Skip to main content

Development of Biocomposite Materials from Biodegradable Polymer and Bio-hydroxyapatite Derived from Eggshells for Biomedical Applications

  • Conference paper
  • First Online:
Characterization of Minerals, Metals, and Materials 2019

Abstract

Nowadays, significant advances have been made in the development of biodegradable polymeric materials for biomedical applications . This study aims to prepare and characterize composite materials based on PLA/PBAT, a biodegradable polymer blend , reinforced with bio-hydroxyapatite (bio-HAp). First, bio-HAp was obtained from eggshell residues by the wet precipitation method. PLA/PBAT blend with 1.5 wt% of bio-HAp was prepared by melt extrusion and injection molding process. Part of composite samples was irradiated with gamma radiation dose of 25 kGy, at room temperature and presence of air. The effects of the bio-HAp addition into the biodegradable blend were investigated by mechanical tests, XRD , DSC , FE-SEM , and cytotoxicity “in vitro” analysis and the correlation between the properties was discussed. In addition, the microbiological tests were carried out at irradiated and non-irradiated composite samples in order to evaluate the efficiency of the radiation dose of 25 kGy at composite materials sterilization.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Marques RD (2011) Obtaining and characterizing polymer blends of poly (lactic-co-glycolic acid) and poly (isoprene) for application as biomaterial. J Polymer Environ 234–241

    Google Scholar 

  2. Muthuraj R, Misra M, Mohanty AK (2014) Biodegradable poly (butylene succinate) and poly (butylene adipate-co-terephthalate) blends: reactive extrusion and performance evaluation. J Polymer Environ 336–349

    Article  CAS  Google Scholar 

  3. Kang Y, Chen P, Shi X, Zhang G, Wang C (2018) Preparation of open-porous stereocomplex PLA/PBAT scaffolds and correlation between their morphology, mechanical behavior, and cell compatibility. R Soc Chem 65–75

    Google Scholar 

  4. Moraes MFV (2004) Produção e caracterização de blenda polimérica biodegradável poli(hidroxibutirato)[PHB]/copoliéster alifático aromático para aplicações em embalagens

    Google Scholar 

  5. Adrar S, Habi A, Ajji A, Grohens Y (2018) Synergistic effects in epoxy functionalized graphene and modified organo-montmorillonite PLA/PBAT blends. Appl Clay Sci 12933–12943

    Google Scholar 

  6. Kijchavengkul T, Auras R, Rubino M, Selke S, Ngouajio M, Fernandez T (2010) Biodegradation and hydrolysis rate of aliphatic aromatic polyester. Polymer Degrad Stab 2641–2647

    Article  CAS  Google Scholar 

  7. Caliman LB (2011) Síntese e caracterização de hidroxiapatita obtida a partir de casca de ovo de avestruz. Química nova 142–150

    Google Scholar 

  8. Ferreira SW, Costa RMC, Ferreira BRS, Nunes FS (2017) Structural and electronic properties of hydroxyapatite from calculations of first principles. Engevista 194–201

    Article  Google Scholar 

  9. Charlesby A (1960) Atomic Radiation and polymers. Pergamon Press, New York

    Google Scholar 

  10. Abbona F (1996) A XRD and TEM study on the transformation of amorphous calcium phosphate in the presence of magnesium. J Cryst Growth 165:98–105

    Article  CAS  Google Scholar 

  11. Al-Itry R, Lamnawar K, Maazouz A (2014) Reactive extrusion of PLA, PBAT with a multi-functional epoxide: physico-chemical and rheological properties. Eur Polymer J 58:90–102

    Article  CAS  Google Scholar 

  12. Arruda CL, Magaton M, Bretas RES, Ueki MM (2016) Influence of chain extender on mechanical, thermal and morphological properties of blown films of PLA/PBAT blends. Polym Test 43:27–37

    Article  Google Scholar 

  13. Kang Y, Chen P, Shi X, Zhang G, Wang C (2018) Preparation of open-porous stereocomplex PLA/PBAT scaffolds and correlation between their morphology, mechanical behavior, and cell compatibility. R Soc Chem 8:65–75

    Google Scholar 

Download references

Acknowledgements

The authors wish to thank CAPES and IPEN for providing the support for this work.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pedro R. S. Reis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 The Minerals, Metals & Materials Society

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Reis, P.R.S., Santana, J.G., Oliveira, R.R., Rangari, V.K., Lourenço, F.R., Moura, E.A.B. (2019). Development of Biocomposite Materials from Biodegradable Polymer and Bio-hydroxyapatite Derived from Eggshells for Biomedical Applications. In: Li, B., et al. Characterization of Minerals, Metals, and Materials 2019. The Minerals, Metals & Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-030-05749-7_57

Download citation

Publish with us

Policies and ethics