Skip to main content

Seminal VOCs Analysis Investigating Sperm Quality Decline—New Studies to Improve Male Fertility Contrasting Population Ageing

  • Conference paper
  • First Online:
Ambient Assisted Living (ForItAAL 2018)


The world is impacting with a drastic demographic change that is reflected in a progressive ageing population. If on the one side increasing health care for older people is important, stimulating the level of birth becomes decisive. The principal goal of this work is to set up of new method for early diagnosis of male infertility based on analysis of seminal Volatile Organic Compounds (VOCs), potentially biomarkers of infertility status. The identification of the volatile metabolite patterns in semen samples was done by an unconventional GC/[−MS + gas sensor] system. Once validate this approach could integrate and improve traditional semen analysis based on physiological parameters and addressed to the development of novel medical devices based on gas microsensors for male infertility screening.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others


  1. Callen T, McKibbin JW, Batini N (2006) The global impact of demographic change. IMF Working Paper, pp 1–36

    Article  Google Scholar 

  2. Inhorn MC, Patrizio P (2015) Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update 21(4):411–426

    Article  Google Scholar 

  3. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, Krausz C (2012) European association of urology working group on male infertility. European association of urology guidelines on male infertility: the 2012 update. Eur Urol 62(2):324–332.

    Article  Google Scholar 

  4. Lunenfeld B, Van Steirteghem A (2004) Infertility in the third millennium: implications for the individual, family and society: Condensed Meeting Report from the Bertarelli Foundation’s second global conference. Human Reprod Update 10(4):317–326.

    Article  Google Scholar 

  5. Pettinger T. The impact of an ageing population on the economy.

  6. UN/DESA Department of economic and social affairs population division: world population ageing (2015)

    Google Scholar 

  7. Vas G, Vékey K (2004) Solid-phase microextraction: a powerful sample preparation tool prior to mass spectrometric analysis. J Mass Spectrom 39(3):233–254

    Article  Google Scholar 

  8. World Health Organisation (2010) WHO laboratory manual for the examination and processing of human seme, 5th edn. WHO, Geneva, Switzerland

    Google Scholar 

  9. Zhang X, Diao R, Zhu X, Li Z, Cai Z (2015) Metabolic characterization of asthenozoospermia using nontargeted seminal plasma metabolomics. Clin Chim Acta 450:254–261.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Valentina Longo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Longo, V. et al. (2019). Seminal VOCs Analysis Investigating Sperm Quality Decline—New Studies to Improve Male Fertility Contrasting Population Ageing. In: Leone, A., Caroppo, A., Rescio, G., Diraco, G., Siciliano, P. (eds) Ambient Assisted Living. ForItAAL 2018. Lecture Notes in Electrical Engineering, vol 544. Springer, Cham.

Download citation

  • DOI:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-05920-0

  • Online ISBN: 978-3-030-05921-7

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics