: 978-3-030-11283-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics