Cornea Transplantation

  • Jonathan Fay
  • George J. Florakis


The cornea is the transparent tissue at the front of the eye that covers the anterior chamber, iris, and pupil. It serves as a barrier to the outside world and is an important refractive component in the optical system of the eye. Without a clear, healthy cornea, good vision is not possible. The cornea is composed of five layers: epithelium, Bowman’s layer, stroma, Descemet’s membrane, and endothelium. At the surface lies the epithelium, a regenerative stratified squamous epithelium that plays an important role in host defense against pathogens. Next, Bowman’s layer is a thin layer of condensed collagen located between the epithelial basement membrane and corneal stroma. The stroma is the thick middle layer of the cornea consisting of regularly arranged collagen fibers and sparsely distributed cells.


Cornea transplantation Transplantation of the cornea Keratoplasty Surgery of the cornea Penetrating keratoplasty Deep anterior lamellar keratoplasty Descemet’s stripping (automated) endothelial keratoplasty Descemet’s membrane endothelial keratoplasty 

Suggested Reading

  1. Crawford AZ, Patel DV, McGhee CN. A brief history of corneal transplantation: from ancient to modern. Oman J Ophthalmol. 2013;6(Suppl 1):S12–7. Scholar
  2. Eye Bank of Association of America.
  3. Park CY, Lee JK, Gore PK, Lim CY, Chuck RS. Keratoplasty in the United States: a 10-year review from 2005 through 2014. Ophthalmology. 2015;122:2432–42. Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jonathan Fay
    • 1
  • George J. Florakis
    • 2
  1. 1.Klamath Eye CenterKlamath FallsUSA
  2. 2.Department of Ophthalmology, Edward S. Harkness Eye InstituteColumbia University Vagelos College of Physicians and SurgeonsNew YorkUSA

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