Skip to main content

Chemotherapy for Pediatric Stem Cell Transplantation

  • Chapter
  • First Online:
Pediatric Oncologic Pharmacy

Abstract

Stem cell transplantation, which has been researched for a wide range of diseases, can be used in pediatric oncological area for bone marrow reconstitution with hematopoietic stem cells. There are two types of stem cell transplantation: autologous and allogeneic [109].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Muraro PA, Martin R, Mancardi GL, et al. Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis. Nat Rev Neurol. 2017;13:391–405.

    Article  CAS  Google Scholar 

  2. Buchbinder D, Danielpour M, Yong WH, Salamon N, Lasky J. Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue. J Neuro-Oncol. 2010;97(3):429–37.

    Article  Google Scholar 

  3. U.S. Department of Health and Human Services: National Cancer Institute. Childhood hematopoietic cell transplantation (PDQ®)–health professional version. https://www.cancer.gov/types/childhood-cancers/child-hct-hp-pdq. Accessed 20 Mar 2018.

  4. Hastings CA, Torkildson JC, Agrawal AK. Handbook of pediatric hematology and oncology: Children’s Hospital & Research Center Oakland. 2nd ed. New York: Wiley Blackwell; 2013.

    Google Scholar 

  5. St. Jude Children’s Research Hospital: Autologous stem cell/bone marrow transplant. https://www.stjude.org/disease/autologous-stem-cell-bone-marrow-transplant.html. Accessed 20 Mar 2018.

  6. Niewerth D, Creutzig U, Bierings MB, Kaspers GJL. A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia. Blood. 2010;116:2205–14.

    Article  CAS  Google Scholar 

  7. Science M, Robinson PD, MacDonald T, et al. Guideline for primary antifulgal prophylaxis for pediatric patients with cancer or hematopoietic stem cell transplant recipients. Pediatr Blood Cancer. 2014;61(3):393–400.

    Article  Google Scholar 

  8. Yoshikawa K, Nakazawa Y, Katsuyama Y, et al. Safety, tolerability, and feasibility of antifungal prophylaxis with micafungin at 2 mg/kg daily in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation. Infection. 2014;42(4):639–47.

    Article  CAS  Google Scholar 

  9. Pieters R, Schrappe M, Valsecchi MG, Biondi A, et al. INTERFANT-06: International collaborative treatment protocol for infants under one year with acute lymphoblastic or biphenotypic leukemia. Stichting Kinderoncologie Nederland. 2016. https://www.skion.nl/workspace/uploads/Interfant-06_version16b_1aug2016_stop-Rand_MEC.pdf. Accessed 13 Jan 2017.

  10. Döring M, Blume O, Haufe S, et al. Comparison of itraconazole, voriconazole, and posaconazole as oral antifungal prophylaxis in pediatric patients following allogeneic hematopoietic stem cell transplantation. Eur J Clin Microbiol Infect Dis. 2014;33:629.

    Article  Google Scholar 

  11. Cecinati V, Principi N, Brescia L, Esposito S. Antibiotic prophylaxis in children with cancer or who have undergone hematopoietic cell transplantation. Eur J Clin Microbiol Infect Dis. 2014;33(1):1–6.

    Article  CAS  Google Scholar 

  12. Hafez HA, Yousef D, Abbassi M, Elborai Y, Elhaddad A. Prophylactic levofloxacin in pediatric neutropenic patients during autologous hematopoietic stem cell transplantation (HSCT). Blood. 2013;122:5462.

    Google Scholar 

  13. Schechter T, Gassas A, Klein J, et al. Antibiotic prophylaxis therapy for pediatric patients undergoing hematopoietic stem cell transplant (HSCT): a tale of two centers. Biol Blood Marrow Transplant. 2014. https://www.bbmt.org/article/S1083-8791(13)00907-5/pdf.

  14. Fischer BT, Alexander S, Dvorak CC, et al. Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. Pediatr Blood Cancer. 2012;59:11–5.

    Article  Google Scholar 

  15. Flinn AM, Gennery AR. Tratment of pediatric acute graft-versus-host disease—Lessons from primary immunodeficiency? Front Immunol. 2017;8:328.

    Article  Google Scholar 

  16. Jacobsohn DA, Volgelsang GB. Acute graft versus host disease. Orphanet J Rare Dis. 2007;2:35.

    Article  Google Scholar 

  17. Jacobsohn DA, Gilman AL, Rademaker A, et al. Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a pediatric blood and marrow transplant consortium study. Blood. 2009;114:4354–60.

    Article  CAS  Google Scholar 

  18. Schmidt CWP. Chemotherapy in neonates and infants: pharmacological oncology for children under 1 year old. Switzerland: Springer; 2018.

    Book  Google Scholar 

  19. Leclerc V, Ducher M, Bleyzac N. Bayesian networks: a new approach to predict therapeutic range achievement of initial cyclosporine blood concentration after pediatric hematopoietic stem cell transplantation. Drugs R D. 2018;18(1):67–75.

    Article  CAS  Google Scholar 

  20. Carpenter PA, MacMillan ML. Management of acute graft versus host disease in children. Pediatr Clin N Am. 2011;57(1):273–95.

    Article  Google Scholar 

  21. Harris AC, Young R, Devine S, et al. International, multi-center standardization of acute graft-versus-host disease clinical data collection: a report from the MAGIC consortium. Biol Blood Marrow Transplant. 2016;22(1):4–10.

    Article  Google Scholar 

  22. Taketomo C, Hodding J, Kraus D. Pediatric & neonatal dosage handbook. 21st ed. United States of America: Lexicomp; 2014.

    Google Scholar 

  23. Inagaki J, Kodama Y, Fukano R, Noguchi M, Okamura J. Mycophenolate mofetil for treatment of steroid-refractory acute graft-versus-host disease after pediatric hematopoietic stem cell transplantation. Pediatr Transplant. 2015;19(6):652–8.

    Article  CAS  Google Scholar 

  24. Barrett D, Fish JD, Grupp SA. Autologous and allogeneic cellular therapies for high-risk pediatric solid tumors. Pediatr Clin N Am. 2010;57(1):47–66.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Schmidt, C.W.P. (2019). Chemotherapy for Pediatric Stem Cell Transplantation. In: Pediatric Oncologic Pharmacy. Springer, Cham. https://doi.org/10.1007/978-3-030-10988-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-10988-2_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-10987-5

  • Online ISBN: 978-3-030-10988-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics