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Retinoblastoma: Focal Therapies: Brachytherapy

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Clinical Ophthalmic Oncology

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Abstract

In the management of retinoblastoma, episcleral plaque brachytherapy is one of several modalities used to treat focal lesions either as primary therapy for smaller tumors (Group B) or in conjunction with intravenous chemotherapy after chemoreduction of larger focal lesions (Groups C–D). The technique is analogous to the one commonly performed for uveal melanoma. The recommended dose to the tumor apex is 45 Gy. Reported local control rates range between 79% and 94% at 5 years. Radiation retinopathy is the most common visually threatening complication, especially in those patients undergoing chemotherapy.

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Author information

Authors and Affiliations

  1. Departments of Vitreoretinal Surgery and Ocular Oncology, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA

    Jose J. Echegaray

  2. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun D. Singh

  3. University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

    Bertil E. Damato

Authors
  1. Jose J. Echegaray
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  2. Arun D. Singh
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  3. Bertil E. Damato
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Corresponding author

Correspondence to Arun D. Singh .

Editor information

Editors and Affiliations

  1. Associate Professor of Ophthalmology, Children’s Hospital Los Angeles, The USC Roski Eye Institute Keck School of Medicine, Los Angeles, CA, USA

    Jesse L. Berry

  2. Children’s Hospital Los Angeles, The USC Roski Eye Institute, Keck School of Medicine, Los Angeles, CA, USA

    Jonathan W. Kim

  3. University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

    Bertil E. Damato

  4. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun D. Singh

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Echegaray, J.J., Singh, A.D., Damato, B.E. (2019). Retinoblastoma: Focal Therapies: Brachytherapy. In: Berry, J., Kim, J., Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-11123-6_12

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  • DOI: https://doi.org/10.1007/978-3-030-11123-6_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11122-9

  • Online ISBN: 978-3-030-11123-6

  • eBook Packages: MedicineMedicine (R0)

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