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Animal Models in Retinoblastoma Research

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Clinical Ophthalmic Oncology

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Abstract

Many animal models of retinoblastoma exist, each of which recapitulates some, but not all, of the features of human disease. The most commonly used models that are available are described in this chapter. These include various genetic and xenograft models of retinoblastoma and include a multitude of species, such as mice, rats, rabbits, pigs, and nonhuman primates. A wide array of uses of animal models in retinoblastoma research are presented here, including those for the study of tumor biology and response to treatment, assessment of pharmacokinetics, and measurement of chemotherapeutic toxicity and efficacy for drug discovery. Importantly, we discuss the relative strengths and limitations of each model. Factors for investigators to consider in designing various types of experiments are highlighted, including type of tumor model (genetic or xenograft), immune status (native, immunologically naïve, genetically immunocompromised, or pharmacologically immunosuppressed), and choice of species. While a particular model may be ideal for a certain use, no single model is appropriate for all experiments. Species-specific factors are especially critical when studying regional and local chemotherapy delivery.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Nashville, TN, USA

    Thomas A. Mendel & Anthony B. Daniels

  2. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA

    Anthony B. Daniels

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  1. Thomas A. Mendel
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  2. Anthony B. Daniels
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Correspondence to Anthony B. Daniels .

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Editors and Affiliations

  1. Associate Professor of Ophthalmology, Children’s Hospital Los Angeles, The USC Roski Eye Institute Keck School of Medicine, Los Angeles, CA, USA

    Jesse L. Berry

  2. Children’s Hospital Los Angeles, The USC Roski Eye Institute, Keck School of Medicine, Los Angeles, CA, USA

    Jonathan W. Kim

  3. University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

    Bertil E. Damato

  4. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun D. Singh

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Mendel, T.A., Daniels, A.B. (2019). Animal Models in Retinoblastoma Research. In: Berry, J., Kim, J., Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-11123-6_7

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