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Innate Immunity: Phagocytes, Natural Killer Cells, and the Complement System

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Book cover Nijkamp and Parnham's Principles of Immunopharmacology

Abstract

In the second half of the nineteenth century, Eli Metchnikoff discovered that bacteria can be ingested (phagocytosed) by LEUKOCYTES present in the blood of a variety of animals. At about the same time, Paul Ehrlich found that certain agents dissolved in blood had bactericidal potential. The scientific discussion on the importance of cellular versus humoral factors in our defense against bacteria that followed came to an end when it was recognized that both components enforce each other’s effect within the context of the IMMUNE SYSTEM. In 1908, both scientists shared the Nobel Prize for Physiology and Medicine. Further investigations on the nature and the working mechanism of the cells and the proteins that constitute our immunological defense system showed that each of these components is made up of several different constituents. In its turn, this led to the view that a functional distinction exists between the adaptive and the innate branch of the IMMUNE SYSTEM.

Final manuscript submitted on May 3, 2017.

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Acknowledgments

This chapter is a partial update of versions in previous editions of this book, originally created by D. Roos and C.E. Hack and subsequently modified by T.K. van den Berg and D. Wouters.

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Authors and Affiliations

  1. Translational Drug Validation, Fraunhofer IME-TMP and Goethe University Frankfurt, Frankfurt am Main, Germany

    Michael J. Parnham

  2. Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK

    Adriano G. Rossi

Authors
  1. Michael J. Parnham
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  2. Adriano G. Rossi
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Corresponding author

Correspondence to Michael J. Parnham .

Editor information

Editors and Affiliations

  1. Translational Drug Validation, Fraunhofer IME-TMP and Goethe University Frankfurt, Frankfurt am Main, Germany

    Michael J. Parnham

  2. Utrecht University, Utrecht, The Netherlands

    Frans P. Nijkamp

  3. The Queen’s Medical Research Institute, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK

    Adriano G. Rossi

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Parnham, M.J., Rossi, A.G. (2019). Innate Immunity: Phagocytes, Natural Killer Cells, and the Complement System. In: Parnham, M., Nijkamp, F., Rossi, A. (eds) Nijkamp and Parnham's Principles of Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-10811-3_8

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